Gene Symbol: hsp90aa1.1
Description: heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
Alias: fb17b01, hsp90, hsp90a, hsp90a.1, hsp90alpha, wu:fb17b01, zgc:86652, heat shock protein HSP 90-alpha 1, akineto, heat shock protein 90-alpha 1, slo, sloth
Species: zebrafish
Products:     hsp90aa1.1

Top Publications

  1. Lele Z, Hartson S, Martin C, Whitesell L, Matts R, Krone P. Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90. Dev Biol. 1999;210:56-70 pubmed
    ..However, early development of adaxial cells, which give rise to muscle pioneers and which strongly express the hsp90alpha gene shortly before muscle pioneer formation, appeared unaffected...
  2. Etard C, Behra M, Fischer N, Hutcheson D, Geisler R, Strahle U. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Dev Biol. 2007;308:133-43 pubmed
    ..We show that Steif/Unc-45b interacts with the chaperone Hsp90a in vitro...
  3. Codina M, Li J, Gutierrez J, Kao J, Du S. Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos. PLoS ONE. 2010;5:e8416 pubmed publisher
  4. Just S, Meder B, Berger I, Etard C, Trano N, Patzel E, et al. The myosin-interacting protein SMYD1 is essential for sarcomere organization. J Cell Sci. 2011;124:3127-36 pubmed publisher
    ..By contrast, ectopic expression of myosin-binding-deficient SMYD1 does not rescue fla mutants, implicating an essential role for the SMYD1-myosin interaction in cardiac and fast-twitch skeletal muscle thick filament assembly...
  5. Du S, Li H, Bian Y, Zhong Y. Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proc Natl Acad Sci U S A. 2008;105:554-9 pubmed publisher
    Heat-shock protein 90alpha (Hsp90alpha) is a member of the molecular chaperone family involved in protein folding and assembly. The role of Hsp90alpha in the developmental process, however, remains unclear...
  6. Yeyati P, Bancewicz R, Maule J, van Heyningen V. Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet. 2007;3:e43 pubmed
    Compromised heat shock protein 90 (Hsp90) function reveals cryptic phenotypes in flies and plants...
  7. Sass J, Martin C, Krone P. Restricted expression of the zebrafish hsp90alpha gene in slow and fast muscle fiber lineages. Int J Dev Biol. 1999;43:835-8 pubmed
    ..We have previously shown that hsp90alpha gene expression in early zebrafish embryos is restricted to a subgroup of paraxial-mesoderm derived somitic ..
  8. Bernick E, Zhang P, Du S. Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos. BMC Cell Biol. 2010;11:70 pubmed publisher
    Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C...
  9. Etard C, Roostalu U, Strahle U. Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril. J Cell Biol. 2008;180:1163-75 pubmed publisher
    The formation of thick filaments in striated muscle involves the chaperones Hsp90a and Unc45...

More Information


  1. Hawkins T, Haramis A, Etard C, Prodromou C, Vaughan C, Ashworth R, et al. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 2008;135:1147-56 pubmed publisher
    ..Surprisingly, we find that the phenotype is due to mutation in one copy of a tandemly duplicated hsp90a gene. The mutation disrupts the chaperoning function of Hsp90a through interference with ATPase activity...
  2. Sass J, Weinberg E, Krone P. Specific localization of zebrafish hsp90 alpha mRNA to myoD-expressing cells suggests a role for hsp90 alpha during normal muscle development. Mech Dev. 1996;54:195-204 pubmed
    Members of the eukaryotic hsp90 family function as important molecular chaperones in the assembly, folding and activation of a select group of cellular signalling molecules and transcription factors...
  3. Myhre J, Hills J, Prill K, Wohlgemuth S, Pilgrim D. The titin A-band rod domain is dispensable for initial thick filament assembly in zebrafish. Dev Biol. 2014;387:93-108 pubmed publisher
    ..These findings are also consistent with the symptoms of human titin myopathies that exhibit a late onset, such as tibial muscular dystrophy. ..
  4. Sissener N, Johannessen L, Hevrøy E, Wiik Nielsen C, Berdal K, Nordgreen A, et al. Zebrafish ( Danio rerio) as a model for investigating the safety of GM feed ingredients (soya and maize); performance, stress response and uptake of dietary DNA sequences. Br J Nutr. 2010;103:3-15 pubmed publisher
    ..In conclusion, zebrafish shows promise as a model for this application. ..
  5. Robles V, Marti M, Izpisua Belmonte J. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. Zebrafish. 2011;8:57-63 pubmed publisher
    ..We consider this study a step forward in the knowledge of zebrafish pluripotency markers and, therefore, an important tool for the monitoring of zebrafish embryonic cell cultures. ..
  6. Bruns A, Yuldasheva N, Latham A, Bao L, Pellet Many C, Frankel P, et al. A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE. 2012;7:e48539 pubmed publisher
    ..Pharmacological inhibition of HSP90 stimulated VEGFR2 degradation in primary endothelial cells and blocked VEGF-A-stimulated intracellular signaling ..
  7. Redelstein R, Zielke H, Spira D, Feiler U, Erdinger L, Zimmer H, et al. Bioaccumulation and molecular effects of sediment-bound metals in zebrafish embryos. Environ Sci Pollut Res Int. 2015;22:16290-304 pubmed publisher
    ..MT1 and MT2, the metal-responsive element-binding transcription factor (MTF) and the genes sod1, hsp70 and hsp90α1 were measured as indicators of metal-induced or general cellular stress. D...
  8. Bishop O, Edkins A, Blatch G. Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function. J Exp Zool B Mol Dev Evol. 2014;322:359-78 pubmed publisher
    ..Heat shock protein 90 (Hsp90) and heat shock protein 40 (Hsp40) chaperones, and associated co-chaperones were focused on, and homologous human ..
  9. Hinits Y, Osborn D, Hughes S. Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations. Development. 2009;136:403-14 pubmed publisher
    ..Mrf4 does not contribute to early myogenesis in zebrafish. We suggest that the differential use of duplicated MRF paralogues in this novel two-component myogenic system facilitated the diversification of vertebrates...
  10. Christen B, Robles V, Raya M, Paramonov I, Izpisua Belmonte J. Regeneration and reprogramming compared. BMC Biol. 2010;8:5 pubmed publisher
    ..We therefore propose a link between partially reprogrammed induced pluripotent stem cells and the half way state of blastema cells and suggest that a common mechanism might be regulating these two processes. ..
  11. Ko S, Jin H, Jung D, Tian X, Shin I. Cardiosulfa, a small molecule that induces abnormal heart development in zebrafish, and its biological implications. Angew Chem Int Ed Engl. 2009;48:7809-12 pubmed publisher
  12. Etard C, Roostalu U, Strahle U. Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos. J Cell Biol. 2010;189:527-39 pubmed publisher
    The chaperones Unc45b and Hsp90a are essential for folding of myosin in organisms ranging from worms to humans...
  13. Baxendale S, Chen C, Tang H, Davison C, Hateren L, Croning M, et al. Expression screening and annotation of a zebrafish myoblast cDNA library. Gene Expr Patterns. 2009;9:73-82 pubmed publisher
  14. Jerônimo R, Moraes M, de Assis L, Ramos B, Rocha T, Castrucci A. Thermal stress in Danio rerio: a link between temperature, light, thermo-TRP channels, and clock genes. J Therm Biol. 2017;68:128-138 pubmed publisher
    ..After heat shock, we observed an acute increase of hsp90 aa1 levels in both DD and LD conditions...
  15. Taherian A, Krone P, Ovsenek N. A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates. Biochem Cell Biol. 2008;86:37-45 pubmed publisher
    ..The substrates Raf-1, HSF1, Cdc37, and MEK1 interacted with both Hsp90alpha and Hsp90beta, and the relative patterns of these interactions were not affected by heat shock...
  16. Osborn D, Li K, Hinits Y, Hughes S. Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol. 2011;350:464-75 pubmed publisher
    ..Cdkn1c co-operates with Myod to drive differentiation of several early zebrafish muscle fibre types. Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation. ..
  17. Xu H, Liu E, Li Y, Li X, Ding C. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Int J Mol Sci. 2017;18: pubmed publisher
    ..The findings of this study are important for understanding the physiological switches during the mouth-opening stage. ..
  18. Connolly M, Hall B. Embryonic heat shock reveals latent hsp90 translation in zebrafish (Danio rerio). Int J Dev Biol. 2008;52:71-9 pubmed
    ..is explored in the context of environmental stress by investigating the activity of heat shock protein-90 (HSP90), a cytosolic chaperone that interacts with transcription factors to mediate multiple developmental pathways...
  19. Comyn S, Pilgrim D. Lack of developmental redundancy between Unc45 proteins in zebrafish muscle development. PLoS ONE. 2012;7:e48861 pubmed publisher
    ..Instead, our phylogenetic and phenotypic analyses provide evidence for the role of functional divergence in the evolution of the UCS protein family. ..
  20. Li H, Zhong Y, Wang Z, Gao J, Xu J, Chu W, et al. Smyd1b is required for skeletal and cardiac muscle function in zebrafish. Mol Biol Cell. 2013;24:3511-21 pubmed publisher
    ..quantitative reverse transcription-PCR analyses show that knockdown of smyd1b up-regulates heat shock protein 90 (hsp90) and unc45b gene expression...
  21. Hinits Y, Hughes S. Mef2s are required for thick filament formation in nascent muscle fibres. Development. 2007;134:2511-9 pubmed
    ..Our findings show that Mef2 controls skeletal muscle formation after terminal differentiation and define a new maturation step in vertebrate skeletal muscle development at which thick filament gene expression is controlled. ..
  22. Zhang C, Zhang J, Ren H, Zhou B, Wu Q, Sun P. Effect of tributyltin on antioxidant ability and immune responses of zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2017;138:1-8 pubmed publisher
    ..05). However, the expression of the HSP70, HSP90, tumor necrosis factor-?(TNF-?), interleukins (IL-1?, IL-6), and nuclear factor-kappa B p65 (NF-? B p65) genes ..
  23. He Q, Liu K, Tian Z, Du S. The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization. PLoS ONE. 2015;10:e0142573 pubmed publisher
    ..To assess the structure and function of Hsp90α and its potential regulation by post-translational modification, we developed a combined knockdown and rescue ..
  24. Keller E, Murtha J. The use of mature zebrafish (Danio rerio) as a model for human aging and disease. Comp Biochem Physiol C Toxicol Pharmacol. 2004;138:335-41 pubmed
    ..These highlights demonstrate the utility of zebrafish as a model for disease and aging. ..
  25. Pei W, Feldman B. Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Dev Biol. 2009;326:201-11 pubmed publisher
    ..There is a concordance of MB with cyclopia in MZsqt embryos. Heat treatment and depletion of Hsp90a are "common" risk factors, each of which increases the incidence of both phenotypes...
  26. Dorts J, Falisse E, Schoofs E, Flamion E, Kestemont P, Silvestre F. DNA methyltransferases and stress-related genes expression in zebrafish larvae after exposure to heat and copper during reprogramming of DNA methylation. Sci Rep. 2016;6:34254 pubmed publisher
    ..These results highlighted the sensitivity of early embryogenesis and more precisely of the reprogramming period to environmental challenges, in a realistic situation of combined stressors. ..
  27. Ye B, Deng X, Shao L, Lu Y, Xiao R, Liu Y, et al. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2015;194:4489-97 pubmed publisher
    ..At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration...
  28. Wang Y, Qian L, Dong Y, Jiang Q, Gui Y, Zhong T, et al. Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development. Mech Dev. 2006;123:783-91 pubmed
    ..Microarray studies reveal a number of genes that are differentially expressed in the MEF2A morphants. Our studies suggest that MEF2A is essential for zebrafish posterior somite development. ..
  29. Sheehan Rooney K, Swartz M, Zhao F, Liu D, Eberhart J. Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR). Dis Model Mech. 2013;6:1285-91 pubmed publisher
    ..We demonstrate that, unexpectedly, the chaperone proteins Ahsa1 and Hsp90 promote severe craniofacial phenotypes in our zebrafish model of HDR syndrome...
  30. Geronikolou S, Pavlopoulou A, Kanaka Gantenbein C, Chrousos G. Inter-species functional interactome of nuclear steroid receptors (R1). Front Biosci (Elite Ed). 2018;10:208-228 pubmed
  31. Kuo Z, Chuang Y, Chao C, Liu F, Lan C, Chen B. Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. J Innate Immun. 2013;5:137-52 pubmed publisher
    ..albicans and the immune response of the host, and may help improve medical therapies and facilitate the development of new antifungal drugs...
  32. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  33. Craig P, Hogstrand C, Wood C, McClelland G. Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio. Physiol Genomics. 2009;40:23-33 pubmed publisher
    ..5% contained only a consensus MRE. We conclude that the indirect effects of Cu exposure regulate gene expression to a much greater degree than the direct effects. ..
  34. Malek R, Sajadi H, Abraham J, Grundy M, Gerhard G. The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2004;138:363-73 pubmed
    ..Additional studies will be required to further delineate the role of altered gene expression and oxidative stress on the longevity-promoting effects of temperature reduction. ..
  35. Etard C, Armant O, Roostalu U, Gourain V, Ferg M, Strähle U. Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome Biol. 2015;16:267 pubmed publisher
    ..Taken together, our data show that skeletal muscle cells respond to defective myosin chaperones with a complex gene program and suggest that this response is mediated by Hsf1 activation. ..
  36. Yang L, Kemadjou J, Zinsmeister C, Bauer M, Legradi J, Muller F, et al. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol. 2007;8:R227 pubmed
    ..Our work provides proof-of-principle for the use of the zebrafish embryo as a toxicogenomic model and highlights its potential for systematic, large-scale analysis of the effects of chemicals on the developing vertebrate embryo. ..
  37. Prill K, Windsor Reid P, Wohlgemuth S, Pilgrim D. Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly. PLoS ONE. 2015;10:e0142528 pubmed publisher