Gene Symbol: hsd17b2
Description: hydroxysteroid (17-beta) dehydrogenase 2
Alias: estradiol 17-beta-dehydrogenase 2
Baker M. Evolutionary analysis of 11beta-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17beta-hydroxysteroid dehydrogenase-type 2 in fish. FEBS Lett. 2004;574:167-70 pubmed
..Also unexpectedly, searches with 11beta-HSD1 only identified several fish 11beta-HSD3s, as well as an ortholog in Ciona, indicating that 11beta-HSD3 is the ancestor of 11beta-HSD1. ..
Mindnich R, Hrabe de Angelis M, Adamski J. Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. J Steroid Biochem Mol Biol. 2007;103:35-43 pubmed
..The closely related 11beta-HSD 2 is unlikely to substitute for 17beta-HSD 2 since in our hands it did not catalyze the respective oxidation of testosterone or estradiol. ..
Filby A, Paull G, Searle F, Ortiz Zarragoitia M, Tyler C. Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol. 2012;46:3472-9 pubmed publisher
..The extensive molecular, genetic, physiological, and behavioral toolbox now available for the zebrafish makes this species an attractive model for integrated analyses of chemical effects spanning behavior to molecular effect mechanisms. ..
Yu R, Chu D, Tan T, Li V, Chan A, Giesy J, et al
. Leptin-mediated modulation of steroidogenic gene expression in hypoxic zebrafish embryos: implications for the disruption of sex steroids. Environ Sci Technol. 2012;46:9112-9 pubmed publisher
..Overall, this study indicates that hypoxia, possibly via HIF-1-induced leptin expression, modulates sex steroid synthesis by acting directly on steroidogenic gene expression. ..
Liang Y, Huang G, Lin Z, Li J, Yang J, Zhong L, et al
. Reproductive effects of synthetic progestin norgestrel in zebrafish (Danio rerio). Chemosphere. 2018;190:17-24 pubmed publisher
Tan T, Yu R, Wu R, Kong R. Overexpression and Knockdown of Hypoxia-Inducible Factor 1 Disrupt the Expression of Steroidogenic Enzyme Genes and Early Embryonic Development in Zebrafish. Gene Regul Syst Bio. 2017;11:1177625017713193 pubmed publisher
..Overall, the findings from this study indicate that HIF-1-mediated mechanisms are likely involved in the regulation of specific steroidogenic genes. ..