hpx

Summary

Gene Symbol: hpx
Description: hemopexin
Alias: wu:fi17f11, wu:fi19a10, hemopexin
Species: zebrafish

Top Publications

  1. Passeri M, Cinaroglu A, Gao C, Sadler K. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009;49:443-52 pubmed publisher
    ..Srebp activation is required for steatosis in this model. The tractability of zebrafish genetics provides a valuable tool for dissecting the molecular pathogenesis of acute ALD. ..
  2. Andreeva A, Lamas N, Serebryakova M, Ryabtseva I, Bolshakov V. Reorganization of low-molecular-weight fraction of plasma proteins in the annual cycle of cyprinidae. Biochemistry (Mosc). 2015;80:208-18 pubmed publisher
    ..MALDI mass-spectrometry analysis revealed the presence of the same proteins (hemopexin, apolipoproteins, and serpins) in the low-molecular-weight plasma fraction in wild species and cultured species ..
  3. Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, et al. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol. 2010;10:21 pubmed publisher
    ..The DIO zebrafish can be used to identify putative pharmacological targets and to test novel drugs for the treatment of human obesity. ..
  4. Peterson S, Zhang J, Weber G, Freeman J. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Environ Health Perspect. 2011;119:615-21 pubmed publisher
    ..Moreover, we identified a number of novel targets for future exploration into their role in the genetic mechanisms underlying Pb-induced neurological alterations. ..
  5. Huang T, Chen J. Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1. Fish Shellfish Immunol. 2013;34:593-8 pubmed publisher
    ..Our findings imply that epinecidin-1 may stabilize the cytoskeleton network in host cells, thereby promoting resistance to bacterial infection. ..
  6. Babaei F, Ramalingam R, Tavendale A, Liang Y, Yan L, Ajuh P, et al. Novel blood collection method allows plasma proteome analysis from single zebrafish. J Proteome Res. 2013;12:1580-90 pubmed publisher
    ..Twenty-seven gender-dependent plasma proteins are identified and their biochemical importance discussed. Taken together, this novel technique enables analyses that were previously difficult to perform on zebrafish blood. ..
  7. Howarth D, Yin C, Yeh K, Sadler K. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish. 2013;10:199-210 pubmed publisher
    ..This study provides a panel of parameters to assess liver disease that can be easily applied to zebrafish mutants, transgenics, and for drug screening in which liver function is an important consideration. ..
  8. O Shields B, McArthur A, Holowiecki A, Kämper M, Tapley J, Jenny M. Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. Biochim Biophys Acta. 2014;1843:1818-33 pubmed publisher
    ..Finally, we investigate both the transcriptional activator and transcriptional repressor role of MTF-1 in potential novel target genes identified by transcriptomic profiling during early zebrafish development. ..
  9. Holowiecki A, O Shields B, Jenny M. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicol Appl Pharmacol. 2016;311:74-87 pubmed publisher
    ..These results demonstrate distinct mechanisms of hmox and bvr transcriptional regulation in zebrafish, providing initial evidence of the partitioning of function of the hmox paralogs. ..

More Information

Publications10

  1. Vettori A, Greenald D, Wilson G, Peron M, Facchinello N, Markham E, et al. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1? stabilization. Proc Natl Acad Sci U S A. 2017;114:9948-9953 pubmed publisher
    ..Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL. ..