hoxd13a

Summary

Gene Symbol: hoxd13a
Description: homeobox D13a
Alias: hoxd-13, hoxd13, zgc:110511, homeobox protein Hox-D13, homeo box D13a, homeobox gene D-13
Species: zebrafish

Top Publications

  1. Sakamoto K, Onimaru K, Munakata K, Suda N, Tamura M, Ochi H, et al. Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development. PLoS ONE. 2009;4:e5121 pubmed publisher
    ..Scyliorhinus canicula), however, we found that Shh was transcribed late in fin development, concomitant with Hoxd13 expression...
  2. Freitas R, Gómez Marín C, Wilson J, Casares F, Gomez Skarmeta J. Hoxd13 contribution to the evolution of vertebrate appendages. Dev Cell. 2012;23:1219-29 pubmed publisher
    ..Here, we overexpress hoxd13a in zebrafish to investigate the impact of increasing 5'Hoxd expression during fin development...
  3. Pyati U, Cooper M, Davidson A, Nechiporuk A, Kimelman D. Sustained Bmp signaling is essential for cloaca development in zebrafish. Development. 2006;133:2275-84 pubmed
    ..Furthermore, our data suggest that alterations in Bmp signaling are one possible cause of anorectal malformations during human embryogenesis...
  4. Zhang J, Wagh P, Guay D, Sanchez Pulido L, Padhi B, Korzh V, et al. Loss of fish actinotrichia proteins and the fin-to-limb transition. Nature. 2010;466:234-7 pubmed publisher
    ..We propose that the loss of both actinodins and actinotrichia during evolution may have led to the loss of lepidotrichia and may have contributed to the fin-to-limb transition...
  5. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..
  6. Mehta T, Ravi V, Yamasaki S, Lee A, Lian M, Tay B, et al. Evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). Proc Natl Acad Sci U S A. 2013;110:16044-9 pubmed publisher
    ..Such a relationship suggests that the first two rounds of genome duplication may have occurred independently in the lamprey and gnathostome lineages. ..
  7. van der Hoeven F, Sordino P, Fraudeau N, Izpisua Belmonte J, Duboule D. Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex. Mech Dev. 1996;54:9-21 pubmed
    ..In this model, a few ancestral Hox genes were involved in the determination of polarity in the digestive tract and were further recruited in more elaborate axial structures. ..
  8. Ahn D, Ho R. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Dev Biol. 2008;322:220-33 pubmed publisher
    ..Our results suggest that, although simpler in organization, teleost fins do have a distal structure that might be considered comparable to the autopod region of limbs. ..
  9. Schneider I, Aneas I, Gehrke A, Dahn R, Nobrega M, Shubin N. Appendage expression driven by the Hoxd Global Control Region is an ancient gnathostome feature. Proc Natl Acad Sci U S A. 2011;108:12782-6 pubmed publisher
    ..Our results support the notion that some of the novelties associated with tetrapod limbs arose by modification of deeply conserved cis- and trans-acting mechanisms of Hox regulation in gnathostomes. ..

More Information

Publications16

  1. Gehrke A, Schneider I, de la Calle Mustienes E, Tena J, Gómez Marín C, Chandran M, et al. Deep conservation of wrist and digit enhancers in fish. Proc Natl Acad Sci U S A. 2015;112:803-8 pubmed publisher
    ..These functional genomic data support the hypothesis that the distal radials of bony fish are homologous to the wrist and/or digits of tetrapods. ..
  2. Schüttler A, Reiche K, Altenburger R, Busch W. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Toxicol Sci. 2017;157:291-304 pubmed publisher
    ..In future, improved time- and concentration-resolved experiments should offer better understanding of stress response patterns and access to mechanistic information. ..
  3. Herault Y, Hraba Renevey S, van der Hoeven F, Duboule D. Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996;15:6727-38 pubmed
    ..These results show that, in limbs, Evx-2 functions like a Hoxd gene. A potential evolutionary scenario is discussed, in which Evx-2 was recruited by the HoxD complex in conjunction with the emergence of digits in an ancestral tetrapod. ..
  4. Fischer S, Draper B, Neumann C. The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Development. 2003;130:3515-24 pubmed
    ..We also show that fgf24 activity is necessary for the migration of tbx5-expressing cells to the fin bud, and for the activation of shh, but not hand2, expression in the posterior fin bud. ..
  5. Lavoie H, Debeane F, Trinh Q, Turcotte J, Corbeil Girard L, Dicaire M, et al. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Hum Mol Genet. 2003;12:2967-79 pubmed
  6. Crow K, Smith C, Cheng J, Wagner G, Amemiya C. An independent genome duplication inferred from Hox paralogs in the American paddlefish--a representative basal ray-finned fish and important comparative reference. Genome Biol Evol. 2012;4:937-53 pubmed publisher
  7. Stark B, Cooper J. Differential expression of CARMIL-family genes during zebrafish development. Cytoskeleton (Hoboken). 2015;72:534-41 pubmed publisher
    ..These results provide new tools and offer insight into understanding the role of the regulation of actin assembly dynamics during embryonic development and tissue morphogenesis. ..