Gene Symbol: hoxd11a
Description: homeobox D11a
Alias: fk50b10, hoxc11, hoxd-11, hoxd11, sb:eu641, wu:fk50b10, homeobox protein Hox-D11a, homeo box D11a, homeobox gene D-11, homeobox protein Hox-C11, hox-C11, hox-D11
Species: zebrafish
Products:     hoxd11a

Top Publications

  1. Gibert Y, Gajewski A, Meyer A, Begemann G. Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling. Development. 2006;133:2649-59 pubmed
    ..Thus, RA signaling from flanking somites plays a dual early role in the condensing limb bud mesenchyme. ..
  2. Yelon D, Ticho B, Halpern M, Ruvinsky I, Ho R, Silver L, et al. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development. 2000;127:2573-82 pubmed
    ..Thus, these studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development. ..
  3. Lavoie H, Debeane F, Trinh Q, Turcotte J, Corbeil Girard L, Dicaire M, et al. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Hum Mol Genet. 2003;12:2967-79 pubmed
  4. Crow K, Smith C, Cheng J, Wagner G, Amemiya C. An independent genome duplication inferred from Hox paralogs in the American paddlefish--a representative basal ray-finned fish and important comparative reference. Genome Biol Evol. 2012;4:937-53 pubmed publisher
  5. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..
  6. Mehta T, Ravi V, Yamasaki S, Lee A, Lian M, Tay B, et al. Evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). Proc Natl Acad Sci U S A. 2013;110:16044-9 pubmed publisher
    ..Such a relationship suggests that the first two rounds of genome duplication may have occurred independently in the lamprey and gnathostome lineages. ..
  7. Sharif F, Steenbergen P, Metz J, Champagne D. Long-lasting effects of dexamethasone on immune cells and wound healing in the zebrafish. Wound Repair Regen. 2015;23:855-65 pubmed publisher
    ..Therefore, the current findings support the use of the larval zebrafish model to study the impact of stress and stress hormone exposure in immature organisms on health risks in later life. ..
  8. Fongang B, Kudlicki A. Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. PLoS ONE. 2016;11:e0155802 pubmed publisher
    ..Our research lays the groundwork for further studies that will probe the evolution of the regulatory mechanism of segmentation across all vertebrates. ..
  9. Ahn D, Ho R. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Dev Biol. 2008;322:220-33 pubmed publisher
    ..Our results suggest that, although simpler in organization, teleost fins do have a distal structure that might be considered comparable to the autopod region of limbs. ..

More Information


  1. Sakamoto K, Onimaru K, Munakata K, Suda N, Tamura M, Ochi H, et al. Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development. PLoS ONE. 2009;4:e5121 pubmed publisher
    ..This process may have facilitated major morphological changes in paired appendages during vertebrate limb evolution. ..