Gene Symbol: hoxb5b
Description: homeobox B5b
Alias: ZF-54, ZF54, hoxa5, hoxb5-like, hoxzf54, id:ibd2566, zgc:101134, homeobox protein Hox-B5b, etID309875.12, homeo box B5b, homeobox gene A-5, homeobox gene zf54, homeobox protein Zf-54
Species: zebrafish

Top Publications

  1. Waxman J, Yelon D. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Dev Biol. 2011;352:128-40 pubmed publisher
    ..Taking into account studies of RA signaling in tunicates and tetrapods, we propose a parsimonious model of the evolution of RAR function during chordate anterior-posterior patterning. ..
  2. Waxman J, Keegan B, Roberts R, Poss K, Yelon D. Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. Dev Cell. 2008;15:923-34 pubmed publisher
    ..b>hoxb5b, an RA-responsive gene expressed within the forelimb field, is required to restrict the number of atrial cells ..
  3. Jarinova O, Hatch G, Poitras L, Prudhomme C, Grzyb M, Aubin J, et al. Functional resolution of duplicated hoxb5 genes in teleosts. Development. 2008;135:3543-53 pubmed publisher
    ..Zebrafish have two hoxb complexes, with two hoxb5 genes, hoxb5a and hoxb5b, the expression patterns of which suggest subfunctionalization of an ancestral hoxb5 gene...
  4. Waxman J, Yelon D. Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling. Dev Dyn. 2009;238:1207-13 pubmed publisher
    ..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart. ..
  5. Ishioka A, Jindo T, Kawanabe T, Hatta K, Parvin M, Nikaido M, et al. Retinoic acid-dependent establishment of positional information in the hindbrain was conserved during vertebrate evolution. Dev Biol. 2011;350:154-68 pubmed publisher
    ..Possible implications in vertebrate evolution are discussed based on these findings. ..
  6. D Aniello E, Ravisankar P, Waxman J. Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS ONE. 2015;10:e0138588 pubmed publisher
    ..Altogether, our results demonstrate that Rdh10a has a conserved requirement in the first step of RA production within vertebrate embryos. ..
  7. Oliveira E, Casado M, Raldua D, Soares A, Barata C, Pina B. Retinoic acid receptors' expression and function during zebrafish early development. J Steroid Biochem Mol Biol. 2013;138:143-51 pubmed publisher
    ..did not affect the response to exogenous RA of the known RAR-responsive genes cyp26a1, dhrs3a, hoxb1b, hoxb5a, and hoxb5b. At the transcriptomic level, RA treatment elicited a negative feedback of genes involved in the endogenous RA ..
  8. Raincrow J, Dewar K, Stocsits C, Prohaska S, Amemiya C, Stadler P, et al. Hox clusters of the bichir (Actinopterygii, Polypterus senegalus) highlight unique patterns of sequence evolution in gnathostome phylogeny. J Exp Zool B Mol Dev Evol. 2011;316:451-64 pubmed publisher
    ..Taken together, our results suggest that actinopterygian Hox gene clusters experienced a reduction in selective constraints that surprisingly predates the teleost-specific genome duplication. ..
  9. Zou S, Jiang X, He Z, Yuan J, Yuan X, Li S. Hox gene clusters in blunt snout bream, Megalobrama amblycephala and comparison with those of zebrafish, fugu and medaka genomes. Gene. 2007;400:60-70 pubmed
    ..Additionally, the relationship between the decrease of GC level and the loss of conservation and function of one of the paralogous genes from twin clusters is discussed. ..

More Information


  1. Bruce A, Oates A, Prince V, Ho R. Additional hox clusters in the zebrafish: divergent expression patterns belie equivalent activities of duplicate hoxB5 genes. Evol Dev. 2001;3:127-44 pubmed
    ..address the role of these additional zebrafish hox genes, we have examined the duplicate hoxB5 genes, hoxB5a, and hoxB5b. Conservation of gene duplicates can occur when one gene acquires a new function (neofunctionalization), or when ..
  2. Chen J, Carney S, Peterson R, Heideman W. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Physiol Genomics. 2008;33:148-58 pubmed publisher
    ..Among the genes rapidly induced by RA was Nr2F5, a member of the COUP-TF family of transcriptional repressors. We found that induction of Nr2F5 was both necessary and sufficient for the cardiotoxic response to RA. ..
  3. Woltering J, Durston A. The zebrafish hoxDb cluster has been reduced to a single microRNA. Nat Genet. 2006;38:601-2 pubmed
  4. Crow K, Stadler P, Lynch V, Amemiya C, Wagner G. The "fish-specific" Hox cluster duplication is coincident with the origin of teleosts. Mol Biol Evol. 2006;23:121-36 pubmed
    ..Taken together, these results support the notion that the duplicated Hox genes of teleosts were causally relevant to adaptive evolution during the initial teleost radiation. ..
  5. Liang D, Jia W, Li J, Li K, Zhao Q. Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS ONE. 2012;7:e30865 pubmed publisher
    ..Taken together, our results demonstrate that RA signaling restricts zebrafish primitive myelopoiesis through acting downstream of gata4/5/6, upstream of, or parallel to, cloche, and upstream of scl. ..
  6. Weicksel S, Xu J, SAGERSTROM C. Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis. PLoS ONE. 2013;8:e63175 pubmed publisher
  7. Davidson A, Ernst P, Wang Y, Dekens M, Kingsley P, Palis J, et al. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003;425:300-6 pubmed
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis. ..
  8. Hortopan G, Baraban S. Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish. Dev Dyn. 2011;240:1964-76 pubmed publisher
    ..Here, we selected nine of these genes (her4.2, hes5, bhlhb5, hoxa5a, hoxb5b, dmbx1a, dbx1a, nxph1, and plxnd1) and performed a more thorough analysis of expression using conventional ..
  9. Amores A, Suzuki T, Yan Y, Pomeroy J, Singer A, Amemiya C, et al. Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Genome Res. 2004;14:1-10 pubmed
  10. D Aniello E, Rydeen A, Anderson J, Mandal A, Waxman J. Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. PLoS Genet. 2013;9:e1003689 pubmed publisher
    ..Our results support an intriguing novel mechanism by which depletion of RARs elicits a previously unrecognized positive feedback loop that can result in developmental defects due to teratogenic increases in embryonic RA...
  11. Rydeen A, Voisin N, D Aniello E, Ravisankar P, Devignes C, Waxman J. Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling. Dev Biol. 2015;405:47-55 pubmed publisher
    ..Therefore, our results provide novel insights into the teratogenic mechanisms of RA signaling and the cellular mechanisms by which Cyp26a1 expression can shape a RA gradient. ..