hoxb1b

Summary

Gene Symbol: hoxb1b
Description: homeobox B1b
Alias: Hoxa-1, cb249, hoxa1, id:ibd5001, homeobox protein Hox-B1b, homeo box B1b, homeobox gene A-1, homeobox protein Hox-A1, hox-A1
Species: zebrafish

Top Publications

  1. pmc TALE factors poise promoters for activation by Hox proteins
    Seong Kyu Choe
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Cell 28:203-11. 2014
  2. pmc RNA-seq-based mapping and candidate identification of mutations from forward genetic screens
    Adam C Miller
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 23:679-86. 2013
  3. ncbi The zebrafish hoxDb cluster has been reduced to a single microRNA
    Joost M Woltering
    Nat Genet 38:601-2. 2006
  4. ncbi Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction
    Eric R Londin
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Dev Biol 279:1-19. 2005
  5. ncbi FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer
    Shingo Maegawa
    Department of Biology, University of Pennsylvania, Goddard Labs 316, Philadelphia, PA 19104 6017, USA
    Development 133:3265-76. 2006
  6. pmc Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:3581-92. 2004
  7. doi Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization
    Birgit Kagermeier-Schenk
    Biotechnology Center and Center for Regenerative Therapies, Technische Universitat Dresden, Tatzberg 47, 01307 Dresden, Germany
    Dev Cell 21:1129-43. 2011
  8. pmc Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis
    Steven E Weicksel
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 8:e63175. 2013
  9. pmc Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo
    Richard J White
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
    PLoS Biol 5:e304. 2007
  10. ncbi An early Fgf signal required for gene expression in the zebrafish hindbrain primordium
    Nicole M Roy
    Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, 364 Plantation Street LRB 822, Worcester, MA 01605, USA
    Brain Res Dev Brain Res 148:27-42. 2004

Research Grants

  1. Specification and Positioning of the Pancreas
    CHARLES SAGERSTROM; Fiscal Year: 2005
  2. MOLECULAR ANALYSIS OF HINDBRAIN FORMATION
    CHARLES SAGERSTROM; Fiscal Year: 2007

Scientific Experts

  • Tetsuhiro Kudoh
  • CHARLES SAGERSTROM
  • Adam C Miller
  • J J Essner
  • Lisa Maves
  • Joost M Woltering
  • Muriel Rhinn
  • Máté Varga
  • Eric R Londin
  • Seong Kyu Choe
  • Steven E Weicksel
  • Anming Meng
  • Victoria E Prince
  • Yu Huan Shih
  • Jue Zhao
  • Chris T Dee
  • Hiroyuki Takeda
  • Shunji Jia
  • Shingo Maegawa
  • John Postlethwait
  • Mihaela Zigman
  • Xiaozhi Rong
  • Xiaofeng Xu
  • Mary C Mullins
  • Zhihui Sun
  • Eva Oliveira
  • Lee D Kapp
  • Megumi Hashiguchi
  • Jian Meng Cao
  • Alam Khan
  • Kyo Yamasu
  • Akiko Ishioka
  • Shengnan Hu
  • N Vlachakis
  • Rafael G Almeida
  • Jeremy D Raincrow
  • Birgit Kagermeier-Schenk
  • Ying Cao
  • Willem M R van den Akker
  • Carlos Cruz
  • Hanbing Zhong
  • Kou Peng
  • Stephanie M Bingham
  • Enrico Vaccari
  • Igor B Dawid
  • Aline Stedman
  • Caroline S Hirst
  • Paul J Scotting
  • Hyunju Ro
  • Fang Xu
  • Sutada Mungpakdee
  • Eric S Weinberg
  • Richard J White
  • Stefan Hans
  • Imogen A Hurley
  • Wuhong Pei
  • Masataka Nikaido
  • Bo Xiong
  • Iban Seiliez
  • Stephen W Wilson
  • Isabelle Foucher
  • Corinne Houart
  • Ricardo G Correa
  • Fabian Rentzsch
  • Angel Amores
  • Melina E Hale
  • Nicole M Roy
  • Mazen A Kheirbek
  • Denise A Zannino
  • Scot A Wolfe
  • Chen Chen
  • Motoyuki Itoh
  • Sumito Koshida
  • Cunming Duan
  • Shanshan Ma
  • Franck Ladam
  • Chen Luo
  • Cecilia B Moens
  • James M McClintock
  • Yumei Zhou
  • Ling Lu
  • Heiner Grandel
  • Nico Laumann-Lipp
  • Stefan Schulte-Merker
  • Lei Sun
  • Yun Li
  • Tom Titus
  • Ying He
  • Yunzhang Liu
  • Ankit Gupta

Detail Information

Publications67

  1. pmc TALE factors poise promoters for activation by Hox proteins
    Seong Kyu Choe
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Cell 28:203-11. 2014
    ..Examining a Hoxb1b:TALE complex that regulates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the ..
  2. pmc RNA-seq-based mapping and candidate identification of mutations from forward genetic screens
    Adam C Miller
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 23:679-86. 2013
    ..Overall, we show that RNA-seq is a fast, reliable, and cost-effective method to map and identify mutations that will greatly facilitate the power of forward genetics in vertebrate models...
  3. ncbi The zebrafish hoxDb cluster has been reduced to a single microRNA
    Joost M Woltering
    Nat Genet 38:601-2. 2006
  4. ncbi Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction
    Eric R Londin
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Dev Biol 279:1-19. 2005
    ..Our results support a model in which specification of anterior neural tissue requires early FGF-mediated repression of BMP transcript levels and later activities of Chordin and mesodermal factors...
  5. ncbi FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer
    Shingo Maegawa
    Department of Biology, University of Pennsylvania, Goddard Labs 316, Philadelphia, PA 19104 6017, USA
    Development 133:3265-76. 2006
    ....
  6. pmc Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:3581-92. 2004
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue...
  7. doi Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization
    Birgit Kagermeier-Schenk
    Biotechnology Center and Center for Regenerative Therapies, Technische Universitat Dresden, Tatzberg 47, 01307 Dresden, Germany
    Dev Cell 21:1129-43. 2011
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells...
  8. pmc Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis
    Steven E Weicksel
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 8:e63175. 2013
    ....
  9. pmc Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo
    Richard J White
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
    PLoS Biol 5:e304. 2007
    ..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner...
  10. ncbi An early Fgf signal required for gene expression in the zebrafish hindbrain primordium
    Nicole M Roy
    Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, 364 Plantation Street LRB 822, Worcester, MA 01605, USA
    Brain Res Dev Brain Res 148:27-42. 2004
    ..Our results demonstrate an early role for Fgf signaling and reveal a dynamic relationship between the RA and Fgf signaling pathways during hindbrain development...
  11. pmc Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis
    Mihaela Zigman
    Centre for Organismal Studies COS, University of Heidelberg, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany
    Development 141:639-49. 2014
    ..We unveil a non-classical role for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented ..
  12. ncbi Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
    Development 129:4335-46. 2002
    ..When the posterior neural gene hoxb1b is expressed during gastrulation, it shows a strikingly complementary pattern to cyp26...
  13. ncbi Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast
    S Koshida
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    Development 125:1957-66. 1998
    ..However, the requirement for FGF signalling is indirect in that cells with compromised ability to respond to FGF can still respond to anteroposterior positional information...
  14. ncbi Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention
    James M McClintock
    Committee on Developmental Biology, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA
    Development 129:2339-54. 2002
    ..knockdown approach to investigate the functions of a pair of zebrafish Hox gene duplicates, hoxb1a and hoxb1b, which are expressed during development of the hindbrain...
  15. doi Retinoic acid-dependent establishment of positional information in the hindbrain was conserved during vertebrate evolution
    Akiko Ishioka
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama City, Saitama 338 8570, Japan
    Dev Biol 350:154-68. 2011
    Zebrafish hoxb1b is expressed during epiboly in the posterior neural plate, with its anterior boundary at the prospective r4 region providing a positional cue for hindbrain formation...
  16. pmc Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like
    Hyunju Ro
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2425, USA
    Nat Cell Biol 11:1121-7. 2009
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo...
  17. ncbi Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish
    N Vlachakis
    Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Development 128:1299-312. 2001
    ..Here we demonstrate that Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish...
  18. ncbi A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b
    N Vlachakis
    Department of Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Dyn 217:109-19. 2000
    ..pbx4 expression overlaps with that of two other homeobox genes, hoxb1b and meis3, in the region of the presumptive caudal hindbrain during gastrula stages...
  19. ncbi Bmp activity establishes a gradient of positional information throughout the entire neural plate
    K A Barth
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:4977-87. 1999
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm...
  20. pmc Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos
    Carlos Cruz
    School of Biosciences, University of Exeter, Devon EX4 4SP, UK
    Proc Natl Acad Sci U S A 107:3564-9. 2010
    ..We conclude that eve1 is crucial for the organization of the antero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting activity...
  21. pmc Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis
    Seong Kyu Choe
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB822, Worcester, MA 01605, USA
    Dev Cell 17:561-7. 2009
    ..We conclude that Meis acts, at least in part, by controlling access of HDAC and CBP to Hox-regulated promoters...
  22. ncbi Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Dev Biol 285:593-605. 2005
    ..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
  23. doi Maternal Vsx1 plays an essential role in regulating prechordal mesendoderm and forebrain formation in zebrafish
    Xiaofeng Xu
    College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China
    Dev Biol 394:264-76. 2014
    ..Our results reveal a pivotal role for maternal Vsx1 as a direct transcriptional repressor of ntl expression at the margin of the zebrafish gastrula to ensure directional cell polarization and migration of PME cells. ..
  24. ncbi Variable Meis-dependence among paralog group-1 Hox proteins
    Seong Kyu Choe
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
    Biochem Biophys Res Commun 331:1384-91. 2005
    ..Misexpression of Hoxb1a induces ectopic gene expression throughout the anterior nervous system, while Hoxb1b induces ectopic expression primarily in hindbrain rhombomere 2...
  25. ncbi Overexpression of thyroid hormone receptor alpha 1 during zebrafish embryogenesis disrupts hindbrain patterning and implicates retinoic acid receptors in the control of hox gene expression
    J J Essner
    Department of Genetics and Cell Biology, University of Minnesota, St Paul 55108 1095, USA
    Differentiation 65:1-11. 1999
    ..This phenotype correlated with a reduction in hoxa1 expression during gastrulation...
  26. pmc R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos
    Xiaozhi Rong
    Key Laboratory of Marine Drugs Ocean University of China, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China
    PLoS ONE 9:e99514. 2014
    ..Human RSPO3 has similar action when tested in zebrafish embryos. These results suggest that Rspo3 regulates dorsoventral and anteroposterior patterning by negatively regulating the zygotic Wnt/β-catenin signaling in zebrafish embryos. ..
  27. pmc Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish
    Steven E Weicksel
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, LRB815, Worcester, MA 01605 2324, USA
    BMC Dev Biol 14:25. 2014
    ..However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively ..
  28. ncbi Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud
    Heiner Grandel
    Max Planck Institute for Molecular Cell Biology and Genetics Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
    Development 129:2851-65. 2002
    ....
  29. pmc The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis
    Lee D Kapp
    Perelman School of Medicine at the University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 9:e1003822. 2013
    ..Our results are consistent with a novel role for Ints6 in restricting the vertebrate organizer to a dorsal domain in embryonic patterning. ..
  30. doi Retinoic acid receptors' expression and function during zebrafish early development
    Eva Oliveira
    Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research IDAEA CSIC, Jordi Girona 18, 08034 Barcelona, Spain CESAM and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    J Steroid Biochem Mol Biol 138:143-51. 2013
    ..These changes did not affect the response to exogenous RA of the known RAR-responsive genes cyp26a1, dhrs3a, hoxb1b, hoxb5a, and hoxb5b...
  31. doi Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages
    Alam Khan
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama City, Saitama 338 8570, Japan
    Mech Dev 129:219-35. 2012
    ..Collectively, these data demonstrated that pou2 regulates DV patterning and CE movement in zebrafish embryos at the midblastula and late blastula stages, respectively...
  32. doi Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish
    Shengnan Hu
    Laboratory of Molecular Cell Biology, Shanghai Key Laboratory for Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 43:387-99. 2011
    ..Taken together, Sox31 functions as an essential CNS AP patterning determinant and coordinates the CNS AP patterning process with organizer specification...
  33. pmc Individual axons regulate the myelinating potential of single oligodendrocytes in vivo
    Rafael G Almeida
    Centre for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Development 138:4443-50. 2011
    ..These data indicate that single oligodendrocytes can myelinate diverse axons and that their myelinating potential is actively regulated by individual axons...
  34. doi High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development
    Jian Meng Cao
    School of Life Sciences, Shandong University, 27 Shanda Nan Road, Jinan 250100, China
    Mech Dev 129:263-74. 2012
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development...
  35. pmc Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock
    Megumi Hashiguchi
    Department of Cell and Developmental Biology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
    Development 140:1970-80. 2013
    ..Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously...
  36. doi Hox clusters of the bichir (Actinopterygii, Polypterus senegalus) highlight unique patterns of sequence evolution in gnathostome phylogeny
    Jeremy D Raincrow
    Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
    J Exp Zool B Mol Dev Evol 316:451-64. 2011
    ..Taken together, our results suggest that actinopterygian Hox gene clusters experienced a reduction in selective constraints that surprisingly predates the teleost-specific genome duplication...
  37. pmc Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer
    Máté Varga
    Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
    BMC Dev Biol 11:26. 2011
    ..However, as impaired organizer function also results in anterior and posterior truncations, it is of interest to determine if proper anteroposterior (AP) pattern can be obtained even in the absence of early organizer signaling...
  38. doi Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish
    Kou Peng
    Laboratory of Integrated Bioscience, School of Life Science, Sun Yat Sen University, No 135 West XinGang Road, Guangzhou 510275, China
    Neurosci Lett 484:98-103. 2010
    ..Our results indicated that FoxO3a might be essential for the maintenance of neural development in zebrafish. Therefore, this work provides novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals...
  39. doi Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish
    Hanbing Zhong
    Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen, China
    Mol Biosyst 6:1463-8. 2010
    ..Our studies suggest that zebrafish should be generally useful as an efficient in vivo model to evaluate specificity of small molecules designed to regulate any conserved target proteins through comparative analysis of genetic phenotypes...
  40. doi SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling
    Yu Huan Shih
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Development 137:2671-81. 2010
    ..It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms...
  41. doi prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish
    Enrico Vaccari
    Dipartimento di Biologia, Universita degli Studi di Padova, Via Bassi 58B, Padova, Italy
    Dev Biol 343:94-103. 2010
    ..As the paralogue gene prep1.1 is more important in hindbrain patterning and neural crest chondrogenesis, we provide evidence of a functional specialization of prep genes in zebrafish head segmentation and morphogenesis...
  42. pmc MiR-10 represses HoxB1a and HoxB3a in zebrafish
    Joost M Woltering
    Institute of Biology, Leiden University, Leiden, The Netherlands
    PLoS ONE 3:e1396. 2008
    ..The members of the miR-10 family are located at positions associated with Hox-4 paralogues. No function is yet known for this microRNA family but the genomic positions of its members suggest a role in anterior-posterior patterning...
  43. pmc Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain
    Stephanie M Bingham
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Dev Neurobiol 70:87-99. 2010
    ..We tested this hypothesis by examining whether migration of motor neurons out of r2 following ectopic hoxb1b expression was affected in vangl2(-) (trilobite) mutants...
  44. doi N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling
    Fang Xu
    Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing 210061, China
    Mech Dev 126:771-80. 2009
    ..Taken together, our results demonstrate that N-CoR is essential for early hindbrain patterning by actively repressing retinoid signaling...
  45. ncbi In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning
    M Nikaido
    Department of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Development 126:181-90. 1999
    ..Taken together, we propose that, in ectodermal patterning, BMP exerts a direct and cell-autonomous effect to fate uncommitted ectodermal cells to become epidermis...
  46. ncbi Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish
    Sumito Koshida
    Division of Biological Science, Graduate School of Science, Nagoya, Chikusa ku, 464 8602, Japan
    Dev Biol 244:9-20. 2002
    ..It effectively suppressed the anterior neural marker, otx2, but not the posterior marker, hoxb1b. Furthermore, we demonstrated that the cells in the presumptive posterior neural region lose their neural fate ..
  47. ncbi A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD NIH, Bethesda, MD 20892, USA
    Development 129:2317-27. 2002
    ....
  48. pmc An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction
    Jue Zhao
    Department of Biological Sciences and Biotechnology, Protein Sciences Laboratory of the MOE, Tsinghua University, Beijing 100084, China
    EMBO J 22:6078-88. 2003
    ..We suggest that expression of spr2 is an immediate-early response to mesoderm induction by Fgfs, which in turn regulates the expression of effector genes involved in the development of mesodermal tissues...
  49. pmc Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish
    Angel Amores
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97402, USA
    Genome Res 14:1-10. 2004
    ....
  50. ncbi Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons
    Melina E Hale
    Department of Organismal Biology, Committees on Neurobiology, Computational Neurobiology, Evolutionary Biology, and Developmental Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:3070-6. 2004
    ..We suggest that such functional redundancy between neurons may provide a substrate for evolution of neural circuits...
  51. pmc Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development
    Ricardo G Correa
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Mol Cell Biol 24:5257-68. 2004
    ..Our study illustrates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early embryogenesis...
  52. ncbi fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos
    Ying Cao
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 271:130-43. 2004
    ..Like fgf8, activation of fgf17b expression depends on Nodal signaling...
  53. ncbi Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
    Fabian Rentzsch
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 231:750-7. 2004
    ....
  54. ncbi FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation
    Iban Seiliez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France
    Dev Biol 290:152-63. 2006
    ..Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a...
  55. ncbi Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
    Isabelle Foucher
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 9RT, UK
    Development 133:1891-900. 2006
    ..This maintenance is enough to allow cerebellar differentiation...
  56. ncbi Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo
    Zhihui Sun
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Dev Dyn 235:2999-3006. 2006
    ..inhibit inductive activity of ectopic Fgf signals on the expression of the posterior neuroectodermal markers gbx2, hoxb1b, and krox20...
  57. ncbi Changes in retinoic acid signaling alter otic patterning
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 134:2449-58. 2007
    ..Thus, excess RA expands otic competence, whereas the loss of RA impairs the expression of fgf3 and wnt8b in the hindbrain, compromising the induction and maintenance of otic fate...
  58. pmc An early requirement for maternal FoxH1 during zebrafish gastrulation
    Wuhong Pei
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Building 35, Room 1B 205, Bethesda, MD 20892, USA
    Dev Biol 310:10-22. 2007
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling...
  59. ncbi Consequences of hoxb1 duplication in teleost fish
    Imogen A Hurley
    Department of Organismal Biology and Anatomy, The University of Chicago, 1027 East 57th Street, IL 60637, USA
    Evol Dev 9:540-54. 2007
    ..Unexpectedly, we found that some biochemical properties, which were paralog specific in zebrafish, are conserved in both duplicates of other species. This work suggests that the fate of duplicate genes varies across the teleost group...
  60. pmc Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling
    Eric R Londin
    Department of Neurobiology and Behavior, Stony Brook University Stony Brook, New York, USA
    BMC Dev Biol 7:120. 2007
    ..The zinc-finger transcription factor, Churchill (ChCh) has been proposed to regulate cell fate by regulating cell movements during gastrulation in the chick. However, the mechanism of action of ChCh is not understood...
  61. doi Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm
    Chris T Dee
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 320:289-301. 2008
    ....
  62. doi Spatio-temporal expression patterns of anterior Hox genes in Atlantic salmon (Salmo salar)
    Sutada Mungpakdee
    Sars International Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgt 55, N 5008 Bergen, Norway
    Gene Expr Patterns 8:508-14. 2008
    ..However, changes in spatial expression were observed for the ancient fish gene duplicate HoxB3b, while recently duplicated genes showed divergence in their expression levels...
  63. pmc Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal
    Muriel Rhinn
    Biotechnology Center, and Center for Regenerative Therapies Dresden, CRTD, Dresden University of Technology, Dresden, Germany
    Neural Dev 4:12. 2009
    ..Zebrafish gbx2, on the other hand, acts relatively late at the MHB. To investigate the function of zebrafish gbx1 within the early neural plate, we used a combination of gain- and loss-of-function experiments...
  64. doi Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish
    Shunji Jia
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 333:273-84. 2009
    ..results in reduction of the anterior neuroectodermal marker otx2 as well as the posterior neuroectodermal marker hoxb1b during late gastrulation, suggesting a role of Smad2/3 activities in neural induction...
  65. doi Identification of hoxb1b downstream genes: hoxb1b as a regulatory factor controlling transcriptional networks and cell movement during zebrafish gastrulation
    Willem M R van den Akker
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
    Int J Dev Biol 54:55-62. 2010
    ..Hox proteins during early vertebrate development, we designed a strategy to identify target genes of the zebrafish hoxb1b using overexpression and whole-genome microarray analysis...
  66. ncbi Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity
    Bo Xiong
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Protein Sciences Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Cell 11:225-38. 2006
    ..We further demonstrate that Tob family members across species share similar biochemical properties and biological activities...
  67. doi A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3
    Aline Stedman
    CNRS UMR7622, Laboratoire de Biologie du Developpement, Universite Pierre et Marie Curie, Bâtiment C 7ème étage, Boite 24, 9 quai Saint Bernard, 75005 Paris, France
    Dev Biol 327:566-77. 2009
    ..Together, our data point to an essential function of Iroquois transcription factors in krox20 activation and, more generally, in anterior hindbrain specification...

Research Grants2

  1. Specification and Positioning of the Pancreas
    CHARLES SAGERSTROM; Fiscal Year: 2005
    ..abstract_text> ..
  2. MOLECULAR ANALYSIS OF HINDBRAIN FORMATION
    CHARLES SAGERSTROM; Fiscal Year: 2007
    ..complexes with Pbx proteins and histone deacetylases (HDACs) and that Meis proteins are required to convert Pbx:Hoxb1b complexes into transcriptional activators...