hoxb1b

Summary

Gene Symbol: hoxb1b
Description: homeobox B1b
Alias: Hoxa-1, cb249, hoxa1, id:ibd5001, homeobox protein Hox-B1b, homeo box B1b, homeobox gene A-1, homeobox protein Hox-A1, hox-A1
Species: zebrafish
Products:     hoxb1b

Top Publications

  1. Choe S, Ladam F, SAGERSTROM C. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014;28:203-11 pubmed publisher
    ..Examining a Hoxb1b:TALE complex that regulates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the ..
  2. Ro H, Dawid I. Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat Cell Biol. 2009;11:1121-7 pubmed publisher
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo. ..
  3. Miller A, Obholzer N, Shah A, Megason S, Moens C. RNA-seq-based mapping and candidate identification of mutations from forward genetic screens. Genome Res. 2013;23:679-86 pubmed publisher
    ..Overall, we show that RNA-seq is a fast, reliable, and cost-effective method to map and identify mutations that will greatly facilitate the power of forward genetics in vertebrate models. ..
  4. Woltering J, Durston A. The zebrafish hoxDb cluster has been reduced to a single microRNA. Nat Genet. 2006;38:601-2 pubmed
  5. Barth K, Kishimoto Y, Rohr K, Seydler C, Schulte Merker S, Wilson S. Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development. 1999;126:4977-87 pubmed
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm. ..
  6. Maves L, Kimmel C. Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev Biol. 2005;285:593-605 pubmed
    ..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
  7. Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells. ..
  8. White R, Nie Q, Lander A, Schilling T. Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. PLoS Biol. 2007;5:e304 pubmed
    ..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner. ..
  9. Choe S, Lu P, Nakamura M, Lee J, SAGERSTROM C. Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell. 2009;17:561-7 pubmed publisher
    ..We conclude that Meis acts, at least in part, by controlling access of HDAC and CBP to Hox-regulated promoters. ..
  10. Roy N, SAGERSTROM C. An early Fgf signal required for gene expression in the zebrafish hindbrain primordium. Brain Res Dev Brain Res. 2004;148:27-42 pubmed
    ..Our results demonstrate an early role for Fgf signaling and reveal a dynamic relationship between the RA and Fgf signaling pathways during hindbrain development. ..

Detail Information

Publications73

  1. Choe S, Ladam F, SAGERSTROM C. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014;28:203-11 pubmed publisher
    ..Examining a Hoxb1b:TALE complex that regulates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the ..
  2. Ro H, Dawid I. Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat Cell Biol. 2009;11:1121-7 pubmed publisher
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo. ..
  3. Miller A, Obholzer N, Shah A, Megason S, Moens C. RNA-seq-based mapping and candidate identification of mutations from forward genetic screens. Genome Res. 2013;23:679-86 pubmed publisher
    ..Overall, we show that RNA-seq is a fast, reliable, and cost-effective method to map and identify mutations that will greatly facilitate the power of forward genetics in vertebrate models. ..
  4. Woltering J, Durston A. The zebrafish hoxDb cluster has been reduced to a single microRNA. Nat Genet. 2006;38:601-2 pubmed
  5. Barth K, Kishimoto Y, Rohr K, Seydler C, Schulte Merker S, Wilson S. Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development. 1999;126:4977-87 pubmed
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm. ..
  6. Maves L, Kimmel C. Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev Biol. 2005;285:593-605 pubmed
    ..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
  7. Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells. ..
  8. White R, Nie Q, Lander A, Schilling T. Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. PLoS Biol. 2007;5:e304 pubmed
    ..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner. ..
  9. Choe S, Lu P, Nakamura M, Lee J, SAGERSTROM C. Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell. 2009;17:561-7 pubmed publisher
    ..We conclude that Meis acts, at least in part, by controlling access of HDAC and CBP to Hox-regulated promoters. ..
  10. Roy N, SAGERSTROM C. An early Fgf signal required for gene expression in the zebrafish hindbrain primordium. Brain Res Dev Brain Res. 2004;148:27-42 pubmed
    ..Our results demonstrate an early role for Fgf signaling and reveal a dynamic relationship between the RA and Fgf signaling pathways during hindbrain development. ..
  11. Kudoh T, Wilson S, Dawid I. Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Development. 2002;129:4335-46 pubmed
    ..When the posterior neural gene hoxb1b is expressed during gastrulation, it shows a strikingly complementary pattern to cyp26...
  12. McClintock J, Kheirbek M, Prince V. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002;129:2339-54 pubmed
    ..knockdown approach to investigate the functions of a pair of zebrafish Hox gene duplicates, hoxb1a and hoxb1b, which are expressed during development of the hindbrain...
  13. Zigman M, Laumann Lipp N, Titus T, Postlethwait J, Moens C. Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development. 2014;141:639-49 pubmed publisher
    ..We unveil a non-classical role for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented ..
  14. Koshida S, Shinya M, Mizuno T, Kuroiwa A, Takeda H. Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast. Development. 1998;125:1957-66 pubmed
    ..However, the requirement for FGF signalling is indirect in that cells with compromised ability to respond to FGF can still respond to anteroposterior positional information. ..
  15. Weicksel S, Xu J, SAGERSTROM C. Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis. PLoS ONE. 2013;8:e63175 pubmed publisher
  16. Cruz C, Maegawa S, Weinberg E, Wilson S, Dawid I, Kudoh T. Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos. Proc Natl Acad Sci U S A. 2010;107:3564-9 pubmed publisher
    ..We conclude that eve1 is crucial for the organization of the antero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting activity...
  17. Kudoh T, Concha M, Houart C, Dawid I, Wilson S. Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development. 2004;131:3581-92 pubmed
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue. ..
  18. Londin E, Niemiec J, Sirotkin H. Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction. Dev Biol. 2005;279:1-19 pubmed
    ..Our results support a model in which specification of anterior neural tissue requires early FGF-mediated repression of BMP transcript levels and later activities of Chordin and mesodermal factors. ..
  19. Vlachakis N, Ellstrom D, Sagerstrom C. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b. Dev Dyn. 2000;217:109-19 pubmed
    ..pbx4 expression overlaps with that of two other homeobox genes, hoxb1b and meis3, in the region of the presumptive caudal hindbrain during gastrula stages...
  20. Ishioka A, Jindo T, Kawanabe T, Hatta K, Parvin M, Nikaido M, et al. Retinoic acid-dependent establishment of positional information in the hindbrain was conserved during vertebrate evolution. Dev Biol. 2011;350:154-68 pubmed publisher
    Zebrafish hoxb1b is expressed during epiboly in the posterior neural plate, with its anterior boundary at the prospective r4 region providing a positional cue for hindbrain formation...
  21. Vlachakis N, Choe S, Sagerstrom C. Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish. Development. 2001;128:1299-312 pubmed
    ..Here we demonstrate that Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish...
  22. Maegawa S, Varga M, Weinberg E. FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. Development. 2006;133:3265-76 pubmed
  23. Kim H, Lee M, Jeong Y, Ro H, Kim D, Shin Y, et al. Ottogi Inhibits Wnt/?-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017;7:13278 pubmed publisher
    ..Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. ..
  24. Nikaido M, Acedo J, Hatta K, Piotrowski T. Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish. Dev Biol. 2017;431:215-225 pubmed publisher
    ..This is the first report that the aLLp and pLLp depend on different inductive mechanisms and that pLLp induction requires the inhibition of Fgf, Wnt and Bmp signaling. ..
  25. Zhong H, Xin S, Zhao Y, Lu J, Li S, Gong J, et al. Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Mol Biosyst. 2010;6:1463-8 pubmed publisher
  26. Cao Y, Zhao J, Sun Z, Zhao Z, Postlethwait J, Meng A. fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev Biol. 2004;271:130-43 pubmed
    ..Like fgf8, activation of fgf17b expression depends on Nodal signaling. ..
  27. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling. ..
  28. Rentzsch F, Bakkers J, Kramer C, Hammerschmidt M. Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Dev Dyn. 2004;231:750-7 pubmed
  29. Koshida S, Shinya M, Nikaido M, Ueno N, Schulte Merker S, Kuroiwa A, et al. Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish. Dev Biol. 2002;244:9-20 pubmed
    ..It effectively suppressed the anterior neural marker, otx2, but not the posterior marker, hoxb1b. Furthermore, we demonstrated that the cells in the presumptive posterior neural region lose their neural fate ..
  30. Wang Y, Zhong H, Wang C, Gao D, Zhou Y, Zuo Z. Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae. Ecotoxicol Environ Saf. 2016;134P1:23-30 pubmed publisher
    ..The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating WSF/Pb mediated ASD. ..
  31. van den Akker W, Durston A, Spaink H. Identification of hoxb1b downstream genes: hoxb1b as a regulatory factor controlling transcriptional networks and cell movement during zebrafish gastrulation. Int J Dev Biol. 2010;54:55-62 pubmed publisher
    ..Hox proteins during early vertebrate development, we designed a strategy to identify target genes of the zebrafish hoxb1b using overexpression and whole-genome microarray analysis...
  32. Almeida R, Czopka T, Ffrench Constant C, Lyons D. Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development. 2011;138:4443-50 pubmed publisher
    ..These data indicate that single oligodendrocytes can myelinate diverse axons and that their myelinating potential is actively regulated by individual axons. ..
  33. Choe S, SAGERSTROM C. Variable Meis-dependence among paralog group-1 Hox proteins. Biochem Biophys Res Commun. 2005;331:1384-91 pubmed
    ..Misexpression of Hoxb1a induces ectopic gene expression throughout the anterior nervous system, while Hoxb1b induces ectopic expression primarily in hindbrain rhombomere 2...
  34. Itoh M, Kudoh T, Dedekian M, Kim C, Chitnis A. A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development. 2002;129:2317-27 pubmed
  35. Rong X, Chen C, Zhou P, Zhou Y, Li Y, Lu L, et al. R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/?-catenin signaling in zebrafish embryos. PLoS ONE. 2014;9:e99514 pubmed publisher
    ..Human RSPO3 has similar action when tested in zebrafish embryos. These results suggest that Rspo3 regulates dorsoventral and anteroposterior patterning by negatively regulating the zygotic Wnt/?-catenin signaling in zebrafish embryos. ..
  36. Sarmah S, Muralidharan P, Curtis C, McClintick J, Buente B, Holdgrafer D, et al. Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects. Biol Open. 2013;2:1013-21 pubmed publisher
  37. Hu S, Wu Z, Yan Y, Li Y. Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish. Acta Biochim Biophys Sin (Shanghai). 2011;43:387-99 pubmed publisher
    ..Taken together, Sox31 functions as an essential CNS AP patterning determinant and coordinates the CNS AP patterning process with organizer specification. ..
  38. Dee C, Hirst C, Shih Y, Tripathi V, Patient R, Scotting P. Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm. Dev Biol. 2008;320:289-301 pubmed publisher
  39. Ma Y, Liu X, Liu Z, Wei S, Shang H, Xue Y, et al. The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J Neurosci. 2015;35:8493-506 pubmed publisher
    ..We propose that Bptf and TGF-β/Smad2 mediate nucleosome remodeling to regulate wnt8a expression and hence neural posteriorization. ..
  40. Hans S, Westerfield M. Changes in retinoic acid signaling alter otic patterning. Development. 2007;134:2449-58 pubmed
    ..Thus, excess RA expands otic competence, whereas the loss of RA impairs the expression of fgf3 and wnt8b in the hindbrain, compromising the induction and maintenance of otic fate. ..
  41. Weicksel S, Gupta A, Zannino D, Wolfe S, SAGERSTROM C. Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish. BMC Dev Biol. 2014;14:25 pubmed publisher
    ..However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively ..
  42. Kapp L, Abrams E, Marlow F, Mullins M. The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. PLoS Genet. 2013;9:e1003822 pubmed publisher
    ..Our results are consistent with a novel role for Ints6 in restricting the vertebrate organizer to a dorsal domain in embryonic patterning...
  43. Grandel H, Lun K, Rauch G, Rhinn M, Piotrowski T, Houart C, et al. Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development. 2002;129:2851-65 pubmed
  44. Varga M, Maegawa S, Weinberg E. Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Dev Biol. 2011;11:26 pubmed publisher
    ..We also show that the zebrafish embryo can form a radial diffuse neural sheath in the absence of both BMP signaling and the early organizer. ..
  45. Seiliez I, Thisse B, Thisse C. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Dev Biol. 2006;290:152-63 pubmed
    ..Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a. ..
  46. Xiong C, Liu X, Meng A. The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo. J Biol Chem. 2015;290:25512-21 pubmed publisher
    ..Therefore, different isoforms of Araf may participate in similar developmental processes but by regulating different signaling pathways. ..
  47. Sun Z, Zhao J, Zhang Y, Meng A. Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo. Dev Dyn. 2006;235:2999-3006 pubmed
    ..inhibit inductive activity of ectopic Fgf signals on the expression of the posterior neuroectodermal markers gbx2, hoxb1b, and krox20...
  48. zhan G, Sezgin E, Wehner D, Pfister A, K hl S, Kagermeier Schenk B, et al. Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013;26:331-45 pubmed publisher
    ..Thus, Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling...
  49. Bingham S, Sittaramane V, Mapp O, Patil S, Prince V, Chandrasekhar A. Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Dev Neurobiol. 2010;70:87-99 pubmed publisher
    ..We tested this hypothesis by examining whether migration of motor neurons out of r2 following ectopic hoxb1b expression was affected in vangl2(-) (trilobite) mutants...
  50. Xu F, Li K, Tian M, Hu P, Song W, Chen J, et al. N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mech Dev. 2009;126:771-80 pubmed publisher
    ..Taken together, our results demonstrate that N-CoR is essential for early hindbrain patterning by actively repressing retinoid signaling. ..
  51. Peng K, Li Y, Long L, Li D, Jia Q, Wang Y, et al. Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neurosci Lett. 2010;484:98-103 pubmed publisher
    ..Our results indicated that FoxO3a might be essential for the maintenance of neural development in zebrafish. Therefore, this work provides novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals. ..
  52. Cao J, Li S, Zhang H, Shi D. High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech Dev. 2012;129:263-74 pubmed publisher
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development. ..
  53. Hurley I, Scemama J, Prince V. Consequences of hoxb1 duplication in teleost fish. Evol Dev. 2007;9:540-54 pubmed
    ..Unexpectedly, we found that some biochemical properties, which were paralog specific in zebrafish, are conserved in both duplicates of other species. This work suggests that the fate of duplicate genes varies across the teleost group. ..
  54. Shih Y, Kuo C, Hirst C, Dee C, Liu Y, Laghari Z, et al. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. Development. 2010;137:2671-81 pubmed publisher
    ..It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms. ..
  55. Nikaido M, Tada M, Takeda H, Kuroiwa A, Ueno N. In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning. Development. 1999;126:181-90 pubmed
    ..Taken together, we propose that, in ectodermal patterning, BMP exerts a direct and cell-autonomous effect to fate uncommitted ectodermal cells to become epidermis. ..
  56. Tanaka S, Hosokawa H, Weinberg E, Maegawa S. Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish. Dev Biol. 2017;424:189-197 pubmed publisher
    ..In conclusion, activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b expression levels. ..
  57. Londin E, Mentzer L, Sirotkin H. Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. BMC Dev Biol. 2007;7:120 pubmed
    ..These findings reveal a dynamic role for chch in regulating cell movement and fate during early development. ..
  58. Mungpakdee S, Seo H, Chourrout D. Spatio-temporal expression patterns of anterior Hox genes in Atlantic salmon (Salmo salar). Gene Expr Patterns. 2008;8:508-14 pubmed publisher
    ..However, changes in spatial expression were observed for the ancient fish gene duplicate HoxB3b, while recently duplicated genes showed divergence in their expression levels. ..
  59. Rhinn M, Lun K, Ahrendt R, Geffarth M, Brand M. Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev. 2009;4:12 pubmed publisher
    ..In addition to its role in MHB formation, we have shown that gbx1 is a novel mediator of Wnt8 signaling during hindbrain patterning. ..
  60. Amores A, Suzuki T, Yan Y, Pomeroy J, Singer A, Amemiya C, et al. Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Genome Res. 2004;14:1-10 pubmed
  61. Jia S, Wu D, Xing C, Meng A. Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev Biol. 2009;333:273-84 pubmed publisher
    ..results in reduction of the anterior neuroectodermal marker otx2 as well as the posterior neuroectodermal marker hoxb1b during late gastrulation, suggesting a role of Smad2/3 activities in neural induction...
  62. Hashiguchi M, Mullins M. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 2013;140:1970-80 pubmed publisher
    ..Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously. ..
  63. Woltering J, Durston A. MiR-10 represses HoxB1a and HoxB3a in zebrafish. PLoS ONE. 2008;3:e1396 pubmed publisher
  64. Han X, Gui B, Xiong C, Zhao L, Liang J, Sun L, et al. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Mol Cell. 2014;55:482-94 pubmed publisher
    ..As a potential anticancer strategy, Jade-2-mediated LSD1 degradation could potentially be used in neuroblastoma cells to induce differentiation toward postmitotic neurons. ..
  65. Zhao J, Cao Y, Zhao C, Postlethwait J, Meng A. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO J. 2003;22:6078-88 pubmed
    ..We suggest that expression of spr2 is an immediate-early response to mesoderm induction by Fgfs, which in turn regulates the expression of effector genes involved in the development of mesodermal tissues. ..
  66. Khan A, Nakamoto A, Okamoto S, Tai M, Nakayama Y, Kobayashi K, et al. Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mech Dev. 2012;129:219-35 pubmed publisher
    ..Collectively, these data demonstrated that pou2 regulates DV patterning and CE movement in zebrafish embryos at the midblastula and late blastula stages, respectively...
  67. Dong X, Li J, He L, Gu C, Jia W, Yue Y, et al. Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes. J Biol Chem. 2017;292:13045-13055 pubmed publisher
    ..translation or dCas9-Eve to inhibit their transcription, the zebrafish gastrula displays reduced expression of hoxb1b, the marker gene for the posterior neuroectoderm...
  68. Foucher I, Mione M, Simeone A, Acampora D, Bally Cuif L, Houart C. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 2006;133:1891-900 pubmed
    ..This maintenance is enough to allow cerebellar differentiation. ..
  69. Correa R, Tergaonkar V, Ng J, Dubova I, Izpisua Belmonte J, Verma I. Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol Cell Biol. 2004;24:5257-68 pubmed
    ..Our study illustrates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early embryogenesis. ..
  70. Xu X, He Y, Sun L, Ma S, Luo C. Maternal Vsx1 plays an essential role in regulating prechordal mesendoderm and forebrain formation in zebrafish. Dev Biol. 2014;394:264-76 pubmed publisher
    ..Our results reveal a pivotal role for maternal Vsx1 as a direct transcriptional repressor of ntl expression at the margin of the zebrafish gastrula to ensure directional cell polarization and migration of PME cells. ..
  71. Vaccari E, Deflorian G, Bernardi E, Pauls S, Tiso N, Bortolussi M, et al. prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Dev Biol. 2010;343:94-103 pubmed publisher
    ..As the paralogue gene prep1.1 is more important in hindbrain patterning and neural crest chondrogenesis, we provide evidence of a functional specialization of prep genes in zebrafish head segmentation and morphogenesis...
  72. Raincrow J, Dewar K, Stocsits C, Prohaska S, Amemiya C, Stadler P, et al. Hox clusters of the bichir (Actinopterygii, Polypterus senegalus) highlight unique patterns of sequence evolution in gnathostome phylogeny. J Exp Zool B Mol Dev Evol. 2011;316:451-64 pubmed publisher
    ..Taken together, our results suggest that actinopterygian Hox gene clusters experienced a reduction in selective constraints that surprisingly predates the teleost-specific genome duplication. ..