hmox1a

Summary

Gene Symbol: hmox1a
Description: heme oxygenase 1a
Alias: hmox1, wu:fc27c04, zgc:65984, heme oxygenase 1, fc27c04, heme oxygenase (decycling) 1, heme oxygenase (decycling) 1a
Species: zebrafish

Top Publications

  1. Prasch A, Andreasen E, Peterson R, Heideman W. Interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hypoxia signaling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicol Sci. 2004;78:68-77 pubmed
    ..Hypoxia decreased TCDD induction of zfCYP1A mRNA, and decreased the potency of TCDD in causing edema. It is not clear whether this is mediated through competition for zfARNT2, or through other mechanisms. ..
  2. Voelker D, Vess C, Tillmann M, Nagel R, Otto G, Geisler R, et al. Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae. Aquat Toxicol. 2007;81:355-64 pubmed
    ..Six genes involved in biotransformation (cyp1a, ahr2), stress response (nfe212, maft, hmox1) and cell cycle control (fzr1) were significantly regulated...
  3. Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391-400 pubmed publisher
    ..Furthermore, we showed that morpholino-mediated knockdown of Nrf2 reduced PFOS-induced HO-1 gene expression. These findings demonstrate that Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae. ..
  4. Wang Y, Yang L, Zhou K, Zhang Y, Song Z, He S. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Genome Biol Evol. 2015;7:2970-82 pubmed publisher
    ..Overall, our study provides new insights into the adaptations and evolution of fishes in the high-altitude environment of the Tibetan Plateau and complements previous findings on the adaptations of mammals and birds to high altitudes. ..
  5. Rissone A, Weinacht K, la Marca G, Bishop K, Giocaliere E, Jagadeesh J, et al. Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. J Exp Med. 2015;212:1185-202 pubmed publisher
    ..Our results link hematopoietic cell fate in AK2 deficiency to cellular energy depletion and increased oxidative stress. This points to the potential use of antioxidants as a supportive therapeutic modality for patients with RD. ..
  6. Liu H, Gooneratne R, Huang X, Lai R, Wei J, Wang W. A rapid in vivo zebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity. Free Radic Biol Med. 2015;84:91-102 pubmed publisher
    ..Furthermore, the Nrf2-regulated genes gclc, gpx, gstp1, and hmox1 were significantly induced at 24, 48, and 72h at the highest PCB126 exposures but not in the NAC-pretreated group...
  7. Park C, Ji H, Kim S, Kil S, Lee J, Kwak S, et al. Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes. Int J Mol Med. 2017;39:960-968 pubmed publisher
    ..Our results provide insight into the preventive therapy for hearing loss caused by aminoglycoside antibiotics. ..
  8. Lisse T, Rieger S. IKK? regulates human keratinocyte migration through surveillance of the redox environment. J Cell Sci. 2017;130:975-988 pubmed publisher
    ..Thus, this indicates that IKK? promotes migration through dynamic interactions with the EGF promoter depending on the redox state within cells. ..
  9. Liao G, Li R, Chen X, Zhang W, Du S, Yuan Y. Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway. Neuroscience. 2016;331:40-51 pubmed publisher
    ..ROS generation after radiation exposure contributes to DNA damage in the zebrafish brain. VPA inhibits ROS generation by activating the Nrf2/HO-1 pathway, which improves cognitive behavior following radiation-induced neuronal injury. ..

More Information

Publications32

  1. Kawahara G, Gasperini M, Myers J, Widrick J, Eran A, Serafini P, et al. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2014;23:1869-78 pubmed publisher
    ..were found to rescue the abnormal muscle phenotype in sapje and sapje-like, while upregulating the inducible heme oxygenase 1 (Hmox1) at the protein level...
  2. Celeghin A, Benato F, Pikulkaew S, Rabbane M, Colombo L, Dalla Valle L. The knockdown of the maternal estrogen receptor 2a (esr2a) mRNA affects embryo transcript contents and larval development in zebrafish. Gen Comp Endocrinol. 2011;172:120-9 pubmed publisher
    ..These findings suggest the involvement of maternal esr2a mRNA, presumably transactivated by maternal 17?-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development. ..
  3. Dos Anjos N, Schulze T, Brack W, Val A, Schirmer K, Scholz S. Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems. Aquat Toxicol. 2011;103:46-52 pubmed publisher
    ..Therefore, the transcript expression of various potentially sensitive genes (ahr2(1), cyp1a, hmox1, hsp70, maft, mt, nfe212, gstp1 and nqo1) in fish exposed to water soluble fractions of oil (WSF) was compared...
  4. de Preux Charles A, Bise T, Baier F, Sallin P, Jazwinska A. Preconditioning boosts regenerative programmes in the adult zebrafish heart. Open Biol. 2016;6: pubmed publisher
    ..Our results open a new field of research by providing the adult zebrafish as a model system to study remote cardiac preconditioning. ..
  5. Shi G, Cui Q, Pan Y, Sheng N, Guo Y, Dai J. 6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis. Aquat Toxicol. 2017;190:53-61 pubmed publisher
    ..Our results suggest that 6:2 FTCA can cause developmental toxicity in zebrafish embryos, and that FTCAs exhibit greater toxicity than that of PFCAs. ..
  6. Holowiecki A, O Shields B, Jenny M. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicol Appl Pharmacol. 2016;311:74-87 pubmed publisher
    ..As a result of the teleost-specific genome duplication event, zebrafish have paralogs of hmox1 (hmox1a and hmox1b) and hmox2 (hmox2a and hmox2b)...
  7. Tzaneva V, Perry S. Role of endogenous carbon monoxide in the control of breathing in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2016;311:R1262-R1270 pubmed publisher
    ..This study demonstrates for the first time that CO plays an inhibitory role in the control of breathing in larval and adult zebrafish. ..
  8. Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, et al. Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell. 2013;152:504-18 pubmed publisher
    ..These findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity...
  9. Timme Laragy A, Karchner S, Franks D, Jenny M, Harbeitner R, Goldstone J, et al. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J Biol Chem. 2012;287:4609-27 pubmed publisher
    ..identified a specific role for Nrf2b as a negative regulator of several genes, including p53, cyclin G1, and heme oxygenase 1, in embryos. Nrf2a and Nrf2b exhibited different mechanisms of cross-talk with the Ahr2 signaling pathway...
  10. So J, Kim J, Yoo K, Kim H, Jung S, Choi J, et al. FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development. PLoS ONE. 2014;9:e109517 pubmed publisher
    ..Taken together, our data suggest that FIH-1 interacts with Mib E3 Ubiquitin ligase and modulates vascular development by attenuating VEGF-A signaling activity. ..
  11. Mukhopadhyay D, Srivastava R, Chattopadhyay A. Sodium fluoride generates ROS and alters transcription of genes for xenobiotic metabolizing enzymes in adult zebrafish (Danio rerio) liver: expression pattern of Nrf2/Keap1 (INrf2). Toxicol Mech Methods. 2015;25:364-73 pubmed publisher
    ..for xenobiotic metabolizing enzymes (XMEs) like cytochrome P450 1A (Cyp1A), NADPH Q Oxidase 1 (Nqo1) and Heme Oxygenase 1 (Ho-1) increased along with nuclear factor (erythroid-derived 2)-like 2 (Nrf2) whereas Kelch-like ECH-..
  12. Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
    ..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury...
  13. Tzaneva V, Perry S. Evidence for a role of heme oxygenase-1 in the control of cardiac function in zebrafish (Danio rerio) larvae exposed to hypoxia. J Exp Biol. 2016;219:1563-71 pubmed publisher
    ..We demonstrate for the first time the ability for CO to be produced in presumptive pacemaker cells of the heart where it plays an inhibitory role in setting the resting cardiac frequency...
  14. Holowiecki A, O Shields B, Jenny M. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2017;191:138-151 pubmed publisher
    b>Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway...
  15. Weil M, Scholz S, Zimmer M, Sacher F, Duis K. Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environ Toxicol Chem. 2009;28:1970-8 pubmed publisher
    ..v-maf musculoaponeurotic fibrosarcoma oncogene family protein g (avian) 1 and NF-E2-p45-related factor, and heme oxygenase 1 (hmox1)...
  16. Fuse Y, Nakajima H, Nakajima Takagi Y, Nakajima O, Kobayashi M. Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes Cells. 2015;20:590-600 pubmed publisher
    The induction of the gene encoding heme oxygenase 1 (Hmox1, HO-1) by Nrf2 is unique compared with other Nrf2 targets. We previously showed that the Nrf2a-mediated induction of zebrafish hmox1a was liver specific and transient...
  17. Knecht A, Goodale B, Truong L, Simonich M, Swanson A, Matzke M, et al. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol. 2013;271:266-75 pubmed publisher
    ..Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms...
  18. Hrubik J, Glisic B, Fa S, Pogrmic Majkic K, Andric N. Erk-Creb pathway suppresses glutathione-S-transferase pi expression under basal and oxidative stress conditions in zebrafish embryos. Toxicol Lett. 2016;240:81-92 pubmed publisher
    ..This study also provides a novel link between Erk and gstp1-2 expression, setting apart a possible differential regulation of gstp1-2 in adult and embryonic cells. ..
  19. Fuse Y, Nguyen V, Kobayashi M. Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. Toxicol Appl Pharmacol. 2016;305:136-142 pubmed publisher
    ..Based on these results, we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity. ..
  20. Parente V, Balasso S, Pompilio G, Verduci L, Colombo G, Milano G, et al. Hypoxia/reoxygenation cardiac injury and regeneration in zebrafish adult heart. PLoS ONE. 2013;8:e53748 pubmed publisher
    ..The initial decrease in ventricular function is followed by full recovery. This model more closely mimics reperfusion injury in mammals than other cardiac injury models. ..
  21. Onyiah J, Sheikh S, Maharshak N, Steinbach E, Russo S, Kobayashi T, et al. Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology. 2013;144:789-98 pubmed publisher
    ..Colonic HO-1 prevents colonic inflammation in mice. HO-1 is induced by the enteric microbiota and its homeostatic function is mediated, in part, by promoting bactericidal activities of macrophages. ..
  22. Wang L, Gallagher E. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol. 2013;266:177-86 pubmed publisher
    ..showed increased glutathione S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by ..
  23. Craven S, French D, Ye W, de Sauvage F, Rosenthal A. Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome. Blood. 2005;105:3528-34 pubmed
    ..Thus, we identify an essential role for Hspa9b in hematopoiesis and implicate both loss of HSPA9B specifically and mitochondrial dysfunction generally in the pathogenesis of the MDS. ..