Gene Symbol: hmgcs1
Description: 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Alias: zgc:56481, hydroxymethylglutaryl-CoA synthase, cytoplasmic, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
Species: zebrafish

Top Publications

  1. Passeri M, Cinaroglu A, Gao C, Sadler K. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009;49:443-52 pubmed publisher
    ..Srebp activation is required for steatosis in this model. The tractability of zebrafish genetics provides a valuable tool for dissecting the molecular pathogenesis of acute ALD. ..
  2. Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics. 2010;11:548 pubmed publisher
  3. Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 2010;11:553 pubmed publisher
    ..This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components...
  4. Lin J, Chang L, Lai C, Lin K, Lin M, Yang C, et al. Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. Zebrafish. 2015;12:271-80 pubmed publisher
    ..As these data reflect characteristic liver damage by alcohol in humans, this zebrafish animal model may serve as a powerful tool to study the pathogenesis and treatment of ALD and its related disorders in humans. ..
  5. Li P, Lahvic J, Binder V, Pugach E, Riley E, Tamplin O, et al. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015;523:468-71 pubmed publisher
    ..EETs may have clinical application in marrow or cord blood transplantation. ..
  6. Kearns C, Ravanelli A, Cooper K, Appel B. Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. J Neurosci. 2015;35:14861-71 pubmed publisher
    ..These findings suggest that Fbxw7 helps tune the amount of myelin produced during development and raise the possibility that Fbxw7 could be a target of myelin-promoting therapies. ..
  7. Zeituni E, Wilson M, Zheng X, Iglesias P, Sepanski M, Siddiqi M, et al. Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses. J Biol Chem. 2016;291:23804-23816 pubmed
    ..These data suggest that a transient increase in ER lipids is the likely mediator of the initial physiological response of intestinal enterocytes to dietary lipid. ..
  8. Porseryd T, Volkova K, Reyhanian Caspillo N, Källman T, Dinnétz P, Porsh Hällström I. Persistent Effects of Developmental Exposure to 17?-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior. Front Behav Neurosci. 2017;11:69 pubmed publisher
    ..This study represents an initial survey of the fish brain transcriptome by RNA sequencing after long-term recovery from developmental exposure to an estrogenic compound. ..
  9. Weber G, Choe S, Dooley K, Paffett Lugassy N, Zhou Y, Zon L. Mutant-specific gene programs in the zebrafish. Blood. 2005;106:521-30 pubmed

More Information


  1. Choi J, Mouillesseaux K, Wang Z, Fiji H, Kinderman S, Otto G, et al. Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Development. 2011;138:1173-81 pubmed publisher
    ..Taken together, our findings indicate that angiogenesis is differentially regulated by the HMGCR pathway via an arteriovenous-dependent requirement for protein prenylation in zebrafish and human endothelial cells. ..
  2. Zhao Y, Qin W, Zhang J, Hu Z, Tong J, Ding C, et al. HCV IRES-mediated core expression in zebrafish. PLoS ONE. 2013;8:e56985 pubmed publisher
    ..These findings demonstrate the feasibility of the zebrafish model for screening of anti-HCV drugs targeting to HCV-IRES. The zebrafish system provides a novel evidence of using zebrafish as a HCV model organism. ..
  3. Mathews E, Mawdsley D, Walker M, Hines J, Pozzoli M, Appel B. Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. J Neurosci. 2014;34:3402-12 pubmed publisher
    ..Through a forward genetic screen in zebrafish we discovered that mutation of hmgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendrocyte progenitor ..
  4. Vacaru A, Di Narzo A, Howarth D, Tsedensodnom O, Imrie D, Cinaroglu A, et al. Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech. 2014;7:823-35 pubmed publisher
    ..We conclude that a stressed UPR causes steatosis and an adaptive UPR prevents it, demonstrating that this pathway plays dichotomous roles in fatty liver disease. ..
  5. Chen Z, Ballar P, Fu Y, Luo J, Du S, Fang S. The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver. J Genet Genomics. 2014;41:357-68 pubmed publisher
    ..Together, these data indicate that gp78 plays a critical role in protecting against ER stress in liver...
  6. Dai W, Wang K, Zheng X, Chen X, Zhang W, Zhang Y, et al. High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutr Metab (Lond). 2015;12:42 pubmed publisher
    ..HFC diets-fed larvae compared to the control, whereas the expression of lipogenic molecules (acaca, fasn, srebf2, hmgcs1 and hmgcra) were decreased in the liver of HF and HFC diets-fed larvae compared to the control...
  7. Quintana A, Hernandez J, Gonzalez C. Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. PLoS ONE. 2017;12:e0180856 pubmed publisher
    ..Our analysis confirmed that mutation of hmgcs1, which encodes the first enzyme in the cholesterol synthesis pathway, results in craniofacial abnormalities via ..