Gene Symbol: hif1aa
Description: hypoxia inducible factor 1 subunit alpha a
Alias: hypoxia-inducible factor 1-alpha, HIF1A, Hif1b, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a, hypoxia-inducible factor 1 alpha A
Species: zebrafish

Top Publications

  1. Rytkönen K, Akbarzadeh A, Miandare H, Kamei H, Duan C, Leder E, et al. Subfunctionalization of cyprinid hypoxia-inducible factors for roles in development and oxygen sensing. Evolution. 2013;67:873-82 pubmed publisher
    ..These results demonstrate the subfunctionalization of cyprinid hif alpha paralogs for specialized roles in development and the hypoxic stress response. ..
  2. Elks P, van Eeden F, Dixon G, Wang X, Reyes Aldasoro C, Ingham P, et al. Activation of hypoxia-inducible factor-1? (Hif-1?) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model. Blood. 2011;118:712-22 pubmed publisher
    ..Our data demonstrate that Hif-1? regulates neutrophil function in complex ways during inflammation resolution in vivo. ..
  3. Santhakumar K, Judson E, Elks P, McKee S, Elworthy S, van Rooijen E, et al. A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis. Cancer Res. 2012;72:4017-27 pubmed publisher
    ..Taken together, our findings establish Vhl as a genuine tumor suppressor in zebrafish and offer this model as a tool to noninvasively study VHL and HIF signaling during tumorigenesis and development. ..
  4. Metelo A, Noonan H, Li X, Jin Y, Baker R, Kamentsky L, et al. Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest. 2015;125:1987-97 pubmed publisher
    ..This study demonstrates that small-molecule targeting of HIF2α improves VHL-related phenotypes in a vertebrate animal model and supports further exploration of this strategy for treating VHL disease. ..
  5. Guan L, Chi W, Xiao W, Chen L, He S. Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan Plateau in the evolution of schizothoracine fish. BMC Evol Biol. 2014;14:192 pubmed publisher
  6. Binelli A, Del Giacco L, Santo N, Bini L, Magni S, Parolini M, et al. Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in Danio rerio embryos. Nanotoxicology. 2017;11:371-381 pubmed publisher
    ..The entire dataset suggested a Trojan-horse mechanism involved in the biological impacts on Danio rerio embryos especially due to different bioaccumulation pathways and cellular targets. ..
  7. Gerri C, Marín Juez R, Marass M, Marks A, Maischein H, Stainier D. Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish. Nat Commun. 2017;8:15492 pubmed publisher
    ..Altogether, our data provide genetic evidence that Hif-1α regulates interactions between macrophages and endothelial cells starting with the mobilization of macrophages from the AGM. ..
  8. Folkerts E, Blewett T, He Y, Goss G. Alterations to Juvenile Zebrafish (Danio rerio) Swim Performance after Acute Embryonic Exposure to Sub-lethal Exposures of Hydraulic Fracturing Flowback and Produced Water. Aquat Toxicol. 2017;193:50-59 pubmed publisher
    ..Erythropoietin (epoa) but not hypoxia inducible factor (hif1aa) nor hemoglobin -ß chain (hbbe1.1) was up-regulated after either 24 or 48h FPW exposure...
  9. Kuang X, Liu C, Fang J, Ma W, Zhang J, Cui S. The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS Lett. 2016;590:2076-85 pubmed publisher

More Information


  1. Gao J, Mahapatra C, Mapes C, Khlebnikova M, Wei A, Sepúlveda M. Vascular toxicity of silver nanoparticles to developing zebrafish (Danio rerio). Nanotoxicology. 2016;10:1363-72 pubmed publisher
    ..We propose that PVP-AgNPs temporarily delay embryonic vascular development by interfering with oxygen diffusion into the egg, leading to hypoxic conditions and ER stress. ..
  2. Vettori A, Greenald D, Wilson G, Peron M, Facchinello N, Markham E, et al. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1? stabilization. Proc Natl Acad Sci U S A. 2017;114:9948-9953 pubmed publisher
    ..Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL. ..
  3. Lai Y, Lu Y, Lien H, Huang C, Hwang S. Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. Biochem J. 2016;473:2205-18 pubmed publisher
    ..These results demonstrate that Foxa1 regulates agr2 expression in the pharynx, whereas both Foxa2 and Hif1ab control agr2 expression in intestinal goblet cells to regulate maturation of these cells. ..
  4. Elks P, Brizee S, van der Vaart M, Walmsley S, van Eeden F, Renshaw S, et al. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog. 2013;9:e1003789 pubmed publisher
    ..Stabilization of Hif-1α therefore represents a potential target for therapeutic intervention against tuberculosis. ..
  5. Rytkönen K, Prokkola J, Salonen V, Nikinmaa M. Transcriptional divergence of the duplicated hypoxia-inducible factor alpha genes in zebrafish. Gene. 2014;541:60-6 pubmed publisher
  6. Wang Y, Yang L, Zhou K, Zhang Y, Song Z, He S. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Genome Biol Evol. 2015;7:2970-82 pubmed publisher
    ..Overall, our study provides new insights into the adaptations and evolution of fishes in the high-altitude environment of the Tibetan Plateau and complements previous findings on the adaptations of mammals and birds to high altitudes. ..
  7. Huang C, Chen N, Wu X, He Y, Huang C, Liu H, et al. Zebrafish let-7b acts downstream of hypoxia-inducible factor-1? to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Life Sci. 2017;171:21-29 pubmed publisher
    ..We also identified 4 novel potential HIF-1?-regulated miRNAs in zebrafish. ..