hhex

Summary

Gene Symbol: hhex
Description: hematopoietically expressed homeobox
Alias: hex, hematopoietically-expressed homeobox protein hhex, homeobox protein hex
Species: zebrafish

Top Publications

  1. ncbi Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 270:474-86. 2004
  2. pmc Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development
    Zhen Li
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Dev Biol 7:117. 2007
  3. doi Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
    Honghui Huang
    Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
    Development 135:3209-18. 2008
  4. pmc Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
    Mech Dev 128:525-35. 2012
  5. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
  6. pmc Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development
    Morgane Poulain
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 138:3557-68. 2011
  7. doi APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
  8. pmc Bmp2 signaling regulates the hepatic versus pancreatic fate decision
    Won Suk Chung
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 15:738-48. 2008
  9. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
  10. doi Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish
    Muhammad Farooq
    Department of Biological Sciences, National University of Singapore, 117543, Singapore
    Dev Biol 317:336-53. 2008

Research Grants

Scientific Experts

  • Donghun Shin
  • Laurel A Rohde
  • Zhen Li
  • Elke A Ober
  • Mary D Kinkel
  • Jinrong Peng
  • Didier Y R Stainier
  • Heather Verkade
  • Chong Hyun Shin
  • Sung Kook Hong
  • Won Suk Chung
  • Leonard I Zon
  • Carsten Stuckenholz
  • Joseph J Lancman
  • Guizhen Du
  • Huiqiang Lu
  • François Naye
  • Immacolata Porreca
  • Shu Yu Wu
  • XuBo Niu
  • Li Jan Lo
  • Zahra Tehrani
  • Sara Zucchi
  • Suyoung Kim
  • Changqing Chang
  • Robert Opitz
  • Liqin Yu
  • Keith R Anderson
  • Morgane Poulain
  • Christian Klein
  • Shuo Lin
  • P Duc Si Dong
  • Chuan Gao
  • Fei Qi
  • Ana Faro
  • Kristen Alexa
  • M X Chang
  • Enid Yi Ni Lam
  • Chisako Nakada
  • Tessa Peterkin
  • Hans Clevers
  • Wolfram Goessling
  • Muhammad Farooq
  • Emily S Noël
  • Andrew J Latimer
  • Honghui Huang
  • David Kimelman
  • Douglas C Weiser
  • Thomas Wendl
  • Zoe D Burke
  • Nelson Hsia
  • Klaus B Rohr
  • Kimberly A Dooley
  • John W Lin
  • Johannes Bischof
  • C Y Ho
  • Osama A Elsalini
  • Lili Lu
  • Keely Solomon
  • Ling Song
  • Ulupi S Jhala
  • Danhua Zhang
  • Yufeng Qin
  • Yun Yang
  • Lingfei Luo
  • Christopher V E Wright
  • Natasha Zvenigorodsky
  • Yankai Xia
  • Xinru Wang
  • Jun Ma
  • Tae Young Choi
  • Nathan Bahary
  • Young In Chi
  • Linda Setiawan
  • Prakash C Thakur
  • Wenchao Shi
  • Taiyi Kuo
  • Jialei Hu
  • Di Wu
  • Rohan K Humphrey
  • Keith P Gates
  • Hongyu Huang
  • Elena De Felice
  • Jian Hong
  • Isabelle Manfroid
  • Jimann Shin
  • K N Wallace
  • Diane S Sepich
  • Chunmei Meng
  • Matthias Hammerschmidt

Detail Information

Publications50

  1. ncbi Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    John W Lin
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Dev Biol 270:474-86. 2004
    ..Together, these findings suggest the presence of distinct ptf1a-dependent and ptf1a-independent precursor populations in developing zebrafish pancreas...
  2. pmc Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development
    Zhen Li
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Dev Biol 7:117. 2007
    ....
  3. doi Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
    Honghui Huang
    Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
    Development 135:3209-18. 2008
    ....
  4. pmc Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
    Mech Dev 128:525-35. 2012
    ..Altogether, these studies reveal that there is more than one way to form a liver, and provide molecular insights into the phenomenon of tissue plasticity...
  5. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  6. pmc Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development
    Morgane Poulain
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 138:3557-68. 2011
    ..Thus, tightly regulated spatiotemporal expression of wnt2bb, wnt2 and fzd5 is central to coordinating early liver, pancreas and swim bladder development from a multipotent foregut endoderm...
  7. doi APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
  8. pmc Bmp2 signaling regulates the hepatic versus pancreatic fate decision
    Won Suk Chung
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 15:738-48. 2008
    ..These data provide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate that their fate is regulated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b...
  9. ncbi Mesodermal Wnt2b signalling positively regulates liver specification
    Elke A Ober
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
    Nature 442:688-91. 2006
    ..In zebrafish, the onset of liver specification is marked by the localized endodermal expression of hhex and prox1 at 22 hours post fertilization...
  10. doi Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish
    Muhammad Farooq
    Department of Biological Sciences, National University of Singapore, 117543, Singapore
    Dev Biol 317:336-53. 2008
    ..These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development...
  11. ncbi Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors
    Osama A Elsalini
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Dev Biol 263:67-80. 2003
    During zebrafish development, the thyroid primordium initiates expression of molecular markers such as hhex and nk2.1a in the endoderm prior to pharynx formation...
  12. ncbi Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish
    W Liao
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California at San Francisco, San Francisco, CA 94143 0448, USA
    Development 127:4303-13. 2000
    ..Here we report that in zebrafish the homeobox gene hhex (previously called hex) is also expressed in endothelial and blood lineages from an early stage...
  13. pmc Cyp26 enzymes function in endoderm to regulate pancreatic field size
    Mary D Kinkel
    Department of Organismal Biology and Anatomy and Committee on Developmental Biology, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:7864-9. 2009
    ..Such feedback can maintain consistent levels of RA signaling, despite environmental fluctuations in RA concentration, thus ensuring a consistent size and location of the pancreatic field...
  14. ncbi A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene
    C Y Ho
    Department of Biochemistry and Biophysics University of California at San Francisco San Francisco, California, 94143 0448, USA
    Curr Biol 9:1131-4. 1999
    ..To analyze whether similar mechanisms operate in other vertebrates, we cloned the zebrafish homologue of Hex, a homeobox gene that is expressed asymmetrically in the mouse visceral endoderm [2]...
  15. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ..We found that the expression of hhex and prox1, the earliest liver markers in zebrafish, was severely reduced in the liver region when Bmp or Fgf ..
  16. ncbi Zebrafish hhex regulates liver development and digestive organ chirality
    K N Wallace
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genesis 30:141-3. 2001
  17. doi Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
    XuBo Niu
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
    Dev Biol 367:197-207. 2012
    ..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system...
  18. pmc Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb
    Joseph J Lancman
    Sanford Children s Health Research Center, Programs in Genetic Disease, Development and Aging, and Stem Cell and Regenerative Biology, Graduate School of Biomedical Sciences, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Development 140:2669-79. 2013
    ..Collectively, our findings provide a new model for HNF1B function, yield insight into pancreas and β-cell development, and suggest a new mechanism for hepatopancreatic specification...
  19. doi Zebrafish bcl2l is a survival factor in thyroid development
    Immacolata Porreca
    IRGS, BIOGEM, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy
    Dev Biol 366:142-52. 2012
    ..1a and hhex. Also, the bcl2l gene appears to control a caspase-3-dependent apoptotic mechanism during thyroid development...
  20. doi Perfluorooctane sulfonic acid exposure increases cadmium toxicity in early life stage of zebrafish, Danio rerio
    Suyoung Kim
    School of Public Health, Seoul National University, Seoul, Korea
    Environ Toxicol Chem 30:870-7. 2011
    ..hormone receptor-alpha [THRα], thyroid hormone receptor-beta [THRβ], hematopoietically expressed homeobox [hhex], and paired box gene 8 [pax8]) and decrease of throxine (T4) levels were observed in the PFOS preexposure group, ..
  21. pmc Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogensis in the zebrafish, Danio rerio
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e62470. 2013
    ..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
  22. doi Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish
    Liqin Yu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Environ Sci Technol 45:10652-9. 2011
    ..For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations...
  23. doi EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development
    Huiqiang Lu
    Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, Beibei, 400715 Chongqing, China
    Dev Cell 24:543-53. 2013
    ..Our results identify EpCAM as the key molecule and its functional mechanism to confer endodermal cells the competence to respond to the liver-inductive Wnt2bb signal...
  24. pmc Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas
    François Naye
    Unit of Molecular Biology and Genetic Engineering, GIGA Research, University of Liege, B 4000 Sart Tilman, Belgium, Germany
    Mol Biol Cell 23:945-54. 2012
    ..These mutants display ventral pancreas agenesis and ectopic masses of hepatocytes. Overall, these data highlight the dynamic role of BMP and FGF in the patterning of the hepatopancreatic region...
  25. doi Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays
    Guizhen Du
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China
    Chemosphere 91:1099-106. 2013
    ..Exposure of zebrafish embryo to PFOA resulted in higher expression of esr1, hhex and pax. PFOA is able to interfere with hormone receptor ER and TR...
  26. pmc Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation
    Shu Yu Wu
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Biol 10:e1001403. 2012
    ..Our study delineates a novel negative, Gsk3β-independent control mechanism of β-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation...
  27. pmc Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development
    Zahra Tehrani
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Development 138:631-40. 2011
    ..These results identify multiple sequential roles for Hh in pancreas development and highlight an unexpected antagonistic relationship between Hh and other signaling pathways to control pancreatic specification and differentiation...
  28. ncbi Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish
    Johannes Bischof
    Developmental Biology, Institute of Biology 1, University of Freiburg, Haupstrasse 1, D 79104 Freiburg, Germany
    Dev Biol 276:552-62. 2004
    ..the anterior endomesoderm in frogs (Xhex), the anterior visceral endoderm in mice, and the dorsal YSL in zebrafish (hhex). Here, we investigate the control of hhex expression in the YSL...
  29. pmc The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration
    Keith R Anderson
    Molecular Biology Program, University of Colorado Denver, Aurora, CO 80045, USA
    Development 138:3213-24. 2011
    ..Identification of a role for Tm4sf4 during endocrine differentiation provides insight into islet progenitor cell behaviors and potential targetable regenerative mechanisms...
  30. pmc Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis
    Christian Klein
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Development 138:1935-45. 2011
    ..We conclude that nav3a is required for directing endodermal organogenesis involving coordination of endodermal cell behavior...
  31. doi TSH receptor function is required for normal thyroid differentiation in zebrafish
    Robert Opitz
    Institute of Interdisciplinary Research in Molecular Human Biology, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Endocrinol 25:1579-99. 2011
    ..A comparison of our results with phenotypes observed in mouse models of defective TSHR and cAMP signaling highlights the value of zebrafish as a model to enhance the understanding of functional differentiation in the vertebrate thyroid...
  32. pmc liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish
    Changqing Chang
    College of Animal Sciences, Zhejiang University, Hangzhou, People s Republic of China
    PLoS ONE 6:e22910. 2011
    ..Finally, we proved that Leg1 is a secretory protein. This intrigued us to propose that Leg1 might act as a novel secreted regulator that is essential for liver and other digestive organ development in zebrafish...
  33. pmc A crucial interaction between embryonic red blood cell progenitors and paraxial mesoderm revealed in spadetail embryos
    Laurel A Rohde
    Department of Organismal Biology and Anatomy, University of Chicago, IL 60637 USA
    Dev Cell 7:251-62. 2004
    ..Importantly, our data identify a hematopoietic microenvironment that allows embryonic RBC production in the zebrafish...
  34. ncbi Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005
    ..Surprisingly, in cloche, lmo2 was not induced in response to scl over-expression. Taken together, these findings support distinct roles for scl in hematopoietic and endothelial development, downstream of hemangioblast development...
  35. ncbi Transcriptional regulation of hematopoietic stem cell development in zebrafish
    Nelson Hsia
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:1007-14. 2005
    ..Future studies using new technologies in the zebrafish model will enhance our understanding of the molecular networks regulating HSC pluripotency and differentiation...
  36. ncbi Liver specification: a new role for Wnts in liver development
    Zoe D Burke
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Biol 16:R688-90. 2006
    ..Secreted Wnt proteins control a diverse array of developmental decisions. A recent analysis of the zebrafish mutant prometheus points to a previously unknown role for Wnts during liver specification...
  37. pmc Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation
    Douglas C Weiser
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 21:1559-71. 2007
    ....
  38. ncbi Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Development 134:2871-9. 2007
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects...
  39. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
    ....
  40. pmc Organ-specific requirements for Hdac1 in liver and pancreas formation
    Emily S Noël
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Dev Biol 322:237-50. 2008
    ..These findings establish zebrafish as a tractable system to investigate chromatin remodelling factor functions in controlling gene expression programmes in vertebrate endodermal organogenesis...
  41. doi Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors
    Enid Yi Ni Lam
    Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand
    Blood 113:1241-9. 2009
    ..The ability to visualize and isolate fluorescently labeled HSCs should contribute to further elucidating the complex regulation of HSC development...
  42. pmc Alpha2 macroglobulin-like is essential for liver development in zebrafish
    Sung Kook Hong
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    PLoS ONE 3:e3736. 2008
    ....
  43. doi Hgf/c-met expression and functional analysis during zebrafish embryogenesis
    Andrew J Latimer
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Dyn 237:3904-15. 2008
    ..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish...
  44. pmc Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish
    Fei Qi
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing, China
    Hepatology 52:2158-66. 2010
    ..Because mmp23b/MMP23B is highly conserved, our findings in zebrafish warrant further investigation of its role in regulating liver development in mammals...
  45. doi T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis
    Ana Faro
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Zebrafish 6:59-68. 2009
    ..This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt signaling in the intestine during zebrafish organogenesis...
  46. doi Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish
    Chisako Nakada
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    J Exp Zool B Mol Dev Evol 312:827-40. 2009
    ..Furthermore, the roles reported for FOXE1 in mammalian thyroid development may have been acquired during evolution...
  47. pmc Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish
    Kristen Alexa
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e8261. 2009
    ..expression is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp. In addition, mutant embryos display a swollen pericardium and lack fin buds...
  48. doi The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males
    Sara Zucchi
    School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, CH 4132 Muttenz, Switzerland
    Toxicol Appl Pharmacol 250:137-46. 2011
    ..In eleuthero-embryos transcripts of vtg1, vtg3, esr1, esr2b, hsd17ß3, cyp19b cyp19a, hhex and pax8 were induced at 3000 μg/L BP-4, which points to a low estrogenic activity and interference with early ..
  49. doi Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways
    M X Chang
    State Key Laboratory of Freshwater Ecology and Biotechnology, and Laboratory of Fish Diseases, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province 430072, PR China
    Fish Shellfish Immunol 26:264-74. 2009
    ..When transiently over-expressed in HEK293T cells, zfPGRP-SC inhibited NF-kappaB activity with and without lipopolysacharide (LPS) stimulation...
  50. pmc Common genetic control of haemangioblast and cardiac development in zebrafish
    Tessa Peterkin
    Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK
    Development 136:1465-74. 2009
    ....

Research Grants1

  1. Role of cdx genes and RA in regionalizing the endoderm
    MARY KINKEL; Fiscal Year: 2007
    ..Finally, I will investigate the role of RA signaling in regulating Cdx genes utilizing loss-of-function approaches as well as treatment with exogenous RA. ..