her5

Summary

Gene Symbol: her5
Description: hairy-related 5
Alias: her-5, zgc:136537, hairy-related 5
Species: zebrafish
Products:     her5

Top Publications

  1. Diks S, Bink R, van de Water S, Joore J, van Rooijen C, Verbeek F, et al. The novel gene asb11: a regulator of the size of the neural progenitor compartment. J Cell Biol. 2006;174:581-92 pubmed
    ..We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors. ..
  2. Reifers F, Böhli H, Walsh E, Crossley P, Stainier D, Brand M. Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development. 1998;125:2381-95 pubmed
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others. ..
  3. Ninkovic J, Tallafuss A, Leucht C, Topczewski J, Tannhäuser B, Solnica Krezel L, et al. Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development. 2005;132:75-88 pubmed
    ..Recently, we implicated the Hairy/E(spl) transcription factor Her5 in the formation of the medial (most basal) part of the IZ (MIZ) in zebrafish; the molecular bases for lateral IZ (..
  4. Geling A, Plessy C, Rastegar S, Strahle U, Bally Cuif L. Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary. Development. 2004;131:1993-2006 pubmed
    ..We report here that the bHLH factor Her5 acts as a prepattern gene to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish ..
  5. Tallafuss A, Bally Cuif L. Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance. Development. 2003;130:4307-23 pubmed
    ..in zebrafish to construct lines where egfp transcription is driven by the complete set of regulatory elements of her5, the first known gene expressed in the MH area...
  6. Lun K, Brand M. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development. 1998;125:3049-62 pubmed
    ..In contrast, onset of wnt1, fgf8 and her5 expression occurs normally in the null mutants, but is eliminated later on...
  7. Gajewski M, Elmasri H, Girschick M, Sieger D, Winkler C. Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Dev Genes Evol. 2006;216:315-32 pubmed publisher
    ..In contrast to Dr-her5, the medaka orthologue appears to play a role in somitogenesis because it is expressed in the presomitic mesoderm (..
  8. Miyake A, Nakayama Y, Konishi M, Itoh N. Fgf19 regulated by Hh signaling is required for zebrafish forebrain development. Dev Biol. 2005;288:259-75 pubmed
    ..The present findings indicate that Fgf19 signaling is crucial for forebrain development by interacting with Hh and provide new insights into the roles of Fgf signaling in brain development. ..
  9. Hans S, Scheer N, Riedl I, v Weizsäcker E, Blader P, Campos Ortega J. her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development. 2004;131:2957-69 pubmed
    ..Moreover, Her3 represses its own transcription as well. Surprisingly, and in sharp contrast to other members of the E(spl) gene family, transcription of her3 is repressed rather than activated by Notch signalling. ..

More Information

Publications57

  1. Geling A, Itoh M, Tallafuss A, Chapouton P, Tannhäuser B, Kuwada J, et al. bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary. Development. 2003;130:1591-604 pubmed
    ..We further show that expression of the zebrafish bHLH Hairy/E(spl)-related factor Her5 prefigures and then precisely delineates the IZ throughout embryonic development...
  2. Chapouton P, Adolf B, Leucht C, Tannhäuser B, Ryu S, Driever W, et al. her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain. Development. 2006;133:4293-303 pubmed
    ..cell populations in this system, we used an embryonic neural stem cell marker, the E(spl) bHLH transcription factor Her5. We demonstrate that her5 expression is not restricted to embryonic neural progenitors, but also defines in the ..
  3. Gajewski M, Voolstra C. Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish. BMC Genomics. 2002;3:21 pubmed
    ..Comparison to the human genome suggests a selective duplication of h/E(spl) genes in pufferfish or loss of members of these genes during evolution to the human lineage. ..
  4. Ninkovic J, Stigloher C, Lillesaar C, Bally Cuif L. Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity. Development. 2008;135:3137-48 pubmed publisher
    ..This role is performed in zebrafish by the E(Spl) factors Her5 and Her11, but the molecular cascades cooperating with Her5/11, and those accounting for their reduced effect in ..
  5. Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells. ..
  6. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling. ..
  7. Larson T, Gordon T, Lau H, Parichy D. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Dev Biol. 2010;346:296-309 pubmed publisher
    ..This study identifies the puma mutant as a valuable model for studying microtubule-dependent events of myelination, as well as strategies for remyelination in the adult. ..
  8. Zhou M, Yan J, Ma Z, Zhou Y, Abbood N, Liu J, et al. Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events. PLoS ONE. 2012;7:e40649 pubmed publisher
    ..This study shows a model of gene family analysis with gene structure evolution and duplication. ..
  9. Labalette C, Bouchoucha Y, Wassef M, Gongal P, Le Men J, Becker T, et al. Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4. Development. 2011;138:317-26 pubmed publisher
    ..In this mode of patterning, precision and robustness can be achieved by the introduction of a negative-feedback loop, which, in the hindbrain, is mediated by Spry4. ..
  10. Bielen H, Houart C. BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis. Dev Cell. 2012;23:812-22 pubmed publisher
  11. Shinya M, Eschbach C, Clark M, Lehrach H, Furutani Seiki M. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev. 2000;98:3-17 pubmed
    ..The nodal gene squint is also required for the maintenance of dkk1 expression. Among the mutually dependent target genes of the pre-MBT Wnt signaling, dkk1 plays an important role in patterning the anterior head of zebrafish. ..
  12. Foucher I, Mione M, Simeone A, Acampora D, Bally Cuif L, Houart C. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 2006;133:1891-900 pubmed
    ..This maintenance is enough to allow cerebellar differentiation. ..
  13. Sartori da Silva M, Tee J, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, et al. Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo. PLoS ONE. 2010;5:e14023 pubmed publisher
  14. Dworkin S, Darido C, Georgy S, Wilanowski T, Srivastava S, Ellett F, et al. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development. 2012;139:525-36 pubmed publisher
    ..Collectively, these data show that MHB maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets. ..
  15. Shin C, Chung W, Hong S, Ober E, Verkade H, Field H, et al. Multiple roles for Med12 in vertebrate endoderm development. Dev Biol. 2008;317:467-79 pubmed publisher
    ..defects are partially due to a reduction in endodermal expression of the hairy/enhancer of split-related gene, her5, at mid to late gastrulation stages. Using the Tg(0...
  16. Chapouton P, Webb K, Stigloher C, Alunni A, Adolf B, Hesl B, et al. Expression of hairy/enhancer of split genes in neural progenitors and neurogenesis domains of the adult zebrafish brain. J Comp Neurol. 2011;519:1748-69 pubmed publisher
  17. Galant S, Furlan G, Coolen M, Dirian L, Foucher I, Bally Cuif L. Embryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain. Dev Biol. 2016;420:120-135 pubmed publisher
    ..We reveal that a subpopulation of her5-positive NE cells of the posterior midbrain layer stands at the top of a neurogenic hierarchy involving, in order, ..
  18. Vaccari E, Deflorian G, Bernardi E, Pauls S, Tiso N, Bortolussi M, et al. prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Dev Biol. 2010;343:94-103 pubmed publisher
    ..As the paralogue gene prep1.1 is more important in hindbrain patterning and neural crest chondrogenesis, we provide evidence of a functional specialization of prep genes in zebrafish head segmentation and morphogenesis...
  19. Mei J, Zhang Q, Li Z, Lin S, Gui J. C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol. 2008;319:273-84 pubmed publisher
  20. Burgess S, Reim G, Chen W, Hopkins N, Brand M. The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Development. 2002;129:905-16 pubmed
  21. Stigloher C, Ninkovic J, Laplante M, Geling A, Tannhäuser B, Topp S, et al. Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3. Development. 2006;133:2925-35 pubmed
    ..These results suggest that the process segregating the telencephalic and eye fields is isolated from diencephalic patterning, and is mediated by Rx3. ..
  22. Tallafuss A, Wilm T, Crozatier M, Pfeffer P, Wassef M, Bally Cuif L. The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development. Development. 2001;128:4021-34 pubmed
    ..epiblast including the presumptive MHD, and precedes in this area the expression of other MHD markers such as her5, pax2.1 and wnt1...
  23. Miyake A, Itoh N. Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development. Biol Open. 2013;2:515-24 pubmed publisher
    ..Furthermore, fgf22 partially rescued the fgf3/fgf8 double morphant phenotype. The present results indicate Fgf22 to be involved in midbrain development downstream of Fgf3 and Fgf8 in the MHB but not of Hh in the floor plate. ..
  24. Caron A, Xu X, Lin X. Wnt/?-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012;139:514-24 pubmed publisher
    ..Moreover, our results also prompt a hypothesis that certain developmental effects of the Wnt/?-catenin pathway are due to the activation of Foxj1 and cilia formation...
  25. Trinh L, Meyer D, Stainier D. The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish. Development. 2003;130:4989-98 pubmed
  26. Choe C, Collazo A, Trinh L, Pan L, Moens C, Crump J. Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013;24:296-309 pubmed publisher
    ..We propose that this dynamic control of epithelial morphology by Wnt signaling may be a common theme for the budding of organ anlagen from the endoderm. ..
  27. Webb K, Coolen M, Gloeckner C, Stigloher C, Bahn B, Topp S, et al. The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish. BMC Dev Biol. 2011;11:27 pubmed publisher
    ..We used a yeast two-hybrid screen with Her5 as bait and recovered a novel zebrafish Hairy/E(spl) factor--Her8a...
  28. Bouleau A, Desvignes T, Traverso J, Nguyen T, Chesnel F, Fauvel C, et al. Maternally inherited npm2 mRNA is crucial for egg developmental competence in zebrafish. Biol Reprod. 2014;91:43 pubmed publisher
    ..Finally, our results suggest that npm2 maternal mRNA is an important molecular factor of egg quality in fish and possibly in all vertebrates. ..
  29. Wei Y, Ma D, Gao Y, Zhang C, Wang L, Liu F. Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood. 2014;124:1578-85 pubmed publisher
    ..Thus, our findings identify a novel regulatory mechanism for Ncor2 through Fos-Vegfd-Notch signaling cascade during HSC development in zebrafish embryos. ..
  30. Dias T, Yang Y, Ogai K, Becker T, Becker C. Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish. J Neurosci. 2012;32:3245-52 pubmed publisher
    ..This demonstrates that Notch is a negative signal for regenerative neurogenesis, and, importantly, that spinal motor neuron regeneration can be augmented in an adult vertebrate by inhibiting Notch signaling. ..
  31. Mathieu J, Griffin K, Herbomel P, Dickmeis T, Strahle U, Kimelman D, et al. Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Development. 2004;131:629-41 pubmed
    ..Together, these results demonstrate synergy between oep and fgf8 that operates with regional differences and is involved in the induction, maintenance, movement and survival of mesodermal cell populations. ..
  32. Stuckenholz C, Lu L, Thakur P, Choi T, Shin D, Bahary N. Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e62470 pubmed publisher
    ..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
  33. Shima T, Znosko W, Tsang M. The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo). Dev Dyn. 2009;238:899-907 pubmed publisher
    ..Based on these findings, we propose that the mgo mutation genetically interacts with pax2a required for the initiation of MHB formation. ..
  34. zhan G, Sezgin E, Wehner D, Pfister A, K hl S, Kagermeier Schenk B, et al. Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013;26:331-45 pubmed publisher
    ..Thus, Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling...
  35. Dyer C, Blanc E, Hanisch A, Roehl H, Otto G, Yu T, et al. A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. Development. 2014;141:63-72 pubmed publisher
    ..along the anterior-posterior axis of the dorsal midbrain and directs spatially dynamic expression of the Hairy gene her5. As FGF activity diminishes during development, Her5 is lost and differentiation of neuronal progenitors occurs in ..
  36. Tiso N, Filippi A, Pauls S, Bortolussi M, Argenton F. BMP signalling regulates anteroposterior endoderm patterning in zebrafish. Mech Dev. 2002;118:29-37 pubmed
    ..cells expressing cas and sox17 in swirl and chordino gastrulae, but affect dramatically the expression pattern of her5, a regulator of endoderm anteroposterior patterning in zebrafish...
  37. Tallafuss A, Adolf B, Bally Cuif L. Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plate. Dev Dyn. 2003;227:524-35 pubmed
    ..Together, our results suggest that a combination of patterning-related and -unrelated mechanisms specifically controls the size of individual early neuronal clusters within the anterior neural plate. ..
  38. Yin W, Liu D, Liu N, Xu L, Li S, Lin S, et al. SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1. Cell Regen (Lond). 2012;1:4 pubmed publisher
  39. Dyer C, Blanc E, Stanley R, Knight R. Dissecting the role of Wnt signaling and its interactions with FGF signaling during midbrain neurogenesis. Neurogenesis (Austin). 2015;2:e1057313 pubmed publisher
    ..This highlights the complex nature of the interactions between FGF and Wnt/ bcat and reveals that they act at multiple levels to control each others activity in the midbrain. ..
  40. Kopinke D, Sasine J, Swift J, Stephens W, Piotrowski T. Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification. Dev Dyn. 2006;235:2695-709 pubmed
    ..These results demonstrate that the developmental processes underlying pharyngeal arch defects differ depending on when RA signaling is disturbed during development...
  41. Leucht C, Stigloher C, Wizenmann A, Klafke R, Folchert A, Bally Cuif L. MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary. Nat Neurosci. 2008;11:641-8 pubmed publisher
    ..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis...
  42. Hwang J, Kim H, Seok J, Kim J, Koun S, Park S, et al. Transcriptome analysis of the zebrafish mind bomb mutant. Mol Genet Genomics. 2009;281:77-85 pubmed publisher
    ..Interestingly, it was suggested that the mib ( ta52b ) mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway. ..
  43. Artinger K, Chitnis A, Mercola M, Driever W. Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons. Development. 1999;126:3969-79 pubmed
    ..We discuss the implications of these findings for the possibility that RB sensory neurons and neural crest cells share a common evolutionary origin. ..
  44. Witzel H, Jungblut B, Choe C, Crump J, Braun T, Dobreva G. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell. 2012;23:58-70 pubmed publisher
    ..We conclude that Ajuba plays a central role in regulating the SHF during heart development by linking RA signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells. ..
  45. Coolen M, Thieffry D, Drivenes Ø, Becker T, Bally Cuif L. miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors. Dev Cell. 2012;22:1052-64 pubmed publisher
  46. Das A, Crump J. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002710 pubmed publisher
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  47. Chung P, Lin W, Scotting P, Hsieh F, Wu H, Cheng Y. Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis. PLoS ONE. 2011;6:e19394 pubmed publisher
  48. Znosko W, Yu S, Thomas K, Molina G, Li C, Tsang W, et al. Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol. 2010;342:11-25 pubmed publisher
    ..We further demonstrated the interaction of Pea3 ETS factors with the Dusp6 promoter both in vitro and in vivo. These results revealed the requirement of ETS factors in transducing FGF signals in developmental processes. ..