her1

Summary

Gene Symbol: her1
Description: hairy-related 1
Alias: HER-1, id:ibd5086, transcription factor HES-7, Hes7, etID309753.5
Species: zebrafish

Top Publications

  1. Echeverri K, Oates A. Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism. Dev Biol. 2007;301:388-403 pubmed
  2. Akanuma T, Koshida S, Kawamura A, Kishimoto Y, Takada S. Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation. EMBO Rep. 2007;8:858-63 pubmed
    ..rtf1 is required for correct RNA levels of the Notch-regulated genes her1, her7 and deltaC, and also for Notch-induced her1 expression in the presomitic mesoderm...
  3. Amacher S, Draper B, Summers B, Kimmel C. The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. Development. 2002;129:3311-23 pubmed
  4. van Eeden F, Holley S, Haffter P, Nusslein Volhard C. Zebrafish segmentation and pair-rule patterning. Dev Genet. 1998;23:65-76 pubmed
    ..to characterize the defects caused by the fss-type mutations, we examined their effects on the expression of her1, a zebrafish homologue of the Drosophila pair-rule gene hairy...
  5. Diks S, Bink R, van de Water S, Joore J, van Rooijen C, Verbeek F, et al. The novel gene asb11: a regulator of the size of the neural progenitor compartment. J Cell Biol. 2006;174:581-92 pubmed
    ..We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors. ..
  6. Takke C, Dornseifer P, v Weizsäcker E, Campos Ortega J. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. Development. 1999;126:1811-21 pubmed
    ..These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis. ..
  7. Sawada A, Fritz A, Jiang Y, Yamamoto A, Yamasu K, Kuroiwa A, et al. Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development. 2000;127:1691-702 pubmed
    ..This suggests that these genes are downstream targets of fss at the segmentation stage. Comparison with her1 expression (Müller, M., von Weizsäcker, E. and Campos-Ortega, J. A...
  8. Gajewski M, Elmasri H, Girschick M, Sieger D, Winkler C. Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Dev Genes Evol. 2006;216:315-32 pubmed publisher
    ..For the paralogues Dr-her1 and Dr-her11, only one copy exists in the medaka (Ol-her1/11), which combines the expression patterns found for ..
  9. Stulberg M, Lin A, Zhao H, Holley S. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Dev Biol. 2012;369:298-307 pubmed publisher

More Information

Publications74

  1. Jülich D, Hwee Lim C, Round J, Nicolaije C, Schroeder J, Davies A, et al. beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation. Dev Biol. 2005;286:391-404 pubmed
    ..Mutations in aei/deltaD and bea/deltaC differ in the way they disrupt the oscillating expression of her1 and deltaC...
  2. Ninkovic J, Tallafuss A, Leucht C, Topczewski J, Tannhäuser B, Solnica Krezel L, et al. Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development. 2005;132:75-88 pubmed
    ..We propose a molecular mechanism for this process where the global 'Him+Her5' activity inhibits ngn1 expression in a dose-dependent manner and through different sensitivity thresholds along the medio-lateral axis of the neural plate. ..
  3. Holley S, Jülich D, Rauch G, Geisler R, NUSSLEIN VOLHARD C. her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development. 2002;129:1175-83 pubmed
    ..In the zebrafish, oscillations in the expression of a hairy-related transcription factor, her1 and the notch ligand deltaC precede somite formation...
  4. Oates A, Mueller C, Ho R. Cooperative function of deltaC and her7 in anterior segment formation. Dev Biol. 2005;280:133-49 pubmed
    ..A combined loss of the cyclic Her genes her1 and her7 disrupts segmentation of both anterior and posterior paraxial mesoderm, indicating that her genes function ..
  5. Muller M, v Weizsäcker E, Campos Ortega J. Expression domains of a zebrafish homologue of the Drosophila pair-rule gene hairy correspond to primordia of alternating somites. Development. 1996;122:2071-8 pubmed
    b>her1 is a zebrafish cDNA encoding a bHLH protein with all features characteristic of members of the Drosophila HAIRY-E(SPL) family...
  6. Kawamura A, Koshida S, Hijikata H, Ohbayashi A, Kondoh H, Takada S. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Dev Cell. 2005;9:735-44 pubmed
    ..Thus, ripply1 plays dual roles in the transition from the PSM to somites: termination of the segmentation program in the PSM and maintenance of the rostrocaudal polarity. ..
  7. Ozbudak E, Lewis J. Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries. PLoS Genet. 2008;4:e15 pubmed publisher
    ..Using a GFP reporter for the oscillator gene her1, we measure the influence of Notch signalling on her1 expression and show by mathematical modelling that this is ..
  8. Giudicelli F, Ozbudak E, Wright G, Lewis J. Setting the tempo in development: an investigation of the zebrafish somite clock mechanism. PLoS Biol. 2007;5:e150 pubmed
    ..at least, may be generated by a delayed negative feedback loop in which the products of two Notch target genes, her1 and her7, directly inhibit their own transcription, as well as that of the gene for the Notch ligand DeltaC; Notch ..
  9. Brend T, Holley S. Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock. Dev Dyn. 2009;238:2745-59 pubmed publisher
    ..we present a detailed analysis of cis-regulatory elements that control oscillating expression of the zebrafish her1 gene in the anterior presomitic mesoderm...
  10. Akiyama R, Masuda M, Tsuge S, Bessho Y, Matsui T. An anterior limit of FGF/Erk signal activity marks the earliest future somite boundary in zebrafish. Development. 2014;141:1104-9 pubmed publisher
  11. Sieger D, Tautz D, Gajewski M. her11 is involved in the somitogenesis clock in zebrafish. Dev Genes Evol. 2004;214:393-406 pubmed
    ..We describe here the functional analysis of one of these genes, which we have named her11. her11 is a paralogue of her1 and, similar to her1, is arranged in a head to head fashion with another her gene, namely the previously described ..
  12. Gajewski M, Sieger D, Alt B, Leve C, Hans S, Wolff C, et al. Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development. 2003;130:4269-78 pubmed
    ..into how oscillatory expression is achieved in the zebrafish Danio rerio, we have analysed the regulation of her1 and her7, two bHLH genes that are co-expressed in the PSM...
  13. Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani Seiki M, Kondoh H, et al. Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell. 2005;8:587-98 pubmed
  14. Kawamura A, Koshida S, Hijikata H, Sakaguchi T, Kondoh H, Takada S. Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes Dev. 2005;19:1156-61 pubmed
    ..her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13...
  15. Stickney H, Barresi M, Devoto S. Somite development in zebrafish. Dev Dyn. 2000;219:287-303 pubmed
    ..We show directly, for the first time, that muscle cell and sclerotome migrations occur at the same time. We end with a look at the many questions about somitogenesis that are still unanswered. ..
  16. Schroter C, Ares S, Morelli L, Isakova A, Hens K, Soroldoni D, et al. Topology and dynamics of the zebrafish segmentation clock core circuit. PLoS Biol. 2012;10:e1001364 pubmed publisher
    ..We show that the core pace-making circuit consists of two distinct negative feedback loops, one with Her1 homodimers and the other with Her7:Hes6 heterodimers, operating in parallel...
  17. Takke C, Campos Ortega J. her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Development. 1999;126:3005-14 pubmed
    ..truncated variant of deltaD [deltaD(Pst)], as well as transcripts of deltaC and deltaD, the hairy-E(spl) homologues her1 and her4, and groucho2 were tested for their effects on somite formation, myogenesis and on the pattern of ..
  18. Sieger D, Ackermann B, Winkler C, Tautz D, Gajewski M. her1 and her13.2 are jointly required for somitic border specification along the entire axis of the fish embryo. Dev Biol. 2006;293:242-51 pubmed
    ..2 in conjunction with her genes that are under Delta-Notch control. We show that joint inactivation of her1 and her13.2 leads to a complete loss of all somitic borders, including the most anterior ones...
  19. Riedel Kruse I, Müller C, Oates A. Synchrony dynamics during initiation, failure, and rescue of the segmentation clock. Science. 2007;317:1911-5 pubmed
  20. Jülich D, Geisler R, Holley S. Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Dev Cell. 2005;8:575-86 pubmed
    ..Our data suggest that notch- and integrinalpha5-dependent cell polarization and Fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis. ..
  21. Henry C, Urban M, Dill K, Merlie J, Page M, Kimmel C, et al. Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries. Development. 2002;129:3693-704 pubmed
    ..We have isolated a zebrafish deficiency, b567, that deletes two linked her genes, her1 and her7. Homozygous b567 mutants have defective somites along the entire embryonic axis...
  22. Choorapoikayil S, Willems B, Ströhle P, Gajewski M. Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module. PLoS ONE. 2012;7:e39073 pubmed publisher
    ..Due to genome duplication events, the zebrafish genome, possesses two gene copies of the mouse Hes7 homologue: her1 and her7...
  23. Mara A, Schroeder J, Chalouni C, Holley S. Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC. Nat Cell Biol. 2007;9:523-30 pubmed
    ..by a segmentation clock that generates oscillations in expression of several Notch pathway genes, including her1, her7 and deltaC...
  24. Lewis J. Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol. 2003;13:1398-408 pubmed
    ..In zebrafish, two linked oscillating genes, her1 and her7, coding for inhibitory gene regulatory proteins, are especially implicated in genesis of the oscillations, ..
  25. Trofka A, Schwendinger Schreck J, Brend T, Pontius W, Emonet T, Holley S. The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development. 2012;139:940-7 pubmed publisher
    ..Dimerization is specific, with Hes6 serving as the hub of the network. Her1 binds DNA only as a homodimer but will also dimerize with Hes6...
  26. Bajard L, Morelli L, Ares S, Pécréaux J, Jülicher F, Oates A. Wnt-regulated dynamics of positional information in zebrafish somitogenesis. Development. 2014;141:1381-91 pubmed publisher
    ..The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information. ..
  27. Cinquin O. Repressor dimerization in the zebrafish somitogenesis clock. PLoS Comput Biol. 2007;3:e32 pubmed
    ..These networks can reproduce knockdown phenotypes, and strongly suggest the existence of a Her1-Her7 heterodimer, so far untested experimentally...
  28. Gajewski M, Voolstra C. Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish. BMC Genomics. 2002;3:21 pubmed
    ..This motif was also discovered in the upstream sequences of the her1 gene in the examined fish species. Here, the Su(h) sites are separated by longer intervening sequences...
  29. Shimizu T, Bae Y, Muraoka O, Hibi M. Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol. 2005;279:125-41 pubmed
    ..These data indicate that the cdx genes mediate Wnt signaling and play essential roles in the morphogenesis of the posterior body in zebrafish. ..
  30. Horikawa K, Ishimatsu K, Yoshimoto E, Kondo S, Takeda H. Noise-resistant and synchronized oscillation of the segmentation clock. Nature. 2006;441:719-23 pubmed
    ..The intercellular coupling was found to have a crucial role in minimizing the effects of this noise to maintain coherent oscillation. ..
  31. Kawahara A, Che Y, Hanaoka R, Takeda H, Dawid I. Zebrafish GADD45beta genes are involved in somite segmentation. Proc Natl Acad Sci U S A. 2005;102:361-6 pubmed
    ..antisense morpholino oligonucleotides caused a broad expansion of mesp-a in the PSM, and both cyclic expression of her1 and segmented expression of MyoD were disorganized...
  32. Schroter C, Oates A. Segment number and axial identity in a segmentation clock period mutant. Curr Biol. 2010;20:1254-8 pubmed publisher
  33. Winkler C, Elmasri H, Klamt B, Volff J, Gessler M. Characterization of hey bHLH genes in teleost fish. Dev Genes Evol. 2003;213:541-53 pubmed
    ..Overexpression of dlD on the other hand results in the ectopic expression of hey1 in the axial mesoderm. Hence, hey1 represents a target of Delta-Notch signaling dynamically expressed during somite formation in zebrafish. ..
  34. Delaune E, Francois P, Shih N, Amacher S. Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics. Dev Cell. 2012;23:995-1005 pubmed publisher
  35. Shankaran S, Sieger D, Schroter C, Czepe C, Pauly M, Laplante M, et al. Completing the set of h/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock. Dev Biol. 2007;304:615-32 pubmed
    ..expression in the PSM is regulated by Delta-Notch signaling in a complex manner, and is dependent on her7, but not her1 function...
  36. Sieger D, Tautz D, Gajewski M. The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Mech Dev. 2003;120:1083-94 pubmed
    ..of Su(H) in the somitogenesis process and its influence on the expression of notch pathway genes, in particular her1, her7, deltaC and deltaD...
  37. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  38. Machingo Q, Fritz A, Shur B. A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish. Dev Biol. 2006;297:471-82 pubmed
  39. Lawton A, Nandi A, Stulberg M, Dray N, Sneddon M, Pontius W, et al. Regulated tissue fluidity steers zebrafish body elongation. Development. 2013;140:573-82 pubmed publisher
    ..Modeling and additional data analyses suggest that the balance between the coherence and rate of cell flow determines whether body elongation is linear or whether congestion forms within the flow and the body axis becomes contorted. ..
  40. Schwendinger Schreck J, Kang Y, Holley S. Modeling the zebrafish segmentation clock's gene regulatory network constrained by expression data suggests evolutionary transitions between oscillating and nonoscillating transcription. Genetics. 2014;197:725-38 pubmed publisher
  41. Bouldin C, Manning A, Peng Y, Farr G, Hung K, Dong A, et al. Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development. 2015;142:2499-507 pubmed publisher
  42. Mazzitello K, Arizmendi C, Hentschel H. Converting genetic network oscillations into somite spatial patterns. Phys Rev E Stat Nonlin Soft Matter Phys. 2008;78:021906 pubmed
    ..We also show that the model can mimic the anomalies formed when progression of the determination wave front is perturbed and make an experimental prediction that can be used to test the model. ..
  43. Li J, Yue Y, Dong X, Jia W, Li K, Liang D, et al. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. J Biol Chem. 2015;290:10216-28 pubmed publisher
    ..Taken together, our results demonstrate that foxc1a plays an essential role in early somitogenesis by controlling Fgf and Notch signaling through restricting the expression of aldh1a2 in paraxial mesoderm directly. ..
  44. Hans S, Campos Ortega J. On the organisation of the regulatory region of the zebrafish deltaD gene. Development. 2002;129:4773-84 pubmed
    ..Transcriptional control of deltaD by proneural proteins therefore represents a molecular target for the regulatory feedback loop mediated by the Notch pathway in lateral inhibition. ..
  45. Jahangiri L, Nelson A, Wardle F. A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites. Dev Biol. 2012;371:110-20 pubmed publisher
    ..This CRM is bound by both Ntla and Tbx16 at a cluster of T-box binding sites, which are required in combination for activation of the CRM. ..
  46. Retnoaji B, Akiyama R, Matta T, Bessho Y, Matsui T. Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference. Development. 2014;141:158-65 pubmed publisher
    ..The AP difference is attributable to spatiotemporal inhibition of the clock gene her1 via retinoic acid (RA) regulation of the transcriptional repressor ripply1...
  47. Durbin L, Sordino P, Barrios A, Gering M, Thisse C, Thisse B, et al. Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development. 2000;127:1703-13 pubmed
  48. Della Noce I, Carra S, Brusegan C, Critelli R, Frassine A, De Lorenzo C, et al. The Coiled-Coil Domain Containing 80 (ccdc80) gene regulates gadd45β2 expression in the developing somites of zebrafish as a new player of the hedgehog pathway. J Cell Physiol. 2015;230:821-30 pubmed publisher
    ..In this work we investigated the functional effects of ccdc80-loss-of-function during embryonic development and verified its interaction with gadd45β2 in somitogenesis. ..
  49. Begemann G, Schilling T, Rauch G, Geisler R, Ingham P. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development. 2001;128:3081-94 pubmed
  50. Wanglar C, Takahashi J, Yabe T, Takada S. Tbx protein level critical for clock-mediated somite positioning is regulated through interaction between Tbx and Ripply. PLoS ONE. 2014;9:e107928 pubmed publisher
  51. Ay A, Holland J, Sperlea A, Devakanmalai G, Knierer S, Sangervasi S, et al. Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves. Development. 2014;141:4158-67 pubmed publisher
    ..We validated this prediction by measuring an increased time delay of oscillatory Her1 protein production along the unsegmented tissue...
  52. Sawamiphak S, Kontarakis Z, Filosa A, Reischauer S, Stainier D. Transient cardiomyocyte fusion regulates cardiac development in zebrafish. Nat Commun. 2017;8:1525 pubmed publisher
    ..Together, our findings uncover the previously unrecognized process of transient cardiomyocyte fusion and identify its potential role in cardiac development and function. ..
  53. Dias T, Yang Y, Ogai K, Becker T, Becker C. Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish. J Neurosci. 2012;32:3245-52 pubmed publisher
    ..This demonstrates that Notch is a negative signal for regenerative neurogenesis, and, importantly, that spinal motor neuron regeneration can be augmented in an adult vertebrate by inhibiting Notch signaling. ..
  54. Saude L, Lourenço R, Gonçalves A, Palmeirim I. terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock. Nat Cell Biol. 2005;7:918-20 pubmed
    ..Here, we show that terra is an early left-sided expressed gene that links left-right patterning with bilateral synchronization of the segmentation clock. ..
  55. Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley S. Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Curr Biol. 2013;23:1335-41 pubmed publisher
    ..Tissue-specific transgenic rescue experiments suggest that the FN matrix on the surface of the paraxial mesoderm is required for body elongation via its role in defining tissue mechanics and intertissue adhesion. ..
  56. Durbin L, Brennan C, Shiomi K, Cooke J, Barrios A, Shanmugalingam S, et al. Eph signaling is required for segmentation and differentiation of the somites. Genes Dev. 1998;12:3096-109 pubmed
    ..Disruption of Eph family signaling delays the normal down-regulation of her1 and Delta D expression in the anterior presomitic mesoderm and disrupts myogenic differentiation...
  57. Soza Ried C, zt rk E, Ish Horowicz D, Lewis J. Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock. Development. 2014;141:1780-8 pubmed publisher
    ..The induced synchrony is manifest both morphologically and at the level of the oscillations of her1, a core component of the intracellular oscillator...
  58. Lee H, Tseng W, Lo F, Liu T, Tsai H. FoxD5 mediates anterior-posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis. Dev Biol. 2009;336:232-45 pubmed publisher
    ..An Fgf-FoxD5-Mesps signaling network is therefore proposed. ..
  59. Kok F, Oster E, Mentzer L, Hsieh J, Henry C, Sirotkin H. The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesis. Dev Biol. 2007;307:214-26 pubmed
    ..However, additional Spt6 mutant phenotypes are likely caused by vital functions of Spt6 in other pathways. ..
  60. Lin C, Lee H, Chen H, Hsieh C, Tsai H. Normal function of Myf5 during gastrulation is required for pharyngeal arch cartilage development in zebrafish embryos. Zebrafish. 2013;10:486-99 pubmed publisher
    ..Together, the loss of Myf5 function results in a cascade effect that begins with abnormal formation of the dorsal organizer during gastrulation, causing, in turn, defects in the CNC and cranial cartilage of myf5-knockdown embryos. ..
  61. Kok F, Shepherd I, Sirotkin H. Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis. Dev Dyn. 2010;239:548-58 pubmed publisher
    ..cycling gene expression occurs in the developing somites in ChCh and Sip1a compromised embryos, but expression of her1 and her7 is maintained in formed somites...
  62. Wright D, Ferjentsik Z, Chong S, Qiu X, Yun Jin J, Malapert P, et al. Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate. Dev Dyn. 2009;238:3043-3055 pubmed publisher
    ..Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes. ..
  63. Fongang B, Kudlicki A. Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. PLoS ONE. 2016;11:e0155802 pubmed publisher
    ..Our research lays the groundwork for further studies that will probe the evolution of the regulatory mechanism of segmentation across all vertebrates. ..
  64. Chen J, Jette C, Kanki J, Aster J, Look A, Griffin J. NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia. 2007;21:462-71 pubmed
    ..The ability of this model to detect a strong interaction between NOTCH1 and bcl2 suggests that genetic modifier screens have a high likelihood of revealing other genes that can cooperate with NOTCH1 to induce T-ALL. ..
  65. Lackner S, Schwendinger Schreck J, Jülich D, Holley S. Segmental assembly of fibronectin matrix requires rap1b and integrin ?5. Dev Dyn. 2013;242:122-31 pubmed publisher
    ..Somite patterning appears unaffected, as her1 oscillations are maintained in single and double morphants/mutants, but somite polarity is gradually lost in itg?5(-..