Gene Symbol: hdc
Description: histidine decarboxylase
Alias: histidine decarboxylase
Species: zebrafish

Top Publications

  1. Eriksson K, Peitsaro N, Karlstedt K, Kaslin J, Panula P. Development of the histaminergic neurons and expression of histidine decarboxylase mRNA in the zebrafish brain in the absence of all peripheral histaminergic systems. Eur J Neurosci. 1998;10:3799-812 pubmed
    ..Furthermore, the gene for histidine decarboxylase was partially cloned and its expression mapped with in situ hybridization...
  2. Pavlidis M, Sundvik M, Chen Y, Panula P. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behav Brain Res. 2011;225:529-37 pubmed publisher
    ..dopamine ?-hydroxylase, DBH; catechol-O-methyl transferase, COMT), in the biosynthesis of histamine (histidine decarboxylase, HDC) and in the general stress response (galanin, GAL; hypocretin/orexin, Hcrt) was examined...
  3. Sundvik M, Kudo H, Toivonen P, Rozov S, Chen Y, Panula P. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB J. 2011;25:4338-47 pubmed publisher
    ..Translation inhibition of histidine decarboxylase (hdc) with morpholino oligonucleotides (MOs) led to a behaviorally measurable decline in light-associated ..
  4. Sundvik M, Chen Y, Panula P. Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio. J Neurosci. 2013;33:1589-97 pubmed publisher
    ..The new histaminergic neurons in aging zebrafish brain may arise as a result of phenotypic plasticity or represent newly differentiated stem cells...
  5. Sallinen V, Kolehmainen J, Priyadarshini M, Toleikyte G, Chen Y, Panula P. Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish. Neurobiol Dis. 2010;40:93-101 pubmed publisher
    ..Distinct groups of dopaminergic neurons are thus sensitive to loss of Pink1. Sensitization of the pink1 morphant fish to MPTP toxicity suggests that genetic factors play a role in toxin-induced Parkinson's disease...
  6. Puttonen H, Sundvik M, Rozov S, Chen Y, Panula P. Acute ethanol treatment upregulates Th1, Th2, and Hdc in larval zebrafish in stable networks. Front Neural Circuits. 2013;7:102 pubmed publisher
    ..We found that ethanol upregulates key genes involved in the biosynthesis of histamine (hdc) and dopamine (th1 and th2) following a short 10-min ethanol treatment, measured by qPCR...
  7. Panula P, Karlstedt K, Sallmen T, Peitsaro N, Kaslin J, Michelsen K, et al. The histaminergic system in the brain: structural characteristics and changes in hibernation. J Chem Neuroanat. 2000;18:65-74 pubmed
    ..Danio rerio, histamine was detected only in the brain, where also the histamine synthesizing enzyme L-histidine decarboxylase (HDC) was expressed...
  8. Chen A, Singh C, Oikonomou G, Prober D. Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. Eneuro. 2017;4: pubmed publisher
    ..Similar to rodent genetic studies, we found that zebrafish that lack histamine due to mutation of histidine decarboxylase (hdc) exhibit largely normal sleep/wake behaviors...
  9. Chen S, Reichert S, Singh C, Oikonomou G, Rihel J, Prober D. Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 2017;95:153-168.e6 pubmed publisher
    ..These results suggest that Prok2 antagonizes the direct wake-promoting effect of light in zebrafish, in part through the induction of galn expression in the hypothalamus. ..

More Information


  1. Podlasz P, Sallinen V, Chen Y, Kudo H, Fedorowska N, Panula P. Galanin gene expression and effects of its knock-down on the development of the nervous system in larval zebrafish. J Comp Neurol. 2012;520:3846-62 pubmed publisher
    ..knockdown did not alter the expression of tyrosine hydroxylases 1 and 2, choline acetyltransferase, histidine decarboxylase, or orexin mRNA...
  2. Chen Y, Sundvik M, Rozov S, Priyadarshini M, Panula P. MANF regulates dopaminergic neuron development in larval zebrafish. Dev Biol. 2012;370:237-49 pubmed publisher
    ..Strikingly, manf mRNA could partly restore the decrease of th1 positive cells in Nr4a2-deficient larvae. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish. ..
  3. Norton W, Stumpenhorst K, Faus Kessler T, Folchert A, Rohner N, Harris M, et al. Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome. J Neurosci. 2011;31:13796-807 pubmed publisher
    ..Together, we show that a single genetic locus can underlie the aggression-boldness behavioral syndrome. We also identify one of the neurotransmitter pathways that may mediate clustering of these behaviors. ..
  4. Lin C, Taggart A, Lim K, Cygan K, Ferraris L, Creton R, et al. RNA structure replaces the need for U2AF2 in splicing. Genome Res. 2016;26:12-23 pubmed publisher
    ..While largely lost from land dwelling vertebrates, this class of introns is found in 10% of all zebrafish genes. ..
  5. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, et al. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007;5:e277 pubmed
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates. ..
  6. Puttonen H, Semenova S, Sundvik M, Panula P. Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish. Sci Rep. 2017;7:3060 pubmed publisher
    ..Our results also reveal potential new insights about the roles of monoaminergic neurotransmitters in the regulation of locomotion increase during adaptation to darkness. ..