hbegfa

Summary

Gene Symbol: hbegfa
Description: heparin-binding EGF-like growth factor a
Alias: zgc:175091, heparin-binding EGF-like growth factor
Species: zebrafish

Top Publications

  1. Wan J, Ramachandran R, Goldman D. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012;22:334-47 pubmed publisher
    ..These data provide a link between extracellular signaling and regeneration-associated gene expression in the injured retina and suggest strategies for stimulating retina regeneration in mammals. ..
  2. Tse A, Ge W. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Comp Biochem Physiol A Mol Integr Physiol. 2009;153:13-7 pubmed publisher
    ..These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members. ..
  3. Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, et al. Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 2015;524:230-3 pubmed publisher
    ..Taken together, these data reveal the activation of a compensatory network to buffer against deleterious mutations, which was not observed after translational or transcriptional knockdown. ..
  4. Nelson C, Ackerman K, O Hayer P, Bailey T, Gorsuch R, Hyde D. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration. J Neurosci. 2013;33:6524-39 pubmed publisher
    ..Thus, TNF? is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Müller glia to proliferate in the zebrafish retinal regeneration response. ..
  5. Solin S, Wang Y, Mauldin J, Schultz L, Lincow D, Brodskiy P, et al. Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis. PLoS ONE. 2014;9:e114888 pubmed publisher
    ..qRT-PCR confirmed >10-fold overexpression of the Wnt pathway components hbegfa, ascl1a, and insm1a...
  6. Tse A, Ge W. Spatial localization of EGF family ligands and receptors in the zebrafish ovarian follicle and their expression profiles during folliculogenesis. Gen Comp Endocrinol. 2010;167:397-407 pubmed publisher
    ..The functional relationship between these two signaling systems in the follicle is suggested by the observation that all four EGFR ligands examined significantly stimulated activin subunit expression in cultured follicle cells. ..
  7. Zhao X, Wan J, Powell C, Ramachandran R, Myers M, Goldman D. Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration. Cell Rep. 2014;9:272-284 pubmed publisher
    ..Our study not only furthers our understanding of retina regeneration in zebrafish but also suggests new strategies for awakening retina regeneration in mammals. ..
  8. Laisney J, Braasch I, Walter R, Meierjohann S, Schartl M. Lineage-specific co-evolution of the Egf receptor/ligand signaling system. BMC Evol Biol. 2010;10:27 pubmed publisher
    ..Furthermore, our results strongly support the use of homologous ligands in future studies, as sufficient cross-specificity is very unlikely for this ligand/receptor system. ..
  9. Zhang S, Mu Z, He C, Zhou M, Liu D, Zhao X, et al. Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Invest Ophthalmol Vis Sci. 2016;57:1991-2000 pubmed publisher
    ..Our study uncovered a novel inhibitory effect of GCV on MGPC proliferation and suggests its potential use as a tool to uncover molecular mechanisms underlying retinal regeneration in zebrafish. ..

More Information

Publications15

  1. Kenyon A, Gavriouchkina D, Zorman J, Napolitani G, Cerundolo V, Sauka Spengler T. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Sci Rep. 2017;7:6505 pubmed publisher
    ..Further perturbation of the IEGs exposes egr3 as a key transcriptional regulator controlling il1β transcription. ..
  2. Lenkowski J, Qin Z, Sifuentes C, Thummel R, Soto C, Moens C, et al. Retinal regeneration in adult zebrafish requires regulation of TGF? signaling. Glia. 2013;61:1687-97 pubmed publisher
    ..Tgif1 expression and regulation of TGF? signaling are implicated in the function of several types of stem cells, but this is the first demonstration that this regulatory network is necessary for regeneration of neurons. ..
  3. Wan J, Zhao X, Vojtek A, Goldman D. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration. Cell Rep. 2014;9:285-97 pubmed publisher
  4. Xie L, Tang Q, Yang L, Chen L. Insulin-like growth factor I promotes oocyte maturation through increasing the expression and phosphorylation of epidermal growth factor receptor in the zebrafish ovary. Mol Cell Endocrinol. 2016;419:198-207 pubmed publisher
    ..This study sheds light on the cross-talk between two important growth factors in the zebrafish ovary and the mechanism underlying the IGF-I induction on oocyte maturation. ..
  5. Miesfeld J, Gestri G, Clark B, Flinn M, Poole R, Bader J, et al. Yap and Taz regulate retinal pigment epithelial cell fate. Development. 2015;142:3021-32 pubmed publisher
  6. Schall K, Holoyda K, Grant C, Levin D, Torres E, Maxwell A, et al. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Am J Physiol Gastrointest Liver Physiol. 2015;309:G135-45 pubmed publisher
    ..We describe a technically feasible model of human SBS in the zebrafish, a faster and less expensive tool to investigate intestinal stem cell plasticity as well as the mechanisms that drive intestinal adaptation. ..