hbbe2

Summary

Gene Symbol: hbbe2
Description: hemoglobin beta embryonic-2
Alias: hemoglobin beta embryonic-2, embryonic globin beta e2
Species: zebrafish
Products:     hbbe2

Top Publications

  1. Warga R, Kane D, Ho R. Fate mapping embryonic blood in zebrafish: multi- and unipotential lineages are segregated at gastrulation. Dev Cell. 2009;16:744-55 pubmed publisher
    ..Our results demonstrate the existence of primitive hematopoietic progenitors that are segregated very early in development and that are specified to produce either a unipotent or a multipotent blood cell lineage. ..
  2. Ganis J, Hsia N, Trompouki E, de Jong J, DiBiase A, Lambert J, et al. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012;366:185-94 pubmed publisher
    ..Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching. ..
  3. Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed
    ..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
  4. Brownlie A, Donovan A, Pratt S, Paw B, Oates A, Brugnara C, et al. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998;20:244-50 pubmed
    ..As mutations in ALAS2 cause congenital sideroblastic anaemia (CSA) in humans, sau represents the first animal model of this disease. ..
  5. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  6. Zhang Z, Jia H, Zhang Q, Wan Y, Zhou Y, Jia Q, et al. Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing. BMC Genomics. 2013;14:896 pubmed publisher
    ..The present analyses demonstrate that Rpl11-deficient zebrafish may serve as a model of DBA and may provide insights into the pathogenesis of mutant RPL11-mediated human DBA disease...
  7. Nefedochkina A, Petrova N, Ioudinkova E, Kovina A, Iarovaia O, Razin S. Characterization of the enhancer element of the Danio rerio minor globin gene locus. Histochem Cell Biol. 2016;145:463-73 pubmed publisher
    ..Both enhancers appear to have emerged as a result of independent evolution of a duplicated regulatory element present in an ancestral single alpha-/beta-globin locus that existed before teleost-specific genome duplication. ..
  8. Zhou X, Zhang T, Ren L, Wu J, Wang W, Liu J. Copper elevated embryonic hemoglobin through reactive oxygen species during zebrafish erythrogenesis. Aquat Toxicol. 2016;175:1-11 pubmed publisher
    ..Moreover, we revealed that copper homeostasis was broken by its induced ROS and ROS helped with copper overloading in the body, which could be applied as a novel therapy target for copper-caused diseases. ..
  9. Cui B, Ren L, Xu Q, Yin L, Zhou X, Liu J. Silver_ nanoparticles inhibited erythrogenesis during zebrafish embryogenesis. Aquat Toxicol. 2016;177:295-305 pubmed publisher
    ..Finally, it was pointed out that AgNPs affected erythrogenesis mostly by their particles other than their releasing ions. ..

More Information

Publications16

  1. Su Z, Si W, Li L, Zhou B, Li X, Xu Y, et al. MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. Int J Biochem Cell Biol. 2014;49:53-63 pubmed publisher
    ..These findings establish miR-144 as a novel miRNA that regulates hematopoiesis and vascular development by repressing expression of meis1. ..
  2. Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, et al. Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. J Cell Sci. 2014;127:2761-70 pubmed publisher
  3. Wild R, Klems A, Takamiya M, Hayashi Y, Strahle U, Ando K, et al. Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nat Commun. 2017;8:13991 pubmed publisher
    ..Conceptually, our data suggest that spinal cord vascularization proceeds from veins involving two-tiered regulation of neuronal sFlt1 and Vegfaa via a novel sprouting mode. ..
  4. Brownlie A, Hersey C, Oates A, Paw B, Falick A, Witkowska H, et al. Characterization of embryonic globin genes of the zebrafish. Dev Biol. 2003;255:48-61 pubmed
    ..Our studies are the first to systematically evaluate the embryonic globins in the zebrafish and will ultimately be useful in evaluating zebrafish mutants with defects in hemoglobin production and switching. ..
  5. Hanaoka R, Katayama S, Dawid I, Kawahara A. Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis. Genes Cells. 2006;11:293-303 pubmed
  6. Wang H, Li Y, Wang S, Zhang Q, Zheng J, Yang Y, et al. Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish. Biochem Biophys Res Commun. 2015;460:923-30 pubmed publisher
    ..In zebrafish, injection of foxo3b-specific morpholinos (foxo3b MO) resulted in reduced globin (hbae1 and hbbe2) and gata1 gene expression...
  7. Warga R, Wicklund A, Webster S, Kane D. Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development. Dev Biol. 2016;418:307-22 pubmed publisher
    ..We conclude that while RacGAP1 function is crucial for cytokinesis and its activity at different levels controls different aspects of cytokinesis, these defects have occluded other critical roles of this interesting protein. ..