Gene Symbol: hbaa1
Description: hemoglobin, alpha adult 1
Alias: AA1, dZ118J2.2, hemoglobin subunit alpha, alpha-globin aa1, hemoglobin alpha chain
Species: zebrafish
Products:     hbaa1

Top Publications

  1. Yergeau D, Cornell C, Parker S, Zhou Y, Detrich H. bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in zebrafish. Dev Biol. 2005;283:97-112 pubmed
    ..We conclude that bty is likely to play a role in differentiation of the committed red cell progenitor. ..
  2. Ganis J, Hsia N, Trompouki E, de Jong J, DiBiase A, Lambert J, et al. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012;366:185-94 pubmed publisher
    ..Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching. ..
  3. Svoboda O, Stachura D, Machonova O, Pajer P, Brynda J, Zon L, et al. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014;124:220-8 pubmed publisher
  4. Hess I, Iwanami N, Schorpp M, Boehm T. Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Proc Natl Acad Sci U S A. 2013;110:4327-32 pubmed publisher
  5. Kovina A, Petrova N, Gushchanskaya E, Dolgushin K, Gerasimov E, Galitsyna A, et al. Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters. Mol Biol Evol. 2017;34:1492-1504 pubmed publisher
    ..These data are discussed in terms of evolution of linear and 3D organization of gene clusters in vertebrates. ..
  6. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
    ..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
  7. Guan B, Ma H, Wang Y, Hu Y, Lin Z, Zhu Z, et al. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar Biotechnol (NY). 2011;13:336-44 pubmed publisher
    ..These results suggest that that vhb gene may be an efficient candidate for genetically modifying hypoxia tolerance in fish. ..
  8. Zhang Z, Jia H, Zhang Q, Wan Y, Zhou Y, Jia Q, et al. Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing. BMC Genomics. 2013;14:896 pubmed publisher
    ..The present analyses demonstrate that Rpl11-deficient zebrafish may serve as a model of DBA and may provide insights into the pathogenesis of mutant RPL11-mediated human DBA disease...
  9. Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
    ..Globin X mRNA level was highest in oocytes, but low in later stages. Together, these data suggest a specific role for each globin, which are also associated with certain events in fish development. ..

More Information


  1. Vidal G, Scheffler B, Michel A, D Surney S. Genomic and phylogenic comparisons of the alpha-globin and beta-globin intergenic sequences between zebra fish (Danio rerio) and six closely related Cyprinindae species. DNA Cell Biol. 2004;23:325-34 pubmed
    ..This may represent an ancestral configuration prior to transposition of the alpha globin and beta-globin genes families to nonsynteny. ..
  2. Almeida D, Bianchini A, Marins L. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Gen Comp Endocrinol. 2013;194:102-9 pubmed publisher
    ..Taken together, these findings indicate that GH-transgenesis impaired the ability of juvenile zebrafish to sustain an aerobic metabolism and induced anaerobic metabolism when the fish were challenged with low oxygen levels. ..
  3. Svoboda O, Stachura D, Machonova O, Zon L, Traver D, Bartunek P. Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016;11:1007-20 pubmed publisher
    ..The present protocol should facilitate such studies on cells derived from zebrafish. ..
  4. Nishiyama T, Kaneda R, Ono T, Tohyama S, Hashimoto H, Endo J, et al. miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish. Biochem Biophys Res Commun. 2012;425:755-61 pubmed publisher
    ..The findings of the present study indicate that miR-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a. ..
  5. Chen K, Cole R, Rees B. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. J Proteomics. 2013;78:477-85 pubmed publisher
    ..These proteomic changes may contribute to the acclimation of zebrafish to hypoxia, thereby increasing their tolerance of low oxygen concentrations. ..
  6. Soza Ried C, Hess I, Netuschil N, Schorpp M, Boehm T. Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved. Proc Natl Acad Sci U S A. 2010;107:17304-8 pubmed publisher
    ..Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution. ..
  7. Mercurio S, Petrillo S, Chiabrando D, Bassi Z, Gays D, Camporeale A, et al. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica. 2015;100:720-9 pubmed publisher
    ..Consistently, reduction or increase of the cytosolic heme rescued the erythroid defects in zebrafish deficient in Flvcr1a or Flvcr1b, respectively. Thus, heme export represents a tightly regulated process that controls erythropoiesis. ..
  8. Chu C, Cheng C, Chen G, Chen Y, Hung C, Huang K, et al. The zebrafish erythropoietin: functional identification and biochemical characterization. FEBS Lett. 2007;581:4265-71 pubmed
    ..Furthermore, in the absence of functional zEpo, the expression of specific markers for adult globin genes, such as alphaA1- and betaA1-globin, but not the embryonic betae1-globin, was affected. ..
  9. Lin K, Yang Yen H, Lien H, Liao W, Huang C, Lin L, et al. Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. Sci Rep. 2016;6:31444 pubmed publisher
    ..Taking all data together, our results suggest that Trib2 positively promotes early erythrocyte differentiation and is essential for tolerance to hemolysis. ..
  10. Lin K, Ho Y, Chiang J, Li M, Lin S, Chen W, et al. Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis. Sci Rep. 2016;6:27050 pubmed publisher
    ..These results indicate that LPA2 and LPA3 play opposing roles during RBC differentiation. The pharmacological activation of LPA receptor subtypes represent a novel strategies for augmenting or inhibiting erythropoiesis. ..
  11. Krjutškov K, Koel M, Roost A, Katayama S, Einarsdottir E, Jouhilahti E, et al. Globin mRNA reduction for whole-blood transcriptome sequencing. Sci Rep. 2016;6:31584 pubmed publisher
    ..We show that GL is fully effective not only for human samples but also for mouse and rat, and so far incompletely studied cow, dog and zebrafish. ..
  12. Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D. Cold exposure down-regulates zebrafish hematopoiesis. Biochem Biophys Res Commun. 2010;394:859-64 pubmed publisher
    ..transcription factors (Runx1, scl, c-myb and GATA-2) and particularly erythropoiesis-related factors (klfd, hbaa1, ba1, GATA-1, EPO, and EPOr) was down-regulated, whereas myelopoiesis-related factors (csf1a and csf3) was up-..
  13. Dolgushin K, Petrova N, Iudinkova E, Razin S, Iarovaia O. [Joint locus of a/b-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development]. Mol Biol (Mosk). 2015;49:498-506 pubmed publisher
    ..These observations suggest that joint a/b globin gene domain of Danio rerio is segregated into two structural subdomain harboring adult and embryonic-larval globin genes. ..
  14. Eb Levadoux Y, Frelon S, Simon O, Arnaudguilhem C, Lobinski R, Mounicou S. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Metallomics. 2017;9:525-534 pubmed publisher
    ..Potential U targets were mainly involved in three biological processes: oxidative stress regulation (SOD, GST), cytoskeleton structure (actin) and embryo early development (vtg, initiation factor). ..
  15. Nefedochkina A, Petrova N, Ioudinkova E, Kovina A, Iarovaia O, Razin S. Characterization of the enhancer element of the Danio rerio minor globin gene locus. Histochem Cell Biol. 2016;145:463-73 pubmed publisher
    ..Both enhancers appear to have emerged as a result of independent evolution of a duplicated regulatory element present in an ancestral single alpha-/beta-globin locus that existed before teleost-specific genome duplication. ..