Gene Symbol: gucy2f
Description: guanylate cyclase 2F, retinal
Alias: RETGC-1, gc1, olfactory guanylyl cyclase GC-D, guanylyl cyclase 1
Species: zebrafish

Top Publications

  1. Rätscho N, Scholten A, Koch K. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochim Biophys Acta. 2009;1793:1110-4 pubmed publisher
    ..High guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and zGCAPs coincide with the onset of visual function at 3-4 dpf. ..
  2. Gao D, Wang C, Xi Z, Zhou Y, Wang Y, Zuo Z. Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved. Toxicol Sci. 2017;157:74-84 pubmed publisher
    ..5. Guanylate cyclase 2F (gucy2f) and dopamine receptor D4 related sequence (drd4-rs) were hypermethylation promoters, whereas zinc finger C4H2 ..
  3. Maddison L, Lu J, Victoroff T, Scott E, Baier H, Chen W. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Mol Genet Genomics. 2009;281:551-63 pubmed publisher
    ..We further demonstrate that misexpression of one such downstream gene gucy2F, a membrane-bound guanylate cyclase, throughout the nervous system results in multiple defects including a loss of ..
  4. Morris A, Forbes Osborne M, Pillai L, Fadool J. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci. 2011;52:2255-66 pubmed publisher
  5. Saraiva L, Ahuja G, Ivandić I, Syed A, Marioni J, Korsching S, et al. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Sci Rep. 2015;5:11487 pubmed publisher
    ..In sum, we find that the molecular and cellular mechanisms underpinning olfaction in teleosts and mammals are similar despite 430 million years of evolutionary divergence. ..
  6. Brockerhoff S, Rieke F, Matthews H, Taylor M, Kennedy B, Ankoudinova I, et al. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci. 2003;23:470-80 pubmed
    ..Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm. ..
  7. Stiebel Kalish H, Reich E, Rainy N, Vatine G, Nisgav Y, Tovar A, et al. Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis. Eur J Hum Genet. 2012;20:884-9 pubmed publisher
    ..photoreceptor-specific GUCY2D-related LCA1, by reporting the visual phenotype and retinal histology resulting from Gucy2f knockdown. Gucy2f zebrafish LCA-orthologous cDNA was identified and isolated by PCR amplification...