Gene Symbol: gucy2f
Description: guanylate cyclase 2F, retinal
Alias: RETGC-1, gc1, olfactory guanylyl cyclase GC-D, guanylyl cyclase 1
Rätscho N, Scholten A, Koch K. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochim Biophys Acta. 2009;1793:1110-4 pubmed publisher
..High guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and zGCAPs coincide with the onset of visual function at 3-4 dpf. ..
Gao D, Wang C, Xi Z, Zhou Y, Wang Y, Zuo Z. Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved. Toxicol Sci. 2017;157:74-84 pubmed publisher
..5. Guanylate cyclase 2F (gucy2f) and dopamine receptor D4 related sequence (drd4-rs) were hypermethylation promoters, whereas zinc finger C4H2 ..
Maddison L, Lu J, Victoroff T, Scott E, Baier H, Chen W. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Mol Genet Genomics. 2009;281:551-63 pubmed publisher
..We further demonstrate that misexpression of one such downstream gene gucy2F, a membrane-bound guanylate cyclase, throughout the nervous system results in multiple defects including a loss of ..
Morris A, Forbes Osborne M, Pillai L, Fadool J. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci. 2011;52:2255-66 pubmed publisher
Saraiva L, Ahuja G, Ivandić I, Syed A, Marioni J, Korsching S, et al
. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Sci Rep. 2015;5:11487 pubmed publisher
..In sum, we find that the molecular and cellular mechanisms underpinning olfaction in teleosts and mammals are similar despite 430â€‰million years of evolutionary divergence. ..
Brockerhoff S, Rieke F, Matthews H, Taylor M, Kennedy B, Ankoudinova I, et al
. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci. 2003;23:470-80 pubmed
..Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm. ..
Stiebel Kalish H, Reich E, Rainy N, Vatine G, Nisgav Y, Tovar A, et al
. Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis. Eur J Hum Genet. 2012;20:884-9 pubmed publisher
..photoreceptor-specific GUCY2D-related LCA1, by reporting the visual phenotype and retinal histology resulting from Gucy2f knockdown. Gucy2f zebrafish LCA-orthologous cDNA was identified and isolated by PCR amplification...