Gene Symbol: gucy2d
Description: guanylate cyclase 2D, retinal
Alias: GUCY2d1, RETGC-3, gc3, guanylyl cyclase 3, zat, zatoichi
Species: zebrafish

Top Publications

  1. Brockerhoff S, Rieke F, Matthews H, Taylor M, Kennedy B, Ankoudinova I, et al. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci. 2003;23:470-80 pubmed
    ..Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm. ..
  2. Fries R, Scholten A, Säftel W, Koch K. Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors. PLoS ONE. 2013;8:e69656 pubmed publisher
    ..Its physiological function is therefore compensated by other zGCAP isoforms. ..
  3. Tsai H, Hamilton A, Tinch A, Guy D, Gharbi K, Stear M, et al. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 2015;16:969 pubmed publisher
    ..The results have practical relevance for genomic selection in salmon and may also provide insight into variation in the identified genes underpinning body growth and development in salmonid species. ..
  4. Iribarne M, Nishiwaki Y, Nakamura S, Araragi M, Oguri E, Masai I. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep. 2017;7:45962 pubmed publisher
    ..Furthermore, zGc3 knockdown embryos showed a marked reduction in Pde6c. These observations illustrate the interdependence of cGMP metabolism regulators between Aipl1, Pde6c, and Gc3 in photoreceptors.
  5. Muto A, Orger M, Wehman A, Smear M, Kay J, Page McCaw P, et al. Forward genetic analysis of visual behavior in zebrafish. PLoS Genet. 2005;1:e66 pubmed
    ..This collection of zebrafish behavioral mutants provides a novel resource for the study of normal vision and its genetic disorders. ..
  6. Rätscho N, Scholten A, Koch K. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochim Biophys Acta. 2009;1793:1110-4 pubmed publisher
    ..High guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and zGCAPs coincide with the onset of visual function at 3-4 dpf. ..
  7. Saraiva L, Ahuja G, Ivandić I, Syed A, Marioni J, Korsching S, et al. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Sci Rep. 2015;5:11487 pubmed publisher
    ..In sum, we find that the molecular and cellular mechanisms underpinning olfaction in teleosts and mammals are similar despite 430 million years of evolutionary divergence. ..