Gene Symbol: guca1a
Description: guanylate cyclase activator 1A
Alias: gcap1, guanylyl cyclase-activating protein 1
Imanishi Y, Li N, Sokal I, Sowa M, Lichtarge O, Wensel T, et al
. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002;15:63-78 pubmed
..The guanylate cyclase-activating proteins 1-3 (GCAP1-3), the best characterized subgroup of NCBPs, function in the regulation of transmembrane guanylate cyclases 1-2 (..
Brockerhoff S, Rieke F, Matthews H, Taylor M, Kennedy B, Ankoudinova I, et al
. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci. 2003;23:470-80 pubmed
..Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm. ..
Shen Y, Raymond P. Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis. Dev Biol. 2004;269:237-51 pubmed
..These results suggest novel functions for zebrafish crx during retinal specification and differentiation. ..
Scholten A, Koch K. Differential calcium signaling by cone specific guanylate cyclase-activating proteins from the zebrafish retina. PLoS ONE. 2011;6:e23117 pubmed publisher
..1-5 µM) and/or low (? 5 µM) affinity, but were unique for each zGCAP isoform. Our data indicate a Ca(2+)-sensor system in zebrafish rod and cone cells supporting a Ca(2+)-relay model of differential zGCAP operation in these cells. ..
Chen X, Sheng X, Zhuang W, Sun X, Liu G, Shi X, et al
. GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity. Genet Med. 2017;19:945-954 pubmed publisher
..Zebrafish models were used to investigate the pathogenesis of GUCA1A mutations. A novel mutation, GUCA1A p...
Lu Z, Hu X, Liu F, Soares D, Liu X, Yu S, et al
. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep. 2017;7:46098 pubmed publisher
Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004;59:204-217 pubmed publisher
..Based on genome searches and EST analyses, the mouse and human genomes do not harbor GCAP4-8 or GCIP genes. ..
Sulmann S, Vocke F, Scholten A, Koch K. Retina specific GCAPs in zebrafish acquire functional selectivity in Ca2+-sensing by myristoylation and Mg2+-binding. Sci Rep. 2015;5:11228 pubmed publisher
..Hydrodynamic properties of zGCAPs are more influenced by Ca(2+) than by Mg(2+), although to a different extent for each zGCAP. Posttranslational modification and competing ion-binding can tailor the properties of similar Ca(2+)-sensors. ..
Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al
. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
..We conclude that CERKL deficiency in zebrafish may cause rod-cone dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associated with down-regulation of the expression of MERTK. ..