Gene Symbol: gstm.1
Description: glutathione S-transferase mu, tandem duplicate 1
Alias: cb760, gstm, wu:fc26g06, zgc:66370, glutathione S-transferase mu, tandem duplicate 1, glutathione S-transferase M
Species: zebrafish

Top Publications

  1. Parolini M, Ghilardi A, Della Torre C, Magni S, Prosperi L, Calvagno M, et al. Environmental concentrations of cocaine and its main metabolites modulated antioxidant response and caused cyto-genotoxic effects in zebrafish embryo cells. Environ Pollut. 2017;226:504-514 pubmed publisher
    ..Our data confirmed the potential toxicity of environmental concentrations of COC, BE, and EME, suggesting the need of further in-depth studies to shed light on their MoA and long-term toxicity towards non-target aquatic species. ..
  2. Liu W, Guan Y, Collodi P. A zebrafish cell culture assay for the identification of microRNA targets. Zebrafish. 2010;7:343-8 pubmed publisher
    ..The cell culture-based assay could be used to validate target sequences of other zebrafish miRNAs. ..
  3. Christen V, Faltermann S, Brun N, Kunz P, Fent K. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. Sci Total Environ. 2017;586:1204-1218 pubmed publisher
    ..Barquat and BAC let to induction of ER stress and inflammation in vitro, and BAC and glutaraldehyde at non-toxic concentrations in vivo, while benzalkonium chloride induced expression of tnf-? only. ..
  4. Mukhopadhyay D, Chattopadhyay A. Induction of oxidative stress and related transcriptional effects of sodium fluoride in female zebrafish liver. Bull Environ Contam Toxicol. 2014;93:64-70 pubmed publisher
    ..ROS generation was evidensed by fluoroscence microscopy. The results of this study will help to understand the mechanism of oxidative stress induced by NaF in fish. ..
  5. Liu L, Xu Y, Xu L, Wang J, Wu W, Xu L, et al. Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:183-9 pubmed
    ..These data may help us understand the functions and the molecular mechanisms of these proteins in zebrafish embryos' response to CPF exposure. ..
  6. Glisic B, Mihaljević I, Popovic M, Zaja R, Loncar J, Fent K, et al. Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquat Toxicol. 2015;158:50-62 pubmed publisher
    ..Our data revealed ubiquitously high expression of gstp, gstm (except in liver), gstr1, mgst3a and mgst3b, high expression of gsto2 in gills and ovaries, gsta in intestine and ..
  7. da Rosa C, Figueiredo M, Lanes C, Almeida D, Marins L. Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model. Transgenic Res. 2011;20:85-9 pubmed publisher
    ..The GH-transgenic zebrafish model used here seems to be an interesting tool for analyzing the effect of different GH expression levels on physiological processes. ..
  8. Faltermann S, Hutter S, Christen V, Hettich T, Fent K. Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio). Toxins (Basel). 2016;8: pubmed publisher
    ..The data further demonstrate that pathways that are influenced by microcystin-LR are not affected by aeruginosin 828A. ..
  9. Hrubik J, Glisic B, Fa S, Pogrmic Majkic K, Andric N. Erk-Creb pathway suppresses glutathione-S-transferase pi expression under basal and oxidative stress conditions in zebrafish embryos. Toxicol Lett. 2016;240:81-92 pubmed publisher
    ..This study also provides a novel link between Erk and gstp1-2 expression, setting apart a possible differential regulation of gstp1-2 in adult and embryonic cells. ..

More Information


  1. Mukhopadhyay D, Priya P, Chattopadhyay A. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Environ Toxicol Pharmacol. 2015;40:352-9 pubmed publisher
    ..Nrf2/Keap1 proteins had similar expression pattern as their corresponding mRNA. The findings in this study might help to understand the molecular mechanism of fluoride induced neurotoxicity in fish. ..
  2. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  3. Chen D, Chan K. Differentially expressed proteins in zebrafish liver cells exposed to copper. Aquat Toxicol. 2011;104:270-7 pubmed publisher
    ..However, the regulation of several proteins in ZFL, related to the reactive oxygen species (ROS) effect, mitochondrion copper transportation and stress response, was quite different from that in tilapia. ..
  4. Li G, Xie P, Fu J, Hao L, Xiong Q, Li H. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish. Aquat Toxicol. 2008;88:75-80 pubmed publisher
    ..These results suggested that the transcription of GST isoforms varied in different ways within an organ and among organs of goldfish exposed to MCs. ..
  5. Makino S, Mishima Y, Inoue K, Inada T. Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast. J Biol Chem. 2015;290:8331-47 pubmed publisher
  6. Rola R, Marins L, Nery L, da Rosa C, Sandrini J. Responses to ROS inducer agents in zebrafish cell line: differences between copper and UV-B radiation. Fish Physiol Biochem. 2014;40:1817-25 pubmed publisher
    ..In conclusion, these results demonstrated that both toxicants could increase ROS levels in ZFL cell line, but the responses are different, which could be related to activation of different signaling pathways. ..
  7. Brun N, Wehrli B, Fent K. Ecotoxicological assessment of solar cell leachates: Copper indium gallium selenide (CIGS) cells show higher activity than organic photovoltaic (OPV) cells. Sci Total Environ. 2016;543:703-14 pubmed publisher
    ..Addition of ethylenediaminetetraacetic acid protected zebrafish embryos from morphological and molecular effects. Our study suggests that metals leaching from damaged CIGS cells, may pose a potential environmental risk. ..
  8. Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
    ..This is probably due to action to specific organs such as liver and kidneys that could not be identified by whole-embryo sampling. ..
  9. Mishima Y, Tomari Y. Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Mol Cell. 2016;61:874-85 pubmed publisher
    ..Our study thus highlights the codon-mediated mRNA decay as a conserved regulatory mechanism in eukaryotes. ..
  10. Carlson P, Smalley D, Van Beneden R. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Toxicol Sci. 2013;134:83-91 pubmed publisher
    ..The changes presented here seem to be most prevalent in lipid transport and metabolic pathways, suggesting a potential increase in fibrosis in males and decreased lipid accumulation and uptake in females. ..
  11. Liu Y, Zhu Z, Ho I, Shi Y, Xie Y, Li J, et al. Germline-specific dgcr8 knockout in zebrafish using a BACK approach. Cell Mol Life Sci. 2017;74:2503-2511 pubmed publisher
    ..Our findings establish that Cre/loxP-mediated tissue-specific gene knockout could be achieved using this BACK strategy and that canonical microRNAs play important roles in early embryonic development in zebrafish. ..