Gene Symbol: gsk3ab
Description: glycogen synthase kinase 3 alpha b
Alias: GSK-3[a], GSK-3[b], GSK3, gsk3a, glycogen synthase kinase-3 alpha
Shimizu T, Yamanaka Y, Ryu S, Hashimoto H, Yabe T, Hirata T, et al
. Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mech Dev. 2000;91:293-303 pubmed
Zhong H, Zou H, Semenov M, Moshinsky D, He X, Huang H, et al
. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol Biosyst. 2009;5:1356-60 pubmed publisher
Glycogen synthase kinase 3 (GSK3) is an essential component of the Wnt signaling pathway and plays important roles in regulating cell proliferation, differentiation, and apoptosis...
Finkielsztein A, Kelly G. Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation. Biol Cell. 2009;101:661-78, 4 p following 678 pubmed publisher
..We propose a model in which homoeostasis in rapidly dividing and migrating embryonic cells depends on a counterbalance between pro-survival signalling employing CK2 and GSK-3 and the pro-apoptotic activity of Ptena454. ..
Du L, Xu J, Li X, Ma N, Liu Y, Peng J, et al
. Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Development. 2011;138:619-29 pubmed publisher
..Our study identifies Rumba and Haus3 as two essential regulators of HSPC maintenance during zebrafish fetal hematopoiesis. ..
De Servi B, Hermani A, Medunjanin S, Mayer D. Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells. Oncogene. 2005;24:4946-55 pubmed
..ERalpha was not phosphorylated by PKCdelta; however, glycogen synthase kinase-3 (GSK3) was identified as a substrate of PKCdelta...
Lee H, Tsai J, Liao P, Tsai W, Lin K, Chuang C, et al
. Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev Biol. 2007;7:93 pubmed
Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes. Two closely related GSK3 isoforms encoded by distinct genes: GSK3alpha (51 kDa) and GSK3beta (47 kDa)...
Ung C, Lam S, Hlaing M, Winata C, Korzh S, Mathavan S, et al
. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 2010;11:212 pubmed publisher
..oxidative stresses, intrinsic apoptotic pathway, deregulation of nuclear receptor and kinase activities including Gsk3 that deregulates Wnt signaling pathway, gluconeogenesis, and adipogenesis, leading to mitochondrial dysfunction, ..