Gene Symbol: gpx4b
Description: glutathione peroxidase 4b
Alias: PHGPxb, cb692, zgc:110018, glutathione peroxidase 4b
Species: zebrafish

Top Publications

  1. Thisse C, Degrave A, Kryukov G, Gladyshev V, Obrecht Pflumio S, Krol A, et al. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003;3:525-32 pubmed
    ..Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. ..
  2. Miller G, Labut E, Lebold K, Floeter A, Tanguay R, Traber M. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. J Nutr Biochem. 2012;23:478-86 pubmed publisher
    ..05) at 120 h post-fertillization than embryos from parents fed E+ or lab diets. This study documents for the first time that vitamin E is essential for normal zebrafish embryonic development. ..
  3. Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
  4. Dhanasiri A, Fernandes J, Kiron V. Liver transcriptome changes in zebrafish during acclimation to transport-associated stress. PLoS ONE. 2013;8:e65028 pubmed publisher
    ..Thus, this study has revealed the complex molecular adjustments that occur in zebrafish when they are transported...
  5. Mendieta Serrano M, Schnabel D, Lomelí H, Salas Vidal E. Spatial and temporal expression of zebrafish glutathione peroxidase 4 a and b genes during early embryo development. Gene Expr Patterns. 2015;19:98-107 pubmed publisher
    ..We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene ..
  6. Karami A, Groman D, Wilson S, Ismail P, Neela V. Biomarker responses in zebrafish (Danio rerio) larvae exposed to pristine low-density polyethylene fragments. Environ Pollut. 2017;223:466-475 pubmed publisher
    ..We provide evidence that virgin short-term exposure to LDPE fragments has minimal impact on biomarker responses in D. rerio larvae. ..
  7. Rong X, Zhou Y, Liu Y, Zhao B, Wang B, Wang C, et al. Glutathione peroxidase 4 inhibits Wnt/?-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development. 2017;144:1687-1697 pubmed publisher
    ..Here, we show that maternal loss of zebrafish gpx4b promotes embryonic dorsal organizer formation, whereas overexpression of gpx4b inhibits the development ..
  8. Kryukov G, Gladyshev V. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000;5:1049-60 pubmed
    ..Our data also suggest that the utilization of Sec is more common in zebrafish than in previously characterized species, including mammals. ..
  9. Kelkar D, Provost E, Chaerkady R, Muthusamy B, Manda S, Subbannayya T, et al. Annotation of the zebrafish genome through an integrated transcriptomic and proteomic analysis. Mol Cell Proteomics. 2014;13:3184-98 pubmed publisher
    ..Our study shows how an integrative analysis of the transcriptome and the proteome can extend our understanding of even well-annotated genomes. ..

More Information


  1. Betancor M, Almaida Pagán P, Sprague M, Hernández A, Tocher D. Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Fish Physiol Biochem. 2015;41:705-20 pubmed publisher
    ..These data suggest that oxidative stress protection associated with a high dietary intake of Se may not be solely mediated by transcriptional changes in teleost selenoprotein expression. ..
  2. Stancová V, Ziková A, Svobodová Z, Kloas W. Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2015;40:343-8 pubmed publisher
    ..Interestingly, the adverse side effects of NSAIDs occur in the gastrointestinal tract of humans. To our knowledge, this is the first study that has focused on transcriptional effects of naproxen on zebrafish. ..