gpx4a

Summary

Gene Symbol: gpx4a
Description: glutathione peroxidase 4a
Alias: PHGPxa, cb563, cb691, sb:cb563, wu:fb82e03, zgc:92253, glutathione peroxidase 4a
Species: zebrafish

Top Publications

  1. Gentès S, Maury Brachet R, Feng C, Pedrero Z, Tessier E, Legeay A, et al. Specific Effects of Dietary Methylmercury and Inorganic Mercury in Zebrafish (Danio rerio) Determined by Genetic, Histological, and Metallothionein Responses. Environ Sci Technol. 2015;49:14560-9 pubmed publisher
    ..In brain, high MeHg and iHg concentrations induced metallothionein production. Finally, the importance of the fish origin in ecotoxicological studies, here the seventh descent of a zebrafish line, is discussed. ..
  2. Rong X, Zhou Y, Liu Y, Zhao B, Wang B, Wang C, et al. Glutathione peroxidase 4 inhibits Wnt/?-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development. 2017;144:1687-1697 pubmed publisher
    ..Our findings unravel GPX4 as a suppressor of Wnt/?-catenin signals, suggesting a possible relationship between the Wnt/?-catenin pathway and selenium via the association of Tcf/Lef family proteins with GPX4. ..
  3. Kryukov G, Gladyshev V. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000;5:1049-60 pubmed
    ..Our data also suggest that the utilization of Sec is more common in zebrafish than in previously characterized species, including mammals. ..
  4. Thisse C, Degrave A, Kryukov G, Gladyshev V, Obrecht Pflumio S, Krol A, et al. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003;3:525-32 pubmed
    ..Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. ..
  5. Miller G, Labut E, Lebold K, Floeter A, Tanguay R, Traber M. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. J Nutr Biochem. 2012;23:478-86 pubmed publisher
    ..05) at 120 h post-fertillization than embryos from parents fed E+ or lab diets. This study documents for the first time that vitamin E is essential for normal zebrafish embryonic development. ..
  6. Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
  7. Benner M, Settles M, Murdoch G, Hardy R, Robison B. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Physiol Genomics. 2013;45:653-66 pubmed publisher
    ..In nutritional intervention studies, it may be necessary to utilize methods such as qRT-PCR, which allow larger sample sizes, for detecting subtle transcriptional changes in the brain. ..
  8. Perrichon P, Akcha F, Le Menach K, Goubeau M, Budzinski H, Cousin X, et al. Parental trophic exposure to three aromatic fractions of polycyclic aromatic hydrocarbons in the zebrafish: Consequences for the offspring. Sci Total Environ. 2015;524-525:52-62 pubmed publisher
    ..The disruptions observed at the individual level in the next generation could impact on the longer-term, surviving population. ..
  9. Mendieta Serrano M, Schnabel D, Lomelí H, Salas Vidal E. Spatial and temporal expression of zebrafish glutathione peroxidase 4 a and b genes during early embryo development. Gene Expr Patterns. 2015;19:98-107 pubmed publisher
    ..We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only...

More Information

Publications12

  1. Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher
    ..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..
  2. Perrichon P, Le Menach K, Akcha F, Cachot J, Budzinski H, Bustamante P. Toxicity assessment of water-accommodated fractions from two different oils using a zebrafish (Danio rerio) embryo-larval bioassay with a multilevel approach. Sci Total Environ. 2016;568:952-966 pubmed publisher
    ..Our work highlights once more, the cardiotoxic action (and potentially neurotoxic) of petroleum-related PAHs. ..
  3. Haggard D, Noyes P, Waters K, Tanguay R. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol. 2016;308:32-45 pubmed publisher
    ..We observed similarities in gene expression and hepatic steatosis assays; however, hit data for TCS were more concordant with the hypothesized CAR/PXR activity of TCS from rodent and human in vitro studies. ..