Gene Symbol: gpx1b
Description: glutathione peroxidase 1b
Alias: wu:fd42f12, wu:fj22d06, zgc:101700, glutathione peroxidase 1b
Kryukov G, Gladyshev V. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000;5:1049-60 pubmed
..Our data also suggest that the utilization of Sec is more common in zebrafish than in previously characterized species, including mammals. ..
Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
Thisse C, Degrave A, Kryukov G, Gladyshev V, Obrecht Pflumio S, Krol A, et al
. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003;3:525-32 pubmed
..Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. ..
Rawls J, Samuel B, Gordon J. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc Natl Acad Sci U S A. 2004;101:4596-601 pubmed
..Together, these studies establish gnotobiotic zebrafish as a useful model for dissecting the molecular foundations of host-microbial interactions in the vertebrate digestive tract. ..
Kanther M, Sun X, Muhlbauer M, Mackey L, Flynn E, Bagnat M, et al
. Microbial colonization induces dynamic temporal and spatial patterns of NF-?B activation in the zebrafish digestive tract. Gastroenterology. 2011;141:197-207 pubmed publisher
..The observed patterns of NF-?B-dependent responses to microbial colonization indicate that cells in the gastrointestinal tract respond robustly to the microbial environment. ..
Zancan I, Bellesso S, Costa R, Salvalaio M, Stroppiano M, Hammond C, et al
. Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/Î²-catenin signaling. Hum Mol Genet. 2015;24:1280-94 pubmed publisher
..Our results support a novel model in which a primary defect in canonical Wnt signaling antecedes bone defects in type 1 GD. ..
Seiler C, Davuluri G, Abrams J, Byfield F, Janmey P, Pack M. Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol. 2012;10:e1001386 pubmed publisher
..In addition, they identify an inducible physical signaling pathway sensitive to redox and oncogenic signaling that can drive this process...
Penglase S, Hamre K, Rasinger J, Ellingsen S. Selenium status affects selenoprotein expression, reproduction, and F? generation locomotor activity in zebrafish (Danio rerio). Br J Nutr. 2014;111:1918-31 pubmed publisher
..including glutathione peroxidase (GPX) activity, the mRNA expression of key Se-dependent proteins (gpx1a, gpx1b, sepp1a and sepp1b), oxidative status, reproductive success and F1 generation locomotor activity...
Knecht A, Goodale B, Truong L, Simonich M, Swanson A, Matzke M, et al
. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol. 2013;271:266-75 pubmed publisher
..Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms...