Gene Symbol: gpc1a
Description: glypican 1a
Alias: Gpc1, si:rp71-69p9.1, zgc:122977, glypican-1, heparan sulfate proteoglycan
Wang H. Comparative analysis of period genes in teleost fish genomes. J Mol Evol. 2008;67:29-40 pubmed publisher
Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al
. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
..3 in patients with BA that resulted in deletion of one copy of GPC1, which encodes glypican 1, a heparan sulfate proteoglycan that regulates Hedgehog signaling and inflammation...
Hogl S, van Bebber F, Dislich B, Kuhn P, Haass C, Schmid B, et al
. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 2013;13:1519-27 pubmed publisher
Gupta M, Brand M. Identification and expression analysis of zebrafish glypicans during embryonic development. PLoS ONE. 2013;8:e80824 pubmed publisher
..Some of the fish glypicans like Gpc1a, Gpc3, Gpc4, Gpc6a and Gpc6b show conserved synteny with their mammalian cognate genes...
Tang V, COFER Z, Cui S, Sapp V, Loomes K, Matthews R. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr. 2016;63:524-530 pubmed
..Combined knockdown of add3a and glypican-1 (gpc1), another mediator of Hh activity that is also a BA susceptibility gene, resulted in more severe biliary defects ..