Gene Symbol: golden
Description: solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
Alias: sodium/potassium/calcium exchanger 5, K-dependent Na,Ca exchanger 5, Na(+)/K(+)/Ca(2+)-exchange protein 5, gol, gol-1, golden, golden-1, protein golden, solute carrier family 24, member 5
Species: zebrafish
Products:     golden

Top Publications

  1. Wittkopp N, Huntzinger E, Weiler C, Sauliere J, Schmidt S, Sonawane M, et al. Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol. 2009;29:3517-28 pubmed publisher
    ..Our results together with previous studies show that NMD effectors are essential for vertebrate embryogenesis and suggest that the coupling of splicing and NMD has been maintained in vertebrates but lost in fungi and invertebrates. ..
  2. Kelsh R, Brand M, Jiang Y, Heisenberg C, Lin S, Haffter P, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-89 pubmed
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  3. Dahlem T, Hoshijima K, Jurynec M, Gunther D, Starker C, Locke A, et al. Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome. PLoS Genet. 2012;8:e1002861 pubmed publisher
    ..In all, it takes about two weeks to create a target-specific TALEN and generate growing embryos that harbor an array of germ line mutations at a pre-specified locus. ..
  4. Lamason R, Mohideen M, Mest J, Wong A, Norton H, Aros M, et al. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science. 2005;310:1782-6 pubmed
    ..Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that ..
  5. Doyon Y, McCammon J, Miller J, Faraji F, Ngo C, Katibah G, et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 2008;26:702-8 pubmed publisher
    ..We designed ZFNs targeting the zebrafish golden and no tail/Brachyury (ntl) genes and developed a budding yeast-based assay to identify the most active ZFNs for ..
  6. Yeyati P, Bancewicz R, Maule J, van Heyningen V. Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet. 2007;3:e43 pubmed
  7. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase. ..
  8. Anastasaki C, Longman D, Capper A, Patton E, Caceres J. Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res. 2011;39:3686-94 pubmed publisher
  9. Müller J, Kelsh R. A golden clue to human skin colour variation. Bioessays. 2006;28:578-82 pubmed
    ..Now, cloning of a classic zebrafish mutant, golden, identifies slc24a5 as a gene involved in fish skin pigmentation...

More Information


  1. Brown S, Tucker C, Ford C, Lee Y, Dunbar D, Mullins J. Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish. J Leukoc Biol. 2007;82:79-84 pubmed
    ..Our results suggest that ERG-specific Class III antiarrhythmic drugs can modulate inflammatory responses to infection. ..
  2. Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, et al. Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun. 2016;7:11288 pubmed publisher
    ..The combination of these developmental and cellular mechanisms prevents organ fusion, controls organ positioning and is thus critical for its proper function. ..
  3. Pauli A, Montague T, Lennox K, Behlke M, Schier A. Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish. PLoS ONE. 2015;10:e0139504 pubmed publisher
    ..Despite this drawback, quantitation of knockdown efficiency and the ability to degrade lncRNAs make ASOs a useful knockdown reagent in zebrafish. ..
  4. Jao L, Wente S, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A. 2013;110:13904-9 pubmed publisher
    ..1mnx1:egfp) and four endogenous loci (tyr, golden, mitfa, and ddx19). Mutagenesis rates reached 75-99%, indicating that most cells contained biallelic mutations...
  5. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis. ..
  6. Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, et al. Mutations affecting pigmentation and shape of the adult zebrafish. Dev Genes Evol. 1996;206:260-76 pubmed publisher
    ..Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish. ..
  7. Gupta A, Hall V, Kok F, Shin M, McNulty J, Lawson N, et al. Targeted chromosomal deletions and inversions in zebrafish. Genome Res. 2013;23:1008-17 pubmed publisher
    ..The ability to efficiently delete genomic segments in a vertebrate developmental system will facilitate the study of functional noncoding elements on an organismic level...
  8. Ota S, Hisano Y, Ikawa Y, Kawahara A. Multiple genome modifications by the CRISPR/Cas9 system in zebrafish. Genes Cells. 2014;19:555-64 pubmed publisher
    ..Multiple genes including golden/gol and tyrosinase/tyr, which are involved in pigment formation, and s1pr2 and spns2, which are involved in ..
  9. Tsetskhladze Z, Canfield V, Ang K, Wentzel S, Reid K, Berg A, et al. Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS ONE. 2012;7:e47398 pubmed publisher
    ..Introduction of the L374F polymorphism into albino or the A111T polymorphism into slc24a5 (golden) abolished mRNA rescue of the respective mutant phenotypes, consistent with their known contributions to European ..
  10. Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, et al. Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development. 2016;143:2025-37 pubmed publisher
  11. Liao H, Essner J. Use of RecA fusion proteins to induce genomic modifications in zebrafish. Nucleic Acids Res. 2011;39:4166-79 pubmed publisher
    ..filaments with chimeric RecA proteins were tested for the ability to induce loss of heterozygosity at the golden locus in zebrafish after injection at the one-cell stage...
  12. Hattori M, Hashimoto H, Bubenshchikova E, Wakamatsu Y. Nuclear transfer of embryonic cell nuclei to non-enucleated eggs in zebrafish, Danio rerio. Int J Biol Sci. 2011;7:460-8 pubmed
    ..we transferred blastula cell nuclei from a wild-type donor strain to non-enucleated, unfertilized eggs from a golden recipient strain. As a result, 31 of 184 (16.8%) operated eggs developed normally and reached the adult stage...