gnrhr1

Summary

Gene Symbol: gnrhr1
Description: gonadotropin releasing hormone receptor 1
Alias: gonadotropin releasing hormone receptor 1, GnRH-R1PEY
Species: zebrafish

Top Publications

  1. Tello J, Wu S, Rivier J, Sherwood N. Four functional GnRH receptors in zebrafish: analysis of structure, signaling, synteny and phylogeny. Integr Comp Biol. 2008;48:570-87 pubmed publisher
    ..The differences in structure, location, and response to GnRH forms strongly suggests that the four zebrafish GnRH receptors have novel functions in addition to the conventional activation of the pituitary gland in the reproductive axis. ..
  2. Corchuelo S, Martinez E, Butzge A, Doretto L, Ricci J, Valentin F, et al. Characterization of Gnrh/Gnih elements in the olfacto-retinal system and ovary during zebrafish ovarian maturation. Mol Cell Endocrinol. 2017;450:1-13 pubmed publisher
    ..Our results suggested that Gnrh/Gnih elements are involved in the neuromodulation of the sensorial system particularly at the final stages of maturation, playing also a paracrine role in the ovary. ..
  3. Xu Q, Wu D, Dang Y, Yu L, Liu C, Wang J. Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP. Aquat Toxicol. 2017;182:163-171 pubmed publisher
  4. Ji K, Hong S, Kho Y, Choi K. Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. Environ Sci Technol. 2013;47:8793-800 pubmed publisher
    ..Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring. ..
  5. Jo A, Ji K, Choi K. Endocrine disruption effects of long-term exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in zebrafish (Danio rerio) and related mechanisms. Chemosphere. 2014;108:360-6 pubmed publisher
    ..Consequences of endocrine disruptions in reproduction performances of the fish warrant further investigation. ..
  6. Kwon B, Shin H, Moon H, Ji K, Kim K. Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio). Environ Pollut. 2016;214:568-574 pubmed publisher
  7. Khor Y, Soga T, Parhar I. Early-life stress changes expression of GnRH and kisspeptin genes and DNA methylation of GnRH3 promoter in the adult zebrafish brain. Gen Comp Endocrinol. 2016;227:84-93 pubmed publisher
    ..Hence, early-life DEX treatment can alter methylation of GnRH3 gene promoter, which subsequently affects gene regulation and reproductive functions. ..
  8. Yu M, Zhang X, Guo L, Tian H, Wang W, Ru S. Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms. Aquat Toxicol. 2016;170:262-270 pubmed publisher
    ..These effects were observed at environmentally relevant concentrations and highlight the importance of controlling SMC contamination. ..
  9. Liu W, Chen C, Chen L, Wang L, Li J, Chen Y, et al. Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish. Sci Rep. 2016;6:22819 pubmed publisher
    ..In conclusion, this study first investigated the sex-dependent effects of microcystins on fish reproduction and revealed some important molecular biomarkers related to gametogenesis in zebrafish suffered from MC-LR. ..

More Information

Publications17

  1. Yang Q, Yang X, Liu J, Ren W, Chen Y, Shen S. Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic-pituitary-gonadal axis of zebrafish. Environ Sci Pollut Res Int. 2017;24:21311-21322 pubmed publisher
    ..These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females. ..
  2. Lethimonier C, Madigou T, Muñoz Cueto J, Lareyre J, Kah O. Evolutionary aspects of GnRHs, GnRH neuronal systems and GnRH receptors in teleost fish. Gen Comp Endocrinol. 2004;135:1-16 pubmed
    ..This paper intends to summarize the current situation with special emphasis on interspecies comparisons which provide insights into the possible evolutionary mechanisms leading to the diversification of GnRH functions. ..
  3. Dang Y, Wang J, Giesy J, Liu C. Responses of the zebrafish hypothalamic-pituitary-gonadal-liver axis PCR array to prochloraz are dependent on timing of sampling. Aquat Toxicol. 2016;175:154-9 pubmed publisher
    ..Correlations among parameters in samples collected at the two times indicated the effects might be due to different concentrations of E2 in plasma due to exposure to PCZ. ..
  4. Kwon B, Ha N, Jung J, Kim P, Kho Y, Choi K, et al. Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio). Bull Environ Contam Toxicol. 2016;96:341-6 pubmed publisher
    ..The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring. ..
  5. Cortés Campos C, Letelier J, Ceriani R, Whitlock K. Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons. Biol Open. 2015;4:1077-86 pubmed publisher
    ..Thus, we demonstrated for the first time that neurospheres can be derived from the hypothalamus of the adult zebrafish and that these neural progenitors are capable of producing GnRH containing neurons. ..
  6. Collard H, Ji K, Lee S, Liu X, Kang S, Kho Y, et al. Toxicity and endocrine disruption in zebrafish (Danio rerio) and two freshwater invertebrates (Daphnia magna and Moina macrocopa) after chronic exposure to mefenamic acid. Ecotoxicol Environ Saf. 2013;94:80-6 pubmed publisher
    ..However, the effective concentrations are orders of magnitude greater than those occurring in the ambient aquatic environment. ..
  7. Ji K, Liu X, Lee S, Kang S, Kho Y, Giesy J, et al. Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish. J Hazard Mater. 2013;254-255:242-51 pubmed publisher
    ..The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring. ..
  8. Flanagan C, Chen C, Coetsee M, Mamputha S, Whitlock K, Bredenkamp N, et al. Expression, structure, function, and evolution of gonadotropin-releasing hormone (GnRH) receptors GnRH-R1SHS and GnRH-R2PEY in the teleost, Astatotilapia burtoni. Endocrinology. 2007;148:5060-71 pubmed
    ..Our results suggest that different duplicated GnRH receptor genes have been selected to regulate reproduction in different vertebrate lineages. ..