gng2

Summary

Gene Symbol: gng2
Description: guanine nucleotide binding protein (G protein), gamma 2
Alias: zgc:110302, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, guanine nucleotide-binding protein gamma 2
Species: zebrafish

Top Publications

  1. Leung T, Chen H, Stauffer A, Giger K, Sinha S, Horstick E, et al. Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis. Blood. 2006;108:160-6 pubmed
    ..Here, we show that targeted knockdown of the G protein gng2 gene (Ggamma2) blocks the normal angiogenic process in developing zebrafish embryos...
  2. Mulligan T, Blaser H, Raz E, Farber S. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cell Signal. 2010;22:221-33 pubmed publisher
  3. Aoki M, Segawa H, Naito M, Okamoto H. Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochem Biophys Res Commun. 2014;445:357-62 pubmed publisher
    ..They are not reported the involvement of axonal extension or their functions in neural cells. Finally, knockdown of these genes suggested their direct actual involvement in the extension of peripheral axons in sensory neurons. ..
  4. Hippe H, Wolf N, Abu Taha I, Mehringer R, Just S, Lutz S, et al. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 2009;106:16269-74 pubmed publisher
    ..Thus, our results suggest a role for the interaction of NDPK B with Gbetagamma dimers and caveolins in regulating membranous G protein content and maintaining normal G protein function in vivo. ..
  5. Xu H, Kardash E, Chen S, Raz E, Lin F. G?? signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development. 2012;139:57-62 pubmed publisher
    ..Our results indicate that during PGC migration in vivo, G?? signaling regulates Rac activity to control cell polarity, which is required for the responsiveness to chemokine signaling. ..