Gene Symbol: gnb1a
Description: guanine nucleotide binding protein (G protein), beta polypeptide 1a
Alias: gnb1, wu:fb50b09, wu:fj94h04, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, guanine nucleotide binding protein (G protein), beta polypeptide 1, transducin beta chain 1
Mulligan T, Blaser H, Raz E, Farber S. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cell Signal. 2010;22:221-33 pubmed publisher
Xu H, Kardash E, Chen S, Raz E, Lin F. G?? signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development. 2012;139:57-62 pubmed publisher
..Our results indicate that during PGC migration in vivo, G?? signaling regulates Rac activity to control cell polarity, which is required for the responsiveness to chemokine signaling. ..
Hippe H, Wolf N, Abu Taha I, Mehringer R, Just S, Lutz S, et al
. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 2009;106:16269-74 pubmed publisher
..Thus, our results suggest a role for the interaction of NDPK B with Gbetagamma dimers and caveolins in regulating membranous G protein content and maintaining normal G protein function in vivo. ..
Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014;385:316-27 pubmed publisher
..Collectively, our data indicate that G?1 controls migration of the pLLP, likely by acting downstream of the Cxcl12a/Cxcr4b signaling. This study also provides compelling evidence for functional specificity among G? isoforms in vivo. ..
Liu F, Chen J, Yu S, Raghupathy R, Liu X, Qin Y, et al
. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet. 2015;24:4648-59 pubmed publisher
..leads to decreased protein levels and abnormal retinal localizations of GRK1 and rod transducin subunits (GNAT1 and GNB1) in zebrafish...
Gebriel M, Prabhudesai S, Uleberg K, Larssen E, Piston D, Bjørnstad A, et al
. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. J Neurosci Res. 2014;92:104-15 pubmed publisher
Ferreira T, Wilson S, Choi Y, Risso D, Dudoit S, Speed T, et al
. Silencing of odorant receptor genes by G protein ?? signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Neuron. 2014;81:847-59 pubmed publisher
..These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. ..
Lagman D, Callado PÃ©rez A, FranzÃ©n I, Larhammar D, Abalo X. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. PLoS ONE. 2015;10:e0121330 pubmed publisher
..We have found that gnb1a and gnb1b are co-expressed at different levels in rods; gnb3a and gnb3b have undergone compartmentalisation ..
Lin C, Taggart A, Lim K, Cygan K, Ferraris L, Creton R, et al
. RNA structure replaces the need for U2AF2 in splicing. Genome Res. 2016;26:12-23 pubmed publisher
..While largely lost from land dwelling vertebrates, this class of introns is found in 10% of all zebrafish genes. ..