gnb1a

Summary

Gene Symbol: gnb1a
Description: guanine nucleotide binding protein (G protein), beta polypeptide 1a
Alias: gnb1, wu:fb50b09, wu:fj94h04, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, guanine nucleotide binding protein (G protein), beta polypeptide 1, transducin beta chain 1
Species: zebrafish
Products:     gnb1a

Top Publications

  1. Mulligan T, Blaser H, Raz E, Farber S. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cell Signal. 2010;22:221-33 pubmed publisher
  2. Xu H, Kardash E, Chen S, Raz E, Lin F. G?? signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development. 2012;139:57-62 pubmed publisher
    ..Our results indicate that during PGC migration in vivo, G?? signaling regulates Rac activity to control cell polarity, which is required for the responsiveness to chemokine signaling. ..
  3. Hippe H, Wolf N, Abu Taha I, Mehringer R, Just S, Lutz S, et al. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 2009;106:16269-74 pubmed publisher
    ..Thus, our results suggest a role for the interaction of NDPK B with Gbetagamma dimers and caveolins in regulating membranous G protein content and maintaining normal G protein function in vivo. ..
  4. Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014;385:316-27 pubmed publisher
    ..Collectively, our data indicate that G?1 controls migration of the pLLP, likely by acting downstream of the Cxcl12a/Cxcr4b signaling. This study also provides compelling evidence for functional specificity among G? isoforms in vivo. ..
  5. Liu F, Chen J, Yu S, Raghupathy R, Liu X, Qin Y, et al. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet. 2015;24:4648-59 pubmed publisher
    ..leads to decreased protein levels and abnormal retinal localizations of GRK1 and rod transducin subunits (GNAT1 and GNB1) in zebrafish...
  6. Gebriel M, Prabhudesai S, Uleberg K, Larssen E, Piston D, Bjørnstad A, et al. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. J Neurosci Res. 2014;92:104-15 pubmed publisher
  7. Ferreira T, Wilson S, Choi Y, Risso D, Dudoit S, Speed T, et al. Silencing of odorant receptor genes by G protein ?? signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Neuron. 2014;81:847-59 pubmed publisher
    ..These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. ..
  8. Lagman D, Callado Pérez A, Franzén I, Larhammar D, Abalo X. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. PLoS ONE. 2015;10:e0121330 pubmed publisher
    ..We have found that gnb1a and gnb1b are co-expressed at different levels in rods; gnb3a and gnb3b have undergone compartmentalisation ..
  9. Lin C, Taggart A, Lim K, Cygan K, Ferraris L, Creton R, et al. RNA structure replaces the need for U2AF2 in splicing. Genome Res. 2016;26:12-23 pubmed publisher
    ..While largely lost from land dwelling vertebrates, this class of introns is found in 10% of all zebrafish genes. ..

More Information

Publications12

  1. Lu Z, Hu X, Liu F, Soares D, Liu X, Yu S, et al. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep. 2017;7:46098 pubmed publisher
  2. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
    ..We conclude that CERKL deficiency in zebrafish may cause rod-cone dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associated with down-regulation of the expression of MERTK. ..
  3. Ke W, Ye D, Mersch K, Xu H, Chen S, Lin F. G?1 is required for neutrophil migration in zebrafish. Dev Biol. 2017;428:135-147 pubmed publisher
    ..Collectively, our data indicate that G?1 signaling controls proper neutrophil migration by activating PI3K and modulating actin dynamics. Moreover, they illustrate a role for a specific G? isoform in chemotaxis in vivo. ..