Gene Symbol: gnas
Description: GNAS complex locus
Alias: guanine nucleotide-binding protein G(s) subunit alpha, Galpha s
Oka Y, Saraiva L, Kwan Y, Korsching S. The fifth class of Galpha proteins. Proc Natl Acad Sci U S A. 2009;106:1484-9 pubmed publisher
..The discovery of this fifth class of Galpha proteins changes our understanding of G protein evolution. ..
Hippe H, Wolf N, Abu Taha I, Mehringer R, Just S, Lutz S, et al
. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A. 2009;106:16269-74 pubmed publisher
..Thus, our results suggest a role for the interaction of NDPK B with Gbetagamma dimers and caveolins in regulating membranous G protein content and maintaining normal G protein function in vivo. ..
Cal L, Megias M, Cerdá Reverter J, Postlethwait J, Braasch I, Rotllant J. BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. J Exp Zool B Mol Dev Evol. 2017;328:697-708 pubmed publisher
..These experiments provide evidence that the mechanism leading to an environmentally important pigment pattern was likely in place before the origin of teleosts. ..
Oka Y, Korsching S. Shared and unique G alpha proteins in the zebrafish versus mammalian senses of taste and smell. Chem Senses. 2011;36:357-65 pubmed publisher
..Our results show general similarity to the mammalian situation but also clear-cut differences and as such are essential for using the zebrafish model system to study chemosensory perception...
Muto A, Taylor M, Suzawa M, Korenbrot J, Baier H. Glucocorticoid receptor activity regulates light adaptation in the zebrafish retina. Front Neural Circuits. 2013;7:145 pubmed publisher
..We suggest that GR controls a gene network required for visual adaptation in the zebrafish retina and potentially integrates neuroendocrine and sensory responses to environmental changes. ..
Ferreira T, Wilson S, Choi Y, Risso D, Dudoit S, Speed T, et al
. Silencing of odorant receptor genes by G protein ?? signaling ensures the expression of one odorant receptor per olfactory sensory neuron. Neuron. 2014;81:847-59 pubmed publisher
..These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. ..