Gene Symbol: glypican 3
Description: glypican 3
De Cat B, Muyldermans S, Coomans C, Degeest G, Vanderschueren B, Creemers J, et al
. Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol. 2003;163:625-35 pubmed
Flowers G, Topczewska J, Topczewski J. A zebrafish Notum homolog specifically blocks the Wnt/?-catenin signaling pathway. Development. 2012;139:2416-25 pubmed publisher
..Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity (PCP) pathway. Our results suggest a surprising specific role of Notum in the developing vertebrate embryo. ..
Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al
. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al
. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
..Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA. ..
Gupta M, Brand M. Identification and expression analysis of zebrafish glypicans during embryonic development. PLoS ONE. 2013;8:e80824 pubmed publisher
..Existence of multiple glypican orthologs in fish with diverse expression pattern suggests highly specialized and/or redundant function of these genes during embryonic development. ..