Gene Symbol: glra4a
Description: glycine receptor, alpha 4a
Alias: [a]Z2, glra2, zgc:113093, glycine receptor subunit alpha-4, GlyR [a]Z2, glyR alpha, glycine receptor, alpha 2
Imboden M, de Saint Jan D, Leulier F, Korn H, Goblet C, Bregestovski P. Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit. Neuroscience. 2001;103:799-810 pubmed
..This report contributes to the characterization of the diversity of glycine receptor isoforms in vertebrates. ..
McDearmid J, Liao M, Drapeau P. Glycine receptors regulate interneuron differentiation during spinal network development. Proc Natl Acad Sci U S A. 2006;103:9679-84 pubmed
..These data provide evidence that glycine receptors, in addition to their role in neurotransmission, regulate interneuron differentiation during development of this central neural network. ..
Hirata H, Carta E, Yamanaka I, Harvey R, Kuwada J. Defective glycinergic synaptic transmission in zebrafish motility mutants. Front Mol Neurosci. 2009;2:26 pubmed publisher
..We review current knowledge regarding zebrafish 'accordion' and 'twitch-once' mutants, including beo and sho, and report the identification of a new alpha2 subunit that revises the phylogeny of zebrafish GlyRs. ..
Van Hellemont R, Blomme T, Van de Peer Y, Marchal K. Divergence of regulatory sequences in duplicated fish genes. Genome Dyn. 2007;3:81-100 pubmed publisher
..In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates. ..
Hirata H, Ogino K, Yamada K, Leacock S, Harvey R. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci. 2013;33:14638-44 pubmed publisher
..To our knowledge, this is the first identification of pathologically relevant substrates for an RNA helicase...
Ganser L, Yan Q, James V, Kozol R, Topf M, Harvey R, et al
. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139-51 pubmed publisher
..Based on our findings, future studies that aim to model candidate startle disease genes in zebrafish should include measures of spasticity and synaptic development...
Samarut E, Bekri A, Drapeau P. Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Front Mol Neurosci. 2016;9:22 pubmed publisher
Samarut E, Lissouba A, Drapeau P. A simplified method for identifying early CRISPR-induced indels in zebrafish embryos using High Resolution Melting analysis. BMC Genomics. 2016;17:547 pubmed publisher