glra1

Summary

Gene Symbol: glra1
Description: glycine receptor, alpha 1
Alias: [a]Z1, glycine receptor subunit alphaZ1, GlyR [a]Z1, glycine receptor, alphaZ1 subunit
Species: zebrafish
Products:     glra1

Top Publications

  1. Hirata H, Saint Amant L, Downes G, Cui W, Zhou W, Granato M, et al. Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. Proc Natl Acad Sci U S A. 2005;102:8345-50 pubmed
    ..Because GlyR mutations in humans lead to hyperekplexia, a motor disorder characterized by startle responses, the zebrafish beo mutant should be a useful animal model for this condition. ..
  2. McDearmid J, Liao M, Drapeau P. Glycine receptors regulate interneuron differentiation during spinal network development. Proc Natl Acad Sci U S A. 2006;103:9679-84 pubmed
    ..These data provide evidence that glycine receptors, in addition to their role in neurotransmission, regulate interneuron differentiation during development of this central neural network. ..
  3. Roy N, Arpie B, Lugo J, Linney E, Levin E, Cerutti D. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. 2012;34:587-91 pubmed publisher
    ..Taken together, these data show that a short embryonic exposure to a neurotoxicant can alter development of neural synapses and lead to changes in adult behavior. ..
  4. Du J, Lü W, Wu S, Cheng Y, Gouaux E. Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature. 2015;526:224-9 pubmed publisher
    ..These structures illuminate the GlyR mechanism and define a rubric to interpret structures of Cys-loop receptors. ..
  5. Mongeon R, Gleason M, Masino M, Fetcho J, Mandel G, Brehm P, et al. Synaptic homeostasis in a zebrafish glial glycine transporter mutant. J Neurophysiol. 2008;100:1716-23 pubmed publisher
    ..These results suggest that increased CNS glycine tolerance and reduced glycine receptor expression in GlyT1 mutants reflect compensatory mechanisms for functional recovery from excess nervous system inhibition. ..
  6. Van Hellemont R, Blomme T, Van de Peer Y, Marchal K. Divergence of regulatory sequences in duplicated fish genes. Genome Dyn. 2007;3:81-100 pubmed publisher
    ..In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates. ..
  7. Ganser L, Yan Q, James V, Kozol R, Topf M, Harvey R, et al. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139-51 pubmed publisher
    ..Mutations known to cause startle disease have been identified in glycine receptor subunit (GLRA1 and GLRB) and glycine transporter (SLC6A5) genes, which serve essential functions at glycinergic synapses...
  8. David Watine B, Goblet C, de Saint Jan D, Fucile S, Devignot V, Bregestovski P, et al. Cloning, expression and electrophysiological characterization of glycine receptor alpha subunit from zebrafish. Neuroscience. 1999;90:303-17 pubmed
  9. Imboden M, de Saint Jan D, Leulier F, Korn H, Goblet C, Bregestovski P. Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit. Neuroscience. 2001;103:799-810 pubmed
    ..This report contributes to the characterization of the diversity of glycine receptor isoforms in vertebrates. ..

More Information

Publications14

  1. Hirata H, Ogino K, Yamada K, Leacock S, Harvey R. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci. 2013;33:14638-44 pubmed publisher
    ..To our knowledge, this is the first identification of pathologically relevant substrates for an RNA helicase...
  2. Fucile S, de Saint Jan D, David Watine B, Korn H, Bregestovski P. Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor. J Physiol. 1999;517 ( Pt 2):369-83 pubmed
    ..7. Our data demonstrate that the kinetics of glycine and GABA interactions with alphaZ1 are different and that they determine the properties of these neurotransmitter actions on the GlyR. ..
  3. Ruuskanen J, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan Y, et al. Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol Biol Evol. 2004;21:14-28 pubmed
  4. Devignot V, Prado De Carvalho L, Bregestovski P, Goblet C. A novel glycine receptor alpha Z1 subunit variant in the zebrafish brain. Neuroscience. 2003;122:449-57 pubmed
    ..This report contributes to the characterization of the diversity of glycine receptor isoforms in zebrafish and emphasizes the common mechanism used among vertebrates for creating GlyR variety and specificity. ..
  5. David Watine B, Shorte S, Fucile S, de Saint Jan D, Korn H, Bregestovski P. Functional integrity of green fluorescent protein conjugated glycine receptor channels. Neuropharmacology. 1999;38:785-92 pubmed
    ..Overall, the preservation in alphaZ1-GFPs of the wild type receptor functional properties makes it a promising new tool for further in situ investigations of GlyR expression, distribution and function. ..