Gene Symbol: ghrb
Description: growth hormone receptor b
Alias: ghr.b, growth hormone receptor b
Species: zebrafish

Top Publications

  1. Di Prinzio C, Botta P, Barriga E, Ríos E, Reyes A, Arranz S. Growth hormone receptors in zebrafish (Danio rerio): adult and embryonic expression patterns. Gene Expr Patterns. 2010;10:214-25 pubmed publisher
    ..In the present work, we characterized the complete cDNA sequences of zebrafish GHRs, ghra and ghrb, and their gene structures...
  2. Schüttler A, Reiche K, Altenburger R, Busch W. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Toxicol Sci. 2017;157:291-304 pubmed publisher
    ..In future, improved time- and concentration-resolved experiments should offer better understanding of stress response patterns and access to mechanistic information. ..
  3. Chen M, Huang X, Yuen D, Cheng C. A study on the functional interaction between the GH/PRL family of polypeptides with their receptors in zebrafish: Evidence against GHR1 being the receptor for somatolactin. Mol Cell Endocrinol. 2011;337:114-21 pubmed publisher
    ..The zebrafish SLs, found to be biologically active in another assay, were found to be ineffective in interacting with the zebrafish GHRs and PRLRs. Our data argue against the hypothesis that GHR1 is the SL receptor. ..
  4. Amaral I, Johnston I. Experimental selection for body size at age modifies early life-history traits and muscle gene expression in adult zebrafish. J Exp Biol. 2012;215:3895-904 pubmed publisher
    ..For example, igf2 receptor transcript abundance was higher and igbp1a/b transcript abundance was lower in the L- than in the S-lineage, consistent with an effect of selection on insulin-like growth factor signalling. ..
  5. Jing J, Xiong S, Li Z, Wu J, Zhou L, Gui J, et al. A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish. Sci Rep. 2015;5:15906 pubmed publisher members are critical regulators of embryo size by targeting several GH/IGF axis genes, including GH, GHRa, GHRb and IGF2a...
  6. Nornberg B, Almeida D, Figueiredo M, Marins L. GH indirectly enhances the regeneration of transgenic zebrafish fins through IGF2a and IGF2b. Transgenic Res. 2016;25:743-9 pubmed publisher
    ..Transgenic fish also presented a decrease in gene expression of the GH receptor (ghrb), in opposition to the increased expression of the IGF1 receptors (igf1ra and igf1rb)...
  7. Li M, Gao Z, Ji D, Zhang S. Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology. 2014;155:4818-30 pubmed publisher
    ..These data collectively suggest that a vertebrate-like neuroendocrine axis setting has already emerged in amphioxus, which lays a foundation for subsequent formation of hypothalamic-pituitary system in vertebrates. ..
  8. Figueiredo M, Boyle R, Sandrini J, Varela A, Marins L. High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. J Mol Endocrinol. 2016;56:47-54 pubmed publisher
    ..In addition, the results presented here highlight the possibility that these membrane proteins may be involved more directly than previously thought in the control of genes related to cell growth and proliferation. ..
  9. Yu L, Jia Y, Su G, Sun Y, Letcher R, Giesy J, et al. Parental transfer of tris(1,3-dichloro-2-propyl) phosphate and transgenerational inhibition of growth of zebrafish exposed to environmentally relevant concentrations. Environ Pollut. 2017;220:196-203 pubmed publisher
    ..This study provides the first known evidence that exposure of zebrafish to environmentally relevant concentrations of TDCIPP during development can inhibit growth of offspring, which were not exposed directly to TDCIPP. ..

More Information


  1. Hou J, Su Y, Lin W, Guo H, Xie P, Chen J, et al. Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish. Ecotoxicol Environ Saf. 2017;139:27-35 pubmed publisher
    ..Our results provide evidence that MC-LR at environmentally relevant concentrations is able to induce impairments on fish gonadal development. ..
  2. Tsai T, Lu J, Choo S, Yeh S, Tang R, Lee H, et al. The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos. J Biomed Sci. 2012;19:63 pubmed publisher
    ..of downstream mediators in the GH and insulin-like growth factor (IGF)-1 pathway, including igf1, ghra, and ghrb, and signal transductors (erk1, akt2), and eventually to correct dysmorphogenesis in various organs including the ..
  3. Besseau L, Fuentes M, Sauzet S, Beauchaud M, Chatain B, Coves D, et al. Somatotropic axis genes are expressed before pituitary onset during zebrafish and sea bass development. Gen Comp Endocrinol. 2013;194:133-41 pubmed publisher
  4. Zhou R, Yu S, Ge W. Expression and functional characterization of intrafollicular GH-IGF system in the zebrafish ovary. Gen Comp Endocrinol. 2016;232:32-42 pubmed publisher
    ..All key members of this axis including growth hormone (GH, gh), GH receptors (ghra and ghrb), insulin-like growth factors (IGFs, igf1, igf2 and igf3) and IGF receptors (igf1ra and igf1rb) were detected in ..
  5. Fukamachi S, Meyer A. Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues. J Mol Evol. 2007;65:359-72 pubmed
    ..On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD. ..
  6. Biga P, Meyer J. Growth hormone differentially regulates growth and growth-related gene expression in closely related fish species. Comp Biochem Physiol A Mol Integr Physiol. 2009;154:465-73 pubmed publisher
    ..These results further support the role that the zebrafish and giant danio can play important model organisms for determinate and indeterminate growth. ..
  7. Palstra A, Tudorache C, Rovira M, Brittijn S, Burgerhout E, van den Thillart G, et al. Establishing zebrafish as a novel exercise model: swimming economy, swimming-enhanced growth and muscle growth marker gene expression. PLoS ONE. 2010;5:e14483 pubmed publisher
    ..marker genes revealed clear regulatory roles in relation to swimming-enhanced growth for genes such as growth hormone receptor b (ghrb), insulin-like growth factor 1 receptor a (igf1ra), troponin C (stnnc), slow myosin heavy chain 1 (..