Gene Symbol: gfra1a
Description: gdnf family receptor alpha 1a
Alias: gfralpha1a, zgc:110129, gdnf family receptor alpha 1a
Species: zebrafish

Top Publications

  1. Kl ver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, et al. Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn. 2007;236:271-81 pubmed publisher
    ..Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes...
  2. Facello B, Castaldo L, De Martino L, Lucini C. Glial cell line-derived neurotrophic factor in Purkinje cells of adult zebrafish: an autocrine mode of action?. Neurosci Lett. 2009;465:133-7 pubmed publisher
    ..These results demonstrated the expression of the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of GDNF in Purkinje cells. ..
  3. Lucini C, Carla L, Facello B, Bruna F, Maruccio L, Lucianna M, et al. Distribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish. J Anat. 2010;217:174-85 pubmed publisher
    ..In zebrafish (Danio rerio) embryos, the expression of the GFRalpha1a and GFRalpha1b genes has been shown in primary motor neurons, the kidney, and the enteric nervous system...
  4. Shepherd I, Beattie C, Raible D. Functional analysis of zebrafish GDNF. Dev Biol. 2001;231:420-35 pubmed
    ..We also depleted GDNF protein in zebrafish embryos using morpholino antisense oligos and found that GDNF protein is critical for the development of the zebrafish ENS but appears dispensable for the development of the kidney and PMN. ..
  5. Shepherd I, Pietsch J, Elworthy S, Kelsh R, Raible D. Roles for GFRalpha1 receptors in zebrafish enteric nervous system development. Development. 2004;131:241-9 pubmed
    ..Both gfra1a and gfra1b as well as ret are expressed at this time, while gfra2 expression, the receptor component that binds ..
  6. Schuster K, Dambly Chaudiere C, Ghysen A. Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish. Proc Natl Acad Sci U S A. 2010;107:19531-6 pubmed publisher
    ..We conclude that GDNF is a major determinant of directed neuritic growth and of target finding in this system, and we propose that GDNF acts by promoting local neurite outgrowth. ..
  7. Goodman K, Kjær S, Beuron F, Knowles P, Nawrotek A, Burns E, et al. RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Rep. 2014;8:1894-1904 pubmed publisher
    ..Coupling of these CRD-mediated interactions suggests models for ligand-induced RET activation and ligand-independent oncogenic deregulation. ..
  8. Hätinen T, Holm L, Airaksinen M. Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs. Mol Cell Neurosci. 2007;34:155-67 pubmed
    ..Evolutionary trace analysis and protein structure homology modeling points at GDNF as the endogenous ligand of frog GFRalpha2. ..
  9. Mosimann C, Panáková D, Werdich A, Musso G, Burger A, Lawson K, et al. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015;6:8146 pubmed publisher
    ..Our data establish that the transcriptional program driving cardiac septation regulates physiologic ventricle partitioning, which successively provides mechanical advantages of sequential contraction. ..

More Information


  1. Saarenpää T, Kogan K, Sidorova Y, Mahato A, Tascón I, Kaljunen H, et al. Zebrafish GDNF and its co-receptor GFR?1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PLoS ONE. 2017;12:e0176166 pubmed publisher
    ..coli-produced human proteins. These results contradict previous studies suggesting that mammalian GFR?1 and GDNF cannot bind and activate non-mammalian RET and vice versa. ..