gck

Summary

Gene Symbol: gck
Description: glucokinase (hexokinase 4)
Alias: fb57f10, glk, hex4, wu:fb57f10, zgc:153643, glucokinase, glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
Species: zebrafish

Top Publications

  1. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). J Exp Biol. 2014;217:1139-49 pubmed publisher
    ..Overall, supplementation of egg yolk with high glucose levels had little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish. ..
  2. Drew R, Rodnick K, Settles M, Wacyk J, Churchill E, Powell M, et al. Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio). Physiol Genomics. 2008;35:283-95 pubmed publisher
  3. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Br J Nutr. 2015;113:403-13 pubmed publisher
    ..Globally, our data suggest that glucose stimulus at embryo stage has the potential to alter particular steps of glucose metabolism in zebrafish juveniles. ..
  4. Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
    ..These results indicated that exposure to IMZ could cause gut microbiota dysbiosis and metabolic disorders in adult zebrafish. ..
  5. González Alvarez R, Ortega Cuellar D, Hernandez Mendoza A, Moreno Arriola E, Villaseñor Mendoza K, Gálvez Mariscal A, et al. The hexokinase gene family in the zebrafish: structure, expression, functional and phylogenetic analysis. Comp Biochem Physiol B Biochem Mol Biol. 2009;152:189-95 pubmed publisher
    ..muscle and brain isoforms are fusion products of the ancestral gene, their amino halves having separated before than their carboxy ones, followed by the fusion event, whereas fish and mammalian glucokinase genes remained unduplicated.
  6. Seiliez I, Médale F, Aguirre P, Larquier M, Lanneretonne L, Alami Durante H, et al. Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 2013;10:237-48 pubmed publisher
    ..Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies. ..
  7. Fang L, Liang X, Zhou Y, Guo X, He Y, Yi T, et al. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Br J Nutr. 2014;111:808-18 pubmed publisher
    ..The mRNA levels and enzyme activities of glucokinase, pyruvate kinase, ?-amylase and sodium-dependent glucose co-transporter 1 were up-regulated in the first-..
  8. Kumar M, Rowley S, Fulton R, Dinday M, Baraban S, Patel M. Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. Eneuro. 2016;3: pubmed publisher
    ..Our findings in scn1Lab mutant zebrafish suggest that glucose and mitochondrial hypometabolism contribute to the pathophysiology of DS. ..
  9. Karanth S, Zinkhan E, Hill J, Yost H, Schlegel A. FOXN3 Regulates Hepatic Glucose Utilization. Cell Rep. 2016;15:2745-55 pubmed publisher
    ..Human FOXN3 binds DNA sequences in the human MYC and zebrafish mycb loci. We conclude that the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose. ..

More Information

Publications15

  1. Dai Z, Wang H, Jin X, Wang H, He J, Liu M, et al. Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015;308:E849-59 pubmed publisher
  2. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  3. Marín Juez R, Marass M, Gauvrit S, Rossi A, Lai S, Materna S, et al. Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2016;113:11237-11242 pubmed
    ..Our work also paves the way for future studies designed to understand the molecular mechanisms that regulate fast revascularization. ..
  4. Zhao F, Jiang G, Wei P, Wang H, Ru S. Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2018;147:794-802 pubmed publisher
  5. Hostelley T, Nesmith J, Zaghloul N. Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish. J Vis Exp. 2017;: pubmed publisher
    ..These protocols can be used for comparative analysis of control and experimental sets of zebrafish to identify novel gene expression changes, and provide molecular insight into phenotypes of interest. ..
  6. Opazo R, Fuenzalida K, Plaza Parrochia F, Romero J. Performance of Debaryomyces hansenii as a Diet for Rotifers for Feeding Zebrafish Larvae. Zebrafish. 2017;14:187-194 pubmed publisher
    ..The gene responses observed in this work open up the opportunity to study the effect of omega-3 supply on growth regulation in zebrafish. ..