gch2

Summary

Gene Symbol: gch2
Description: GTP cyclohydrolase 2
Alias: fb51g02, gch, gch1b, wu:fb51g02, GTP cyclohydrolase 1
Species: zebrafish

Top Publications

  1. Knight R, Nair S, Nelson S, Afshar A, Javidan Y, Geisler R, et al. lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development. 2003;130:5755-68 pubmed
    ..These studies demonstrate that low is required for early steps in neural crest development and suggest that tfap2a is essential for the survival of a subset of neural crest derivatives. ..
  2. Minchin J, Hughes S. Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest. Dev Biol. 2008;317:508-22 pubmed publisher
    ..Therefore, Pax3 in zebrafish is required for specification of two specific lineages of neural crest, xanthophores and enteric neurons. ..
  3. Piloto S, Schilling T. Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Development. 2010;137:1981-90 pubmed publisher
    ..Similar processes probably occur in other cell types in which Wnt signaling promotes migration. ..
  4. Quigley I, Manuel J, Roberts R, Nuckels R, Herrington E, MacDonald E, et al. Evolutionary diversification of pigment pattern in Danio fishes: differential fms dependence and stripe loss in D. albolineatus. Development. 2005;132:89-104 pubmed
    ..Together, these data suggest evolutionary changes in the fms pathway or fms requirements, and identify changes in cellular interactions as a likely mechanism of evolutionary change in Danio pigment patterns...
  5. Sedykh I, Yoon B, Roberson L, Moskvin O, Dewey C, Grinblat Y. Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis. Dev Biol. 2017;429:92-104 pubmed publisher
    ..Collectively, these data establish zic2 mutant zebrafish as a powerful new genetic model for in-depth dissection of cell interactions and genetic controls during craniofacial complex development. ..
  6. Svetic V, Hollway G, Elworthy S, Chipperfield T, Davison C, Adams R, et al. Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants. Development. 2007;134:1011-22 pubmed
    ..We thus identify Sdf1 as a key molecule in pigment pattern formation, adding to the growing inventory of its roles in embryonic development...
  7. Tuttle A, Hoffman T, Schilling T. Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration. PLoS Biol. 2014;12:e1001852 pubmed publisher
    ..Our results suggest that different v-ATPases and associated proteins may play cell-type-specific functions in intracellular trafficking in many contexts...
  8. Ng A, Uribe R, Yieh L, Nuckels R, Gross J. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Development. 2009;136:2601-11 pubmed publisher
  9. Greenhill E, Rocco A, Vibert L, Nikaido M, Kelsh R. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. PLoS Genet. 2011;7:e1002265 pubmed publisher
    ..More generally, this novel approach to understanding melanocyte differentiation provides a basis for systematic modelling of differentiation in this and other cell-types. ..

More Information

Publications18

  1. Zhang T, Zhou X, Ma X, Liu J. Mechanisms of cadmium-caused eye hypoplasia and hypopigmentation in zebrafish embryos. Aquat Toxicol. 2015;167:68-76 pubmed publisher
    ..Moreover, we found that compounds BIO or RA could neutralize the toxic effects of Cd. ..
  2. Montero Balaguer M, Lang M, Sachdev S, Knappmeyer C, Stewart R, De La Guardia A, et al. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Dev Dyn. 2006;235:3199-212 pubmed
    ..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors. ..
  3. Lacosta A, Canudas J, Gonzalez C, Muniesa P, Sarasa M, Dominguez L. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during zebrafish development. Int J Dev Biol. 2007;51:327-31 pubmed
    ..Finally, during the larva to adult transition, we show that pigment stem cells recapitulate the expression of Pax7. ..
  4. Nguyen C, Langenbacher A, Hsieh M, Chen J. The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish. Dev Biol. 2010;341:167-75 pubmed publisher
    ..In addition, the expression levels of markers for neural crest-derived cells such as crestin, gch2, dct and mitfa are greatly reduced in leo1(LA1186) mutants, indicating a requirement for Leo1 in maintaining the ..
  5. Lee Y, Nachtrab G, Klinsawat P, Hami D, Poss K. Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Dis Model Mech. 2010;3:496-503 pubmed publisher
  6. Das A, Crump J. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002710 pubmed publisher
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  7. Teslaa J, Keller A, Nyholm M, Grinblat Y. Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development. Dev Biol. 2013;380:73-86 pubmed publisher
  8. Han B, Li W, Chen Z, Xu Q, Luo J, Shi Y, et al. Variation of DNA Methylome of Zebrafish Cells under Cold Pressure. PLoS ONE. 2016;11:e0160358 pubmed publisher
    ..Our data indicate the involvement of DNA methylation in cellular response to cold pressure, and put a new insight into the genome-wide epigenetic regulation under cold pressure. ..
  9. Nord H, Dennhag N, Muck J, Von Hofsten J. Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos. Mol Biol Cell. 2016;27:1853-62 pubmed publisher
    ..In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells. ..