gadd45aa

Summary

Gene Symbol: gadd45aa
Description: growth arrest and DNA-damage-inducible, alpha, a
Alias: gadd45al, zgc:65993, zgc:77480, growth arrest and DNA damage-inducible protein GADD45 alpha, gadd45alpha, growth arrest and DNA damage 45 alpha, growth arrest and DNA-damage-inducible, alpha like
Species: zebrafish
Products:     gadd45aa

Top Publications

  1. Rai K, Huggins I, James S, Karpf A, Jones D, Cairns B. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 2008;135:1201-12 pubmed publisher
    ..Our results provide evidence for a coupled mechanism of 5-meC demethylation, whereby AID deaminates 5-meC, followed by thymine base excision by Mbd4, promoted by Gadd45. ..
  2. Lin H, Zhou Z, Zhong W, Huang P, Ma N, Zhang Y, et al. Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae. Oncol Rep. 2017;38:2877-2884 pubmed publisher
    ..The present study showed that naringenin inhibited alcohol-induced liver steatosis and injury in zebrafish larvae by reducing apoptosis and DNA damage and by harmonizing alcohol and lipid metabolism. ..
  3. Zhang J, Sun P, Kong T, Yang F, Guan W. Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquat Toxicol. 2016;170:208-215 pubmed publisher
    ..In short, TBT can produce multiple and complex alterations in transcriptional activity of lipid metabolism and cell damage, which provides potential molecular evidence of TBT on hepatic steatosis. ..
  4. Usenko C, Hopkins D, Trumble S, Bruce E. Hydroxylated PBDEs induce developmental arrest in zebrafish. Toxicol Appl Pharmacol. 2012;262:43-51 pubmed publisher
    ..This study suggests that hydroxylated PBDEs disrupt development, and may induce oxidative stress and potentially disrupt the cholinergic system and thyroid hormone homeostasis. ..
  5. Taylor A, Humphries J, White R, Murphey R, BURNS C, Zon L. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012;40:228-237.e5 pubmed publisher
    ..Together, our studies demonstrate a role of p53 in mediating the cellular defects associated with rps29 and establish a role for rps29 and p53 in hematopoietic stem cells and red blood cell development. ..
  6. Wan X, Hu B, Liu J, Feng X, Xiao W. Zebrafish mll gene is essential for hematopoiesis. J Biol Chem. 2011;286:33345-57 pubmed publisher
    ..Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45?a may serve as a potential downstream target for mediating the function of mll in hematopoiesis. ..
  7. Zhao X, Zhao L, Tian T, Zhang Y, Tong J, Zheng X, et al. Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish. J Biol Chem. 2010;285:27924-34 pubmed publisher
    ..Taken together, our findings uncover an essential role of cenph in mitosis and embryonic development and its association with tumor development. ..
  8. Powell C, Elsaeidi F, Goldman D. Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b. J Neurosci. 2012;32:1096-109 pubmed publisher
    ..These data identify an essential role for Apobec proteins during retina and optic nerve regeneration and suggest DNA demethylation may underlie the reprogramming of cells to mount a regenerative response. ..
  9. Lim C, Chong S, Jiang Y. Udu deficiency activates DNA damage checkpoint. Mol Biol Cell. 2009;20:4183-93 pubmed publisher
    ..Furthermore, Udu is colocalized with 5-bromo-2'-deoxyuridine and heterochromatin during DNA replication, suggesting a role in maintaining genome integrity. ..

More Information

Publications19

  1. Zheng X, Yang S, Han Y, Zhao X, Zhao L, Tian T, et al. Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. J Biol Chem. 2012;287:38254-64 pubmed publisher
    ..Our findings shed new light on developmental function of Nup107 in vertebrates. ..
  2. Passeri M, Cinaroglu A, Gao C, Sadler K. Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology. 2009;49:443-52 pubmed publisher
    ..Srebp activation is required for steatosis in this model. The tractability of zebrafish genetics provides a valuable tool for dissecting the molecular pathogenesis of acute ALD. ..
  3. Liu Y, Du L, Osato M, Teo E, Qian F, Jin H, et al. The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood. 2007;110:99-106 pubmed
    ..Our study indicates that the Udu protein is very likely to function as a transcription modulator essential for the proliferation and differentiation of erythroid lineage...
  4. Wu S, Tsai P, Chou M, Wang W. Effects of maternal cadmium exposure on female reproductive functions, gamete quality, and offspring development in zebrafish (Danio rerio). Arch Environ Contam Toxicol. 2013;65:521-36 pubmed publisher
    ..These results showed that maternal Cd(2+) exposure influenced the reproduction ability of females and also caused their embryos to develop with abnormal gene expression. ..
  5. Dhliwayo N, Sarras M, Luczkowski E, Mason S, Intine R. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Diabetes. 2014;63:3069-76 pubmed publisher
    ..Remarkably, this inhibition was accompanied by a complete restoration of the tissue regeneration deficit that is also induced by HG. The ultimate goal of this work is to provide potential new avenues for therapeutic discovery. ..
  6. Shimoda N, Hirose K, Kaneto R, Izawa T, Yokoi H, Hashimoto N, et al. No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos. PLoS ONE. 2014;9:e114816 pubmed publisher
    ..Taken together, we concluded that there is currently no evidence to support the proposed roles of AID and MBD4 in active demethylation in zebrafish embryos. ..
  7. Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, et al. Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish. Nucleic Acids Res. 2015;43:9198-213 pubmed publisher
    ..Thus, the methodology used and the regulatory networks uncovered in this study provide a foundation for exploring the mechanisms of cold adaptation in teleosts. ..
  8. Zhao X, Zhang Y, Ni P, Wu Z, Yan Y, Li Y. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. J Biol Chem. 2016;291:402-12 pubmed publisher
    ..Taken together, these results suggest that maternal Prmt6 is essential to early zebrafish development by directly repressing gadd45αa. ..
  9. Song Y, Shi Y, Carland T, Lian S, Sasaki T, Schork N, et al. p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. Proc Natl Acad Sci U S A. 2016;113:8460-5 pubmed publisher
    ..We suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis. ..
  10. Loponte S, Segré C, Senese S, Miccolo C, Santaguida S, Deflorian G, et al. Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Sci Rep. 2016;6:30213 pubmed publisher
    ..Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology. ..