g6pca.1

Summary

Gene Symbol: g6pca.1
Description: glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
Alias: cb822, g6pc, g6pca, zgc:92368, glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1, glucose-6-phosphatase a, catalytic, tandem duplicate 1, glucose-6-phosphatase, catalytic
Species: zebrafish

Top Publications

  1. Zhang K, Zhao Y, Fent K. Occurrence and Ecotoxicological Effects of Free, Conjugated, and Halogenated Steroids Including 17?-Hydroxypregnanolone and Pregnanediol in Swiss Wastewater and Surface Water. Environ Sci Technol. 2017;51:6498-6506 pubmed publisher
    ..Although steroid concentrations are low in Swiss rivers, the possibility of additive effects may be of concern. ..
  2. Furukawa F, Tseng Y, Liu S, Chou Y, Lin C, Sung P, et al. Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes. Int J Biol Sci. 2015;11:712-25 pubmed publisher
    ..The present study provides the first in vivo evidence that acid-induced PEPCK provides glucose for acid-base homeostasis at an individual level, which is supported by rapid pumping of H(+) via V-ATPase at the cellular level. ..
  3. Zhao F, Jiang G, Wei P, Wang H, Ru S. Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2018;147:794-802 pubmed publisher
  4. Joris M, Schloesser M, Baurain D, Hanikenne M, Muller M, Motte P. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic Acids Res. 2017;45:9547-9557 pubmed publisher
    ..Our data contribute to the debate about MO specificity, efficacy and the number of unknown targeted sequences. ..
  5. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  6. Kumar M, Rowley S, Fulton R, Dinday M, Baraban S, Patel M. Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. Eneuro. 2016;3: pubmed publisher
    ..Our findings in scn1Lab mutant zebrafish suggest that glucose and mitochondrial hypometabolism contribute to the pathophysiology of DS. ..
  7. Dai Z, Wang H, Jin X, Wang H, He J, Liu M, et al. Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015;308:E849-59 pubmed publisher
  8. Fang L, Liang X, Zhou Y, Guo X, He Y, Yi T, et al. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Br J Nutr. 2014;111:808-18 pubmed publisher
    ..In conclusion, the present study demonstrates that it is possible to permanently modify carbohydrate digestion, transport and metabolism of adult zebrafish through early nutritional programming. ..
  9. Li M, Dean E, Zhao L, Nicholson W, Powers A, Chen W. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. J Endocrinol. 2015;227:93-103 pubmed publisher
    ..The robust α-cell hyperplasia in gcgra-/-;gcgrb-/- larvae provides a platform to screen for chemical and genetic suppressors, and ultimately to identify the stimulus of α-cell hyperplasia and its signaling mechanism. ..

More Information

Publications17

  1. Kuang X, Liu C, Fang J, Ma W, Zhang J, Cui S. The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS Lett. 2016;590:2076-85 pubmed publisher
  2. Gut P, Baeza Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, et al. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013;9:97-104 pubmed publisher
    ..Thus, using a whole-organism screening strategy, this study has identified new small-molecule activators of fasting metabolism. ..
  3. Wang Y, Wang H, Li M, Gao Z, Zhang S. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. Gen Comp Endocrinol. 2015;214:9-16 pubmed publisher
    ..Collectively, all these provide functional evidences supporting the notion that the digestive diverticulum is the liver homologue playing a key role in maintaining the glucose homeostasis in amphioxus. ..
  4. Sukardi H, Zhang X, Lui E, Ung C, Mathavan S, Gong Z, et al. Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: histological, gene set enrichment and expression analyses. Biochim Biophys Acta. 2012;1820:33-43 pubmed publisher
    ..Our study underscores the potential of using zebrafish model coupled with transcriptomic analysis to capture pharmacological and toxicological or pathological events induced by LXR modulators. ..
  5. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Br J Nutr. 2015;113:403-13 pubmed publisher
    ..Globally, our data suggest that glucose stimulus at embryo stage has the potential to alter particular steps of glucose metabolism in zebrafish juveniles. ..
  6. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). J Exp Biol. 2014;217:1139-49 pubmed publisher
    ..Overall, supplementation of egg yolk with high glucose levels had little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish. ..
  7. Seiliez I, Médale F, Aguirre P, Larquier M, Lanneretonne L, Alami Durante H, et al. Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 2013;10:237-48 pubmed publisher
    ..Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies. ..
  8. Michel M, Page McCaw P, Chen W, Cone R. Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proc Natl Acad Sci U S A. 2016;113:3084-9 pubmed publisher