frzb

Summary

Gene Symbol: frzb
Description: frizzled related protein
Alias: cb291, fzb-1, fzb1, id:ibd5075, ik:tdsubc_2e7, sfrp3, xx:tdsubc_2e7, secreted frizzled-related protein 3
Species: zebrafish
Products:     frzb

Top Publications

  1. Kapsimali M, Caneparo L, Houart C, Wilson S. Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development. 2004;131:5923-33 pubmed
  2. Mo S, Wang L, Li Q, Li J, Li Y, Thannickal V, et al. Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish. Dev Biol. 2010;344:210-23 pubmed publisher
    ..Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin. ..
  3. Tendeng C, Houart C. Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio. Gene Expr Patterns. 2006;6:761-71 pubmed
    ..Here, we describe the cloning of full-length cDNA for sfrp1a, sfrp1b, sfrp2, sfrp3 and sfrp5 gene transcripts and we examine their expression at different embryonic stages...
  4. Liu J, Zhang D, Xie X, Ouyang G, Liu X, Sun Y, et al. Eaf1 and Eaf2 negatively regulate canonical Wnt/?-catenin signaling. Development. 2013;140:1067-78 pubmed publisher
    ..In summary, our evidence points to a novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/?-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity. ..
  5. Collery R, Volberding P, Bostrom J, Link B, Besharse J. Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages. Invest Ophthalmol Vis Sci. 2016;57:6805-6814 pubmed publisher
    ..These mutant zebrafish will be useful in studying the onset and progression of Mfrp-related nanophthalmia, the cues that initiate the recruitment of macrophages, and the mechanisms of Mfrp function. ..
  6. Kamel G, Hoyos T, Rochard L, Dougherty M, Kong Y, Tse W, et al. Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis. Dev Biol. 2013;381:423-33 pubmed publisher
    ..This study examines the functional requirements of frzb and fzd7a in convergence and extension mechanisms during craniofacial development...
  7. Fauny J, Thisse B, Thisse C. The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development. 2009;136:3811-9 pubmed publisher
  8. Rochard L, Monica S, Ling I, Kong Y, Roberson S, Harland R, et al. Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis. Development. 2016;143:2541-7 pubmed publisher
    ..We investigated the role and genetic interactions of Wnt ligands and their trafficking factors Wls, Gpc4 and Frzb in the context of palate morphogenesis in zebrafish...
  9. Seiliez I, Thisse B, Thisse C. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Dev Biol. 2006;290:152-63 pubmed
    ..Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a. ..

More Information

Publications13

  1. Shinya M, Eschbach C, Clark M, Lehrach H, Furutani Seiki M. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev. 2000;98:3-17 pubmed
    ..The nodal gene squint is also required for the maintenance of dkk1 expression. Among the mutually dependent target genes of the pre-MBT Wnt signaling, dkk1 plays an important role in patterning the anterior head of zebrafish. ..
  2. Riera M, Burguera D, Garcia Fern ndez J, Gonz lez Duarte R. CERKL knockdown causes retinal degeneration in zebrafish. PLoS ONE. 2013;8:e64048 pubmed publisher
    ..Overall, we propose that this zebrafish model is a powerful tool to unveil CERKL contribution to human retinal degeneration...
  3. Peng G, Westerfield M. Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development. 2006;133:3191-200 pubmed
    ..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists. ..
  4. Gfrerer L, Shubinets V, Hoyos T, Kong Y, Nguyen C, Pietschmann P, et al. Functional analysis of SPECC1L in craniofacial development and oblique facial cleft pathogenesis. Plast Reconstr Surg. 2014;134:748-59 pubmed publisher