Gene Symbol: foxp3a
Description: forkhead box P3a
Alias: foxp3, forkhead box P3a, forkhead box P3
Mitra S, Alnabulsi A, Secombes C, Bird S. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. FEBS J. 2010;277:128-47 pubmed publisher
..expressed in T cells (t-bet), signal transducer and activator of transcription 6 (stat6) and fork-head box p3 (foxp3), in which two transcripts are present, that are important in the development of a number of these cell types...
Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
Wen Y, Fang W, Xiang L, Pan R, Shao J. Identification of Treg-like cells in Tetraodon: insight into the origin of regulatory T subsets during early vertebrate evolution. Cell Mol Life Sci. 2011;68:2615-26 pubmed publisher
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) are critical for the maintenance of peripheral tolerance, and the suppression of autoimmune diseases and even tumors...
Ojanen M, Turpeinen H, Cordova Z, HammarÃ©n M, Harjula S, Parikka M, et al
. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al
. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al
. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
Kasheta M, Painter C, Moore F, Lobbardi R, Bryll A, Freiman E, et al
. Identification and characterization of T reg-like cells in zebrafish. J Exp Med. 2017;214:3519-3530 pubmed publisher
..Zebrafish mutant for foxp3a displayed excess T lymphocytes, splenomegaly, and a profound inflammatory phenotype that was suppressed by ..
Quintana F, Iglesias A, Farez M, Caccamo M, Burns E, Kassam N, et al
. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS ONE. 2010;5:e9478 pubmed publisher
..In mammals, peripheral tolerance to self-antigens is enforced by Foxp3(+) regulatory T cells...
Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al
. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
..reactivation with apparent symptoms was characterized by a low Th2/Th1 marker ratio and a substantial induction of foxp3 reflecting the level of regulatory T cells...