foxp3a

Summary

Gene Symbol: foxp3a
Description: forkhead box P3a
Alias: foxp3, forkhead box P3a, forkhead box P3
Species: zebrafish

Top Publications

  1. Mitra S, Alnabulsi A, Secombes C, Bird S. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. FEBS J. 2010;277:128-47 pubmed publisher
    ..expressed in T cells (t-bet), signal transducer and activator of transcription 6 (stat6) and fork-head box p3 (foxp3), in which two transcripts are present, that are important in the development of a number of these cell types...
  2. Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
    ..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
  3. Wen Y, Fang W, Xiang L, Pan R, Shao J. Identification of Treg-like cells in Tetraodon: insight into the origin of regulatory T subsets during early vertebrate evolution. Cell Mol Life Sci. 2011;68:2615-26 pubmed publisher
    CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg cells) are critical for the maintenance of peripheral tolerance, and the suppression of autoimmune diseases and even tumors...
  4. Ojanen M, Turpeinen H, Cordova Z, Hammarén M, Harjula S, Parikka M, et al. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
    ..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
  5. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
  6. Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
  7. Kasheta M, Painter C, Moore F, Lobbardi R, Bryll A, Freiman E, et al. Identification and characterization of T reg-like cells in zebrafish. J Exp Med. 2017;214:3519-3530 pubmed publisher
    ..Zebrafish mutant for foxp3a displayed excess T lymphocytes, splenomegaly, and a profound inflammatory phenotype that was suppressed by ..
  8. Quintana F, Iglesias A, Farez M, Caccamo M, Burns E, Kassam N, et al. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS ONE. 2010;5:e9478 pubmed publisher
    ..In mammals, peripheral tolerance to self-antigens is enforced by Foxp3(+) regulatory T cells...
  9. Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
    ..reactivation with apparent symptoms was characterized by a low Th2/Th1 marker ratio and a substantial induction of foxp3 reflecting the level of regulatory T cells...

More Information

Publications11

  1. Zhang B, Shimada Y, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, et al. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98.e3 pubmed publisher
    ..zebrafish genes that are involved in immunity; the expression of plasminogen activator, urokinase, and forkhead box P3 was altered in response to immunologic tolerance...
  2. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher
    ..The development and function of Treg cells are controlled by a master regulatory gene encoding the forkhead box P3 (FOXP3) protein in mammals...