Gene Symbol: foxp2
Description: forkhead box P2
Alias: forkhead box protein P2
Species: zebrafish

Top Publications

  1. Bonkowsky J, Chien C. Molecular cloning and developmental expression of foxP2 in zebrafish. Dev Dyn. 2005;234:740-6 pubmed
    Forkhead domain transcription factors are a large gene family with multiple roles in development. FOXP2, a recently identified member of this family, has been shown to be critical for normal development of language in humans, but little ..
  2. Shah R, Medina Martinez O, Chu L, Samaco R, Jamrich M. Expression of FoxP2 during zebrafish development and in the adult brain. Int J Dev Biol. 2006;50:435-8 pubmed
    ..Mutations in the human FOXP2 gene cause abnormal speech development. Here we report the structure and expression pattern of zebrafish FoxP2...
  3. Cheng L, Chong M, Fan W, Guo X, Zhang W, Yang X, et al. Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish. Dev Genes Evol. 2007;217:699-707 pubmed
    ..These results provide evidence that foxp1 is likely to function as a very important transcription factor in the development of the central nervous system and many other organs in zebrafish. ..
  4. Bonkowsky J, Wang X, Fujimoto E, Lee J, Chien C, Dorsky R. Domain-specific regulation of foxP2 CNS expression by lef1. BMC Dev Biol. 2008;8:103 pubmed publisher
    b>FOXP2 is a forkhead transcription factor critical for normal development of language in humans, but little is known of its broader function and regulation during central nervous system (CNS) development...
  5. Stevenson T, Trinh T, Kogelschatz C, Fujimoto E, Lush M, Piotrowski T, et al. Hypoxia disruption of vertebrate CNS pathfinding through ephrinB2 Is rescued by magnesium. PLoS Genet. 2012;8:e1002638 pubmed publisher
    ..These results demonstrate that evolutionarily conserved genetic pathways regulate connectivity changes in the CNS in response to hypoxia, and they support a potential neuroprotective role for magnesium. ..
  6. Coutinho P, Pavlou S, Bhatia S, Chalmers K, Kleinjan D, van Heyningen V. Discovery and assessment of conserved Pax6 target genes and enhancers. Genome Res. 2011;21:1349-59 pubmed publisher
    ..We have identified several novel direct targets, including some putative disease genes, among them Foxp2; these will allow further dissection of Pax6 function in development and disease.
  7. Xing L, Hoshijima K, Grunwald D, Fujimoto E, Quist T, Sneddon J, et al. Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding. PLoS ONE. 2012;7:e43968 pubmed publisher
    b>foxP2, a forkhead-domain transcription factor, is critical for speech and language development in humans, but its role in the establishment of CNS connectivity is unclear...
  8. Pappalardo Carter D, Balaraman S, Sathyan P, Carter E, Chen W, Miranda R. Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models. Alcohol Clin Exp Res. 2013;37:1657-67 pubmed publisher
    ..We also assessed the expression of developmentally important, and known miR-9 targets, FGFR-1, FOXP2, and the nontargeted transcript, MECP2...
  9. Nikolaou N, Meyer M. Lamination Speeds the Functional Development of Visual Circuits. Neuron. 2015;88:999-1013 pubmed publisher
    ..Thus, the formation of synaptic laminae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembly of these networks. ..

More Information


  1. Algama M, Tasker E, Williams C, Parslow A, Bryson Richardson R, Keith J. Genome-wide identification of conserved intronic non-coding sequences using a Bayesian segmentation approach. BMC Genomics. 2017;18:259 pubmed publisher
    ..We attribute the higher sensitivity of the pathway-focussed analysis compared to the genome-wide analysis to improved alignment quality, suggesting that enhanced genomic alignments may reveal many more conserved intronic sequences. ..