Gene Symbol: foxo3a
Description: forkhead box O3A
Alias: wu:fb50g02, wu:fi33f07, zgc:92176, forkhead box O3A, fb50g02, fi33f07
Species: zebrafish

Top Publications

  1. Peng K, Li Y, Long L, Li D, Jia Q, Wang Y, et al. Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neurosci Lett. 2010;484:98-103 pubmed publisher
    ..FoxO transcription factors regulate apoptosis in vitro in deprived of neurotrophins. It is unknown if FoxO3a is involved in the development of neurons...
  2. Sagi D, Kim S. An engineering approach to extending lifespan in C. elegans. PLoS Genet. 2012;8:e1002780 pubmed publisher
    ..Using engineering to add novel functions and to tune endogenous functions provides a new framework for lifespan extension that goes beyond the constraints of the worm genome. ..
  3. Liu X, Cai X, Hu B, Mei Z, Zhang D, Ouyang G, et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291:25692-25705 pubmed
    b>FOXO3a, a member of the forkhead homeobox type O (FOXO) family of transcriptional factors, regulates cell survival in response to DNA damage, caloric restriction, and oxidative stress...
  4. Lin S, Chiang M, Shih H, Chiang K, Cheng Y. Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Dev Genes Evol. 2017;227:219-230 pubmed publisher
    ..Our results suggest that foxo4, foxo6a, and foxo6b play important roles in the developing brain and retina and that the transcriptional levels of these genes are regulated by PI3-kinase signaling. ..
  5. Shimizu H, Langenbacher A, Huang J, Wang K, Otto G, Geisler R, et al. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. elife. 2017;6: pubmed publisher
    ..Together, our findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway. ..
  6. Xie X, Liu J, Hu B, Xiao W. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS ONE. 2011;6:e24469 pubmed publisher
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis. ..
  7. Rakshambikai R, Srinivasan N, Gadkari R. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. J Bioinform Comput Biol. 2014;12:1350014 pubmed publisher
    ..Hence, in depth analysis of PIM kinases in zebrafish has opened up new avenues of research to verify the model organism status of zebrafish. ..
  8. Meng X, Chen B, Zhang J. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci. 2017;13:985-995 pubmed publisher