Gene Symbol: foxl2a
Description: forkhead box L2a
Alias: foxl2, foxl2-1, foxl2-2, zgc:136549, forkhead box protein L2, forkhead box L2, forkhead box L2-1, forkhead box L2-2
Species: zebrafish

Top Publications

  1. Caulier M, Brion F, Chadili E, Turies C, Piccini B, Porcher J, et al. Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio). Comp Biochem Physiol A Mol Integr Physiol. 2015;188:96-106 pubmed publisher estrogen and androgen production (Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b) and one of their regulators (Foxl2a) in zebrafish gonads...
  2. Hua J, Han J, Guo Y, Zhou B. The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquat Toxicol. 2015;166:1-9 pubmed publisher
    ..g., cyp19a1a, cyp19a1b), the forkhead transcription factor gene L2 (foxl2) and the Fushi tarazu factor-1d (nr5a1b) were observed...
  3. Webster K, Schach U, Ordaz A, Steinfeld J, Draper B, Siegfried K. Dmrt1 is necessary for male sexual development in zebrafish. Dev Biol. 2017;422:33-46 pubmed publisher
    ..that Dmrt1 is necessary for normal transcriptional regulation of the amh (anti-Müllerian hormone) and foxl2 (forkhead box L2) genes, which are thought to be important for male or female sexual development respectively...
  4. Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
  5. Zhang X, Gao L, Yang K, Tian H, Wang W, Ru S. Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2013;157:33-40 pubmed publisher
    ..001 and 0.100 mg/L MCP. MCP exposure stimulated forkhead transcription factor gene L2 (foxl2) expression and suppressed doublesex/mab-3 related transcription factor 1 (dmrt1) expression, indirectly leading ..
  6. Yin Y, Tang H, Liu Y, Chen Y, Li G, Liu X, et al. Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish. Endocrinology. 2017;158:3030-3041 pubmed publisher
    ..Collectively, our results revealed dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation. ..
  7. Jiang W, Yang Y, Zhao D, Liu X, Duan J, Xie S, et al. Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus. Comp Biochem Physiol B Biochem Mol Biol. 2011;160:187-93 pubmed publisher
    ..Exogenous sex steroids can affect sex differentiation and the expression of sex-related genes. Foxl2, a member of forkhead-box transcription factor family, is the key gene for ovary development and its mutation ..
  8. Zhang Z, Lau S, Zhang L, Ge W. Disruption of Zebrafish Follicle-Stimulating Hormone Receptor (fshr) But Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males. Endocrinology. 2015;156:3747-62 pubmed publisher
    ..Neither Fshr nor Lhcgr deficiency could phenocopy the deficiency of their cognate ligands FSH and LH, which is likely due to the fact that Fshr can be activated by both FSH and LH in the zebrafish. ..
  9. Chen S, Zhang H, Wang F, Zhang W, Peng G. nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation. Mol Cell Endocrinol. 2016;433:105-16 pubmed publisher
    ..Together, our results suggest nr0b1 regulates somatic cell differentiation and cell proliferation to ensure normal sex development in the zebrafish. ..

More Information


  1. Di Rosa V, López Olmeda J, Burguillo A, Frigato E, Bertolucci C, Piferrer F, et al. Daily Rhythms of the Expression of Key Genes Involved in Steroidogenesis and Gonadal Function in Zebrafish. PLoS ONE. 2016;11:e0157716 pubmed publisher
    ..The expression of foxl2 (forkhead box L2) was also rhythmic in the ovary (acrophase located at ZT 5:02 h) and the expression of dmrt1 (doublesex and ..
  2. Chen W, Liu L, Ge W. Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio. Biol Reprod. 2017;96:401-413 pubmed publisher
    ..Our data suggested that Gdf9 is likely involved in promoting oocyte/ovary differentiation in the zebrafish and it may act by suppressing amh expression, at least partly, in the somatic cells. ..