Gene Symbol: foxl1
Description: forkhead box L1
Alias: zgc:63595, forkhead box protein L1
Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics. 2010;11:548 pubmed publisher
Zheng D, Kille P, Feeney G, Cunningham P, Handy R, Hogstrand C. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 2010;11:553 pubmed publisher
..This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components...
Nakada C, Satoh S, Tabata Y, Arai K, Watanabe S. Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish. Mol Cell Biol. 2006;26:7246-57 pubmed
..ectopic expression of shh in the midbrain and elevated pax2a expression in the optic stalk were observed in foxl1 MO-injected embryos...
Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
Cui S, Leyva Vega M, Tsai E, Eauclaire S, Glessner J, Hakonarson H, et al
. Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology. 2013;144:1107-1115.e3 pubmed publisher
..Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA. ..
Tang V, COFER Z, Cui S, Sapp V, Loomes K, Matthews R. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr. 2016;63:524-530 pubmed
..Our results support previous studies identifying ADD3 as a putative genetic risk factor for BA susceptibility. Our results also provide evidence that add3a may be affecting the Hh pathway, an important factor in BA pathogenesis. ..