Gene Symbol: foxj1a
Description: forkhead box J1a
Alias: foxj1, id:ibd5134, zgc:153050, forkhead box protein J1-A, forkhead box transcription factor J1
Species: zebrafish

Top Publications

  1. Aamar E, Dawid I. Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos. Int J Dev Biol. 2008;52:985-91 pubmed publisher
    ..present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish...
  2. Neugebauer J, Amack J, Peterson A, Bisgrove B, Yost H. FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature. 2009;458:651-4 pubmed publisher
    ..Abrogation of Fgfr1 signalling downregulates expression of two ciliogenic transcription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polaris), indicating that FGF signalling ..
  3. Tay S, Yu X, Wong K, Panse P, Ng C, Roy S. The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Dev Dyn. 2010;239:527-34 pubmed publisher
    ..Iguana localizes to the base of primary and motile cilia, in the immediate vicinity or closely associated with the basal bodies. These findings identify the Iguana protein as a novel and critical component of ciliogenesis. ..
  4. Lopes S, Lourenço R, Pacheco L, Moreno N, Kreiling J, Saude L. Notch signalling regulates left-right asymmetry through ciliary length control. Development. 2010;137:3625-32 pubmed publisher
    ..deltaD zebrafish mutants, cilia length is reduced in Kupffer's vesicle and can be rescued by the ciliogenic factor foxj1a. Conversely, cilia length increases when Notch signalling is hyperactivated...
  5. Zhang M, Zhang J, Lin S, Meng A. ?-Catenin 1 and ?-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development. 2012;139:2009-19 pubmed publisher
    ..Taken together, our findings suggest that ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms. ..
  6. Hellman N, Liu Y, Merkel E, Austin C, Le Corre S, Beier D, et al. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A. 2010;107:18499-504 pubmed publisher
    ..Zebrafish foxj1a, but not foxj1b, was rapidly induced in response to epithelial distension and stretch, kidney cyst formation, ..
  7. Stubbs J, Oishi I, Izpisua Belmonte J, Kintner C. The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat Genet. 2008;40:1454-60 pubmed publisher
    ..We address this issue by analyzing the Xenopus and zebrafish homologs of Foxj1, a forkhead transcription factor necessary for ciliogenesis in multiciliated cells of the mouse...
  8. Yu X, Ng C, Habacher H, Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat Genet. 2008;40:1445-53 pubmed publisher
    ..Here we show that a zebrafish Foxj1 homolog, foxj1a, is a target of Hedgehog signaling in the floor plate...
  9. Tian T, Zhao L, Zhang M, Zhao X, Meng A. Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochem Biophys Res Commun. 2009;380:537-42 pubmed publisher
    ..The zebrafish genome expressed two paralogous foxj1 genes, foxj1a and foxj1b...

More Information


  1. Caron A, Xu X, Lin X. Wnt/?-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012;139:514-24 pubmed publisher
    ..Here, we report that Wnt/?-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle (KV)...
  2. Tavares B, Jacinto R, Sampaio P, Pestana S, Pinto A, Vaz A, et al. Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer. elife. 2017;6: pubmed publisher
    b>Foxj1a is necessary and sufficient to specify motile cilia...
  3. Jurisch Yaksi N, Rose A, Lu H, Raemaekers T, Munck S, Baatsen P, et al. Rer1p maintains ciliary length and signaling by regulating ?-secretase activity and Foxj1a levels. J Cell Biol. 2013;200:709-20 pubmed publisher
    ..We further demonstrate that Rer1p depletion reduced ciliary length and function by increasing ?-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression.
  4. Li N, Wei C, Olena A, Patton J. Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development. Development. 2011;138:1817-26 pubmed publisher
  5. Zhao L, Yuan S, Cao Y, Kallakuri S, Li Y, Kishimoto N, et al. Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proc Natl Acad Sci U S A. 2013;110:12697-702 pubmed publisher
  6. Liu D, Hsu C, Tsai S, Hsiao C, Wang W. A variant of fibroblast growth factor receptor 2 (Fgfr2) regulates left-right asymmetry in zebrafish. PLoS ONE. 2011;6:e21793 pubmed publisher
    ..Furthermore, KV cilia were shorter in fgfr2c morphants. We conclude that the fgfr2c isoform plays an important role in the left-right asymmetry during zebrafish development. ..
  7. Serifi I, Tzima E, Soupsana K, Karetsou Z, Beis D, Papamarcaki T. The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development. Biochem J. 2016;473:4609-4627 pubmed
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development. ..
  8. Zhou F, Narasimhan V, Shboul M, Chong Y, Reversade B, Roy S. Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Curr Biol. 2015;25:3267-73 pubmed
    ..protein Multicilin, which transcriptionally activates genes for basal body production and the gene for FoxJ1, the master regulator for basal body docking, cilia formation, and motility [7, 8]...
  9. He L, Xu W, Jing Y, Wu M, Song S, Cao Y, et al. Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int J Biol Sci. 2015;11:935-47 pubmed publisher
    ..Taken together, our data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development. ..
  10. Zou J, Li W, Li Q, Li X, Zhang J, Liu G, et al. Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish. Circ Res. 2011;108:201-9 pubmed publisher
    ..Two functional endothelial cell-specific miRNAs, miR-126a and miR-126b, synergistically regulate zebrafish vascular integrity, and pak1 is a critical target of miR-126a/b in vascular development. ..
  11. Verleyen D, Luyten F, Tylzanowski P. Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle. PLoS ONE. 2014;9:e110484 pubmed publisher
    ..Further, we found that Gpr22 does not act upstream of the two cilia master regulators, Foxj1a and Rfx2. To conclude, our study characterized a novel player in the field of ciliogenesis.
  12. Ribeiro A, Monteiro J, Certal A, Cristovão A, Saude L. Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish. Open Biol. 2017;7: pubmed publisher
    ..Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a ..
  13. Xu W, Jin M, Hu R, Wang H, Zhang F, Yuan S, et al. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. J Am Soc Nephrol. 2017;28:118-129 pubmed publisher
  14. Hu H, Xin N, Liu J, Liu M, Wang Z, Wang W, et al. Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts. Gene. 2016;575:623-31 pubmed publisher
    ..Furthermore, the expression of genes related to nervous system development (spon1b, foxo3b, and foxj1a) was significantly increased after the injection of PoF-spondin into the embryos of wild-type zebrafish...
  15. Neugebauer J, Cadwallader A, Amack J, Bisgrove B, Yost H. Differential roles for 3-OSTs in the regulation of cilia length and motility. Development. 2013;140:3892-902 pubmed publisher
    ..functions in the fibroblast growth factor pathway to control cilia length via the ciliogenic transcription factors FoxJ1a and Rfx2...
  16. Li M, Hu X, Zhu J, Zhu C, Zhu S, Liu X, et al. Overexpression of miR-19b impairs cardiac development in zebrafish by targeting ctnnb1. Cell Physiol Biochem. 2014;33:1988-2002 pubmed publisher
    ..Our findings suggest that miR-19b regulates laterality development and heart looping in zebrafish embryos by targeting ctnnb1. ..
  17. Dutta S, Sriskanda S, Boobalan E, Alur R, Elkahloun A, Brooks B. nlz1 is required for cilia formation in zebrafish embryogenesis. Dev Biol. 2015;406:203-11 pubmed publisher
    ..In vitro and in vivo data indicate that Nlz1 acts downstream of Foxj1a and Wnt8a/presumed canonical Wnt signaling...
  18. Zhu P, Xu X, Lin X. Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biol Open. 2015;4:1376-86 pubmed publisher our recent discovery that Wnt signaling regulates ciliogenesis in the zebrafish Kupffer's vesicle (KV) via Foxj1a, a ciliogenic transcription factor, we decided to elucidate functions of Foxj1a in Wnt-regulated LR pattern ..
  19. Wang L, Liu Z, Lin H, Ma D, Tao Q, Liu F. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017;36:2987-2997 pubmed publisher
    ..1 regulates collective DFC migration through cadherin 1 (Cdh1). Taken together, our data uncover dynamic DNA methylation as an epigenetic mechanism to control LR determination during early embryogenesis in vertebrates. ..
  20. Jin D, Ni T, Sun J, Wan H, Amack J, Yu G, et al. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol. 2014;16:841-51 pubmed publisher
    ..These findings lead us to propose that Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde IFT, thereby promoting ciliogenesis. ..
  21. Lu H, Toh M, Narasimhan V, Thamilselvam S, Choksi S, Roy S. A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Dev Biol. 2015;397:225-36 pubmed publisher
    ..arl13b is induced by FoxJ1 and Rfx, and these ciliogenic transcription factors are unable to promote ciliary length increase when Arl13b ..
  22. Grimes D, Boswell C, Morante N, Henkelman R, Burdine R, Ciruna B. Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science. 2016;352:1341-4 pubmed publisher
  23. Vij S, Rink J, Ho H, Babu D, Eitel M, Narasimhan V, et al. Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. PLoS Genet. 2012;8:e1003019 pubmed publisher
    ..In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis...
  24. Kim H, Richardson J, van Eeden F, Ingham P. Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish. BMC Biol. 2010;8:65 pubmed publisher
  25. Reiten I, Uslu F, Foré S, Pelgrims R, Ringers C, Diaz Verdugo C, et al. Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations. Curr Biol. 2017;27:166-174 pubmed publisher
    ..Altogether, our work unravels a central function of ciliary beating for generating flow fields that increase the sensitivity and the temporal resolution of olfactory computations in the vertebrate brain. ..
  26. Aamar E, Dawid I. Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. Dev Dyn. 2010;239:2980-8 pubmed publisher
    ..These defects correlated with the formation of small KVs with apparently diminished cilia, consistent with the known requirement for ciliary function in the laterality organ for the establishment of L-R asymmetry. ..
  27. Znosko W, Yu S, Thomas K, Molina G, Li C, Tsang W, et al. Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Dev Biol. 2010;342:11-25 pubmed publisher
    ..We further demonstrated the interaction of Pea3 ETS factors with the Dusp6 promoter both in vitro and in vivo. These results revealed the requirement of ETS factors in transducing FGF signals in developmental processes. ..
  28. Sedykh I, Teslaa J, Tatarsky R, Keller A, Toops K, Lakkaraju A, et al. Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia. Sci Rep. 2016;6:34437 pubmed publisher
    ..These data identify novel roles for Rsph9 in 9?+?0 motile cilia and in sensory kinocilia, and establish a useful zebrafish PCD model. ..
  29. Frisca F, Colquhoun D, Goldshmit Y, Ankö M, Pebay A, Kaslin J. Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish. Sci Rep. 2016;6:37678 pubmed publisher
    ..Overall, this study demonstrates an essential role of enpp2/LPA signalling during early embryogenesis. ..
  30. Tian T, Zhao L, Zhao X, Zhang M, Meng A. A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b. J Genet Genomics. 2009;36:581-9 pubmed publisher
    ..The zebrafish or Xenopus genome expresses two Foxj1 genes, foxj1a/FoxJ1 and foxj1b/FoxJ1.2...