foxi1

Summary

Gene Symbol: foxi1
Description: forkhead box i1
Alias: cb724, foo, forkhead box protein I2, hearsay, hsy, no soul, nos, quadro, quo(l)
Species: zebrafish

Top Publications

  1. Sun S, Dee C, Tripathi V, Rengifo A, Hirst C, Scotting P. Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent. Dev Biol. 2007;303:675-86 pubmed
    ..However, the forkhead factor, Foxi1, is required for both otic and epibranchial placode development...
  2. Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol. 2006;294:376-90 pubmed
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border. ..
  3. Yan J, Xu L, Crawford G, Wang Z, Burgess S. The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. Mol Cell Biol. 2006;26:155-68 pubmed
    ..We created a stable cell line expressing FoxI1-green fluorescent protein (GFP) or FoxI1-V5 fusion proteins under control of the reverse tetracycline-controlled ..
  4. Kwon H, Riley B. Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue. Dev Dyn. 2009;238:1582-94 pubmed publisher
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc. ..
  5. Nechiporuk A, Linbo T, Raible D. Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Development. 2005;132:3717-30 pubmed
    ..Surprisingly, ectodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endoderm-deficient embryos and ..
  6. Rhinn M, Lun K, Luz M, Werner M, Brand M. Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development. 2005;132:1261-72 pubmed
    ..Our findings argue that graded Wnt8 activity mediates overall neuroectodermal posteriorization and thus determines the location of the MHB organizer. ..
  7. Padanad M, Riley B. Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. Dev Biol. 2011;351:90-8 pubmed publisher
    ..In zebrafish, both are initiated by localized Fgf signaling plus the ubiquitous competence factor Foxi1, and both express pax8 and sox3 in response...
  8. Nechiporuk A, Linbo T, Poss K, Raible D. Specification of epibranchial placodes in zebrafish. Development. 2007;134:611-23 pubmed
    ..Here, we show that zebrafish embryos mutant for fgf3 and fgf8 do not express early EB placode markers, including foxi1 and pax2a...
  9. Hans S, Christison J, Liu D, Westerfield M. Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev Biol. 2007;7:5 pubmed
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all ..

More Information

Publications60

  1. Hans S, Liu D, Westerfield M. Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development. 2004;131:5091-102 pubmed
    ..further provide evidence that pax8 expression and pax2a expression are regulated by two independent factors, Foxi1 and Dlx3b, respectively. Combined loss of both factors eliminates all indications of otic specification...
  2. Solomon K, Kwak S, Fritz A. Genetic interactions underlying otic placode induction and formation. Dev Dyn. 2004;230:419-33 pubmed
    ..In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest-acting genes in this process...
  3. Nissen R, Yan J, Amsterdam A, Hopkins N, Burgess S. Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Development. 2003;130:2543-54 pubmed
    ..We identified foxi one (foo), the zebrafish ortholog of Foxi1 (FREAC6, FKHL10, HFH-3, Fkh10) and a member of the forkhead domain transcriptional regulator family, as the gene ..
  4. Solomon K, Kudoh T, Dawid I, Fritz A. Zebrafish foxi1 mediates otic placode formation and jaw development. Development. 2003;130:929-40 pubmed
    ..Here, we identify a mutation in zebrafish, hearsay, which disrupts the initiation of placode formation...
  5. Hans S, Irmscher A, Brand M. Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development. 2013;140:1936-45 pubmed publisher
    ..In zebrafish, the otic-epibranchial progenitor domain (OEPD) is induced by Fgf signaling in a Foxi1- and Dlx3b/4b-dependent manner, but the functional differences of Foxi1 and Dlx3b/4b in subsequent cell fate ..
  6. Kudoh T, Concha M, Houart C, Dawid I, Wilson S. Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development. 2004;131:3581-92 pubmed
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue. ..
  7. Esaki M, Hoshijima K, Nakamura N, Munakata K, Tanaka M, Ookata K, et al. Mechanism of development of ionocytes rich in vacuolar-type H(+)-ATPase in the skin of zebrafish larvae. Dev Biol. 2009;329:116-29 pubmed publisher
    ..In the present study, we analyzed a zebrafish mutant, quadro (quo), deficient in foxi1 gene expression and found that foxi1 is essential for development of an MRC ..
  8. Lee S, Shen E, Fiser A, Sali A, Guo S. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development. 2003;130:2669-79 pubmed
    ..Here we report that the zebrafish mutation no soul, in which epibranchial placodes are defective, disrupts the fork headrelated, winged helix domain-containing ..
  9. Seiliez I, Thisse B, Thisse C. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Dev Biol. 2006;290:152-63 pubmed
    ..Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a. ..
  10. LeClair E, Mui S, Huang A, Topczewska J, Topczewski J. Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants. Dev Dyn. 2009;238:2550-63 pubmed publisher
    ..In contrast, gpc4(-/-) larvae never form these domains, suggesting a failure of chondrocyte orientation, though not differentiation. Our findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis. ..
  11. Xie X, Liu J, Hu B, Xiao W. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS ONE. 2011;6:e24469 pubmed publisher
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis. ..
  12. Dutton K, Abbas L, Spencer J, Brannon C, Mowbray C, Nikaido M, et al. A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Dis Model Mech. 2009;2:68-83 pubmed publisher
    ..We discuss the implication that the deafness in WS4 patients with SOX10 mutations might reflect a haploinsufficiency for SOX10 in the otic epithelium, resulting in patterning and functional abnormalities in the inner ear. ..
  13. Guo S, Wilson S, Cooke S, Chitnis A, Driever W, Rosenthal A. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999;208:473-87 pubmed
    ..The too few mutation leads to a specific reduction in the number of hypothalamic DA neurons. no soul lacks arch-associated NA cells and has defects in pharyngeal arches, and soulless lacks both arch-associated and ..
  14. Dee C, Gibson A, Rengifo A, Sun S, Patient R, Scotting P. A change in response to Bmp signalling precedes ectodermal fate choice. Int J Dev Biol. 2007;51:79-84 pubmed
    ..Hence, we have shown a dynamic change in the molecular machinery underlying the Bmp response in the ectoderm during gastrulation stages of development. ..
  15. Malicki J, Schier A, Solnica Krezel L, Stemple D, Neuhauss S, Stainier D, et al. Mutations affecting development of the zebrafish ear. Development. 1996;123:275-83 pubmed
    ..Embryos mutant at the quadro locus display abnormal specification of the otic placode...
  16. Edlund R, Ohyama T, Kantarci H, Riley B, Groves A. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014;390:1-13 pubmed publisher
    ..Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 also causes ..
  17. Solomon K, Logsdon J, Fritz A. Expression and phylogenetic analyses of three zebrafish FoxI class genes. Dev Dyn. 2003;228:301-7 pubmed publisher
    ..We have reported previously the identification of zebrafish foxi1, which is required for otic placode and jaw development...
  18. Hu Z, Zhang Q, Qin W, Tong J, Zhao Q, Han Y, et al. Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish. Cell Death Dis. 2013;4:e900 pubmed publisher
    ..Mil) dysregulation also caused abnormal expression of hearing-associated genes, including hmx2, fgf3, fgf8a, foxi1, otop1, pax2.1 and tmieb during zebrafish organogenesis...
  19. Dutta S, Dawid I. Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development. 2010;137:3013-8 pubmed publisher
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  20. Nicolson T. The genetics of hearing and balance in zebrafish. Annu Rev Genet. 2005;39:9-22 pubmed
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish. ..
  21. Zeng J, Yan J, Wang T, Mosbrook Davis D, Dolan K, Christensen R, et al. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic Acids Res. 2008;36:e8 pubmed
    ..The experimental approach was validated with the tumor suppressor protein p53 and the forkhead protein FoxI1 using genomic libraries for zebrafish and mouse generated by shotgun cloning of short genomic fragments...
  22. Wendl T, Adzic D, Schoenebeck J, Scholpp S, Brand M, Yelon D, et al. Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development. 2007;134:2871-9 pubmed
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects. ..
  23. Poulain M, Fürthauer M, Thisse B, Thisse C, Lepage T. Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development. 2006;133:2189-200 pubmed
    ..These results identify a molecular mechanism whereby FGF attenuates Nodal-induced endodermal transcription factors and highlight a potential mechanism whereby mesoderm and endoderm fates could segregate from each other. ..
  24. Long L, Guo H, Yao D, Xiong K, Li Y, Liu P, et al. Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio. Cell Res. 2015;25:638-41 pubmed publisher
  25. Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
  26. Harvey S, Sealy I, Kettleborough R, Fényes F, White R, STEMPLE D, et al. Identification of the zebrafish maternal and paternal transcriptomes. Development. 2013;140:2703-10 pubmed publisher
  27. Barresi M, Burton S, Dipietrantonio K, Amsterdam A, Hopkins N, Karlstrom R. Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn. 2010;239:2603-18 pubmed publisher
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS. ..
  28. Yao D, Zhao F, Wu Y, Wang J, Dong W, Zhao J, et al. Dissecting the differentiation process of the preplacodal ectoderm in zebrafish. Dev Dyn. 2014;243:1338-51 pubmed publisher
    ..The caudal PPR fate dominates when foxi1 expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) ..
  29. Lu F, Sun Y, Wei C, Thisse C, Thisse B. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun. 2014;5:5368 pubmed publisher
    ..These findings reveal a novel level of regulation of the canonical Wnt/β-catenin signalling pathway occurring in the nucleus and involving tissue-specific derepression of TCF by Lbx2. ..
  30. Hammond K, van Eeden F, Whitfield T. Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development. 2010;137:1361-71 pubmed publisher
  31. Cruz C, Maegawa S, Weinberg E, Wilson S, Dawid I, Kudoh T. Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos. Proc Natl Acad Sci U S A. 2010;107:3564-9 pubmed publisher
    ..We conclude that eve1 is crucial for the organization of the antero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting activity...
  32. Belting H, Wendik B, Lunde K, Leichsenring M, Mössner R, Driever W, et al. Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression. Dev Biol. 2011;356:323-36 pubmed publisher
    ..Our data reveals a set of direct and indirect interactions of Pou5f1 with the BMP dorsoventral patterning network that serve to fine-tune dorsoventral patterning mechanisms and coordinate patterning with developmental timing. ..
  33. Padanad M, Bhat N, Guo B, Riley B. Conditions that influence the response to Fgf during otic placode induction. Dev Biol. 2012;364:1-10 pubmed publisher
    ..Elevated Fgf also expands expression of the putative competence factor Foxi1, which is required for Fgf to expand other otic markers...
  34. Serifi I, Tzima E, Soupsana K, Karetsou Z, Beis D, Papamarcaki T. The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development. Biochem J. 2016;473:4609-4627 pubmed
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development. ..
  35. Wang X, He H, Tang W, Zhang X, Hua X, Yan J. Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw. PLoS ONE. 2012;7:e45380 pubmed publisher
    ..These cells are transformed into two populations of blastemal progenitors: foxi1-expression and isl1-expression, before giving rise to cartilage, bone, and muscle...
  36. Liu J, Xu Q, Li S, Yu X, Liu W, Ouyang G, et al. Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-? signaling. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1103-1116 pubmed publisher
  37. Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, et al. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev. 2014;23:1899-909 pubmed publisher
    ..Our results extended the cellular role of Zdhhc13, suggesting that it acts as a regulator in BMP signaling, and established that the embryonic function of Zdhhc13 is in lineage specification. ..
  38. Mackereth M, Kwak S, Fritz A, Riley B. Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode. Development. 2005;132:371-82 pubmed
    ..In contrast, the phenotype caused by disrupting foxi1, which is required for pax8 expression, was not enhanced by simultaneously disrupting pax8...
  39. Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, et al. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development. 2005;132:3731-42 pubmed
    ..Our results show that the endoderm regulates the differentiation of cranial sensory ganglia, which coordinates the cranial nerves with the segments that they innervate...
  40. Jia S, Dai F, Wu D, Lin X, Xing C, Xue Y, et al. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Dev Cell. 2012;22:1065-78 pubmed publisher
    ..We conclude that Ppp4c is a critical positive regulator of BMP/Smad signaling during embryonic dorsoventral pattern formation in zebrafish. ..
  41. Kwon H, Bhat N, Sweet E, Cornell R, Riley B. Identification of early requirements for preplacodal ectoderm and sensory organ development. PLoS Genet. 2010;6:e1001133 pubmed publisher
    ..Initially, Bmp is required before gastrulation to co-induce four transcription factors, Tfap2a, Tfap2c, Foxi1, and Gata3, which establish preplacodal competence throughout the nonneural ectoderm...
  42. McCarroll M, Nechiporuk A. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PLoS ONE. 2013;8:e85087 pubmed publisher
    ..These findings highlight the importance and complexity of reiterated Fgf signaling during cranial placode formation and subsequent sensory organ development. ..
  43. Kucenas S, Cox J, Soto F, Lamora A, Voigt M. Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish. Purinergic Signal. 2009;5:395-407 pubmed publisher
    ..These data suggest that p2rx3.1 function in ectodermal cells is involved in purinergic signaling essential for proper craniofacial development and sensory circuit formation in the embryonic and larval zebrafish. ..
  44. Dal Pra S, Fürthauer M, Van Celst J, Thisse B, Thisse C. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Dev Biol. 2006;298:514-26 pubmed
  45. Bhat N, Kwon H, Riley B. A gene network that coordinates preplacodal competence and neural crest specification in zebrafish. Dev Biol. 2013;373:107-17 pubmed publisher
    ..Elevated Bmp establishes preplacodal competence throughout the ventral ectoderm by coinducing Tfap2a, Tfap2c, Foxi1 and Gata3...
  46. Hwang P, Chou M. Zebrafish as an animal model to study ion homeostasis. Pflugers Arch. 2013;465:1233-47 pubmed publisher
  47. Hogan B, Hunter M, Oates A, Crowhurst M, Hall N, Heath J, et al. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol. 2004;276:508-22 pubmed
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies. ..
  48. Wei C, Wang H, Zhu Z, Sun Y. Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. J Biol Chem. 2014;289:6604-18 pubmed publisher
    ..In conclusion, our study uncovers that smad1 and smad9 act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis. ..
  49. Abbas L, Whitfield T. Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development. 2009;136:2837-48 pubmed publisher
    ..This exemplifies the use of morpholinos as potential therapeutic agents for genetic disease...
  50. Varga M, Maegawa S, Bellipanni G, Weinberg E. Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mech Dev. 2007;124:775-91 pubmed
  51. Hans S, Westerfield M. Changes in retinoic acid signaling alter otic patterning. Development. 2007;134:2449-58 pubmed
    ..Excess RA leads to ectopic foxi1 expression throughout the entire preplacodal domain. Foxi1 provides competence to adopt an otic fate...