foxi1

Summary

Gene Symbol: foxi1
Description: forkhead box i1
Alias: cb724, foo, hearsay, hsy, no soul, nos, quadro, quo(l)
Species: zebrafish

Top Publications

  1. pmc Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:3581-92. 2004
  2. ncbi FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation
    Iban Seiliez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France
    Dev Biol 290:152-63. 2006
  3. ncbi Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
    Shun Kuo Sun
    Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 303:675-86. 2007
  4. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
  5. pmc Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 238:1582-94. 2009
  6. ncbi Zebrafish foxi1 mediates otic placode formation and jaw development
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 130:929-40. 2003
  7. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
  8. ncbi Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 294:376-90. 2006
  9. pmc The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure
    Jizhou Yan
    National Human Genome Research Institute, Genome Technology Branch, NIH, Bldg 50, Rm 5537, 50 South Dr, Bethesda, MD 20892, USA
    Mol Cell Biol 26:155-68. 2006
  10. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004

Research Grants

  1. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
  2. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009

Scientific Experts

  • Pung Pung Hwang
  • Stefan Hans
  • TERESA A NICOLSON
  • Tetsuhiro Kudoh
  • Sergey Yaklichkin
  • MICHAEL J BARRESI
  • Bruce B Riley
  • Hye Joo Kwon
  • Neha Bhat
  • Mahesh S Padanad
  • Jizhou Yan
  • Keely S Solomon
  • Andreas Fritz
  • Alexei Nechiporuk
  • Tanya T Whitfield
  • Leila Abbas
  • Eric S Weinberg
  • Igor B Dawid
  • Shun Kuo Sun
  • Chris T Dee
  • Christine Thisse
  • Bernard Thisse
  • Shawn M Burgess
  • Steven A Harvey
  • Xuelong Wang
  • Shunji Jia
  • Heinz Georg Belting
  • Xun Wei Xie
  • Sunit Dutta
  • Katherine L Hammond
  • Carlos Cruz
  • Sarah Kucenas
  • Masahiro Esaki
  • Kirsten Dutton
  • Elizabeth E LeClair
  • Shingo Maegawa
  • Jue Zeng
  • Máté Varga
  • Thomas Wendl
  • Andrea Rengifo
  • Paul J Scotting
  • Michael Brand
  • Tor Linbo
  • Bryan T Phillips
  • David W Raible
  • Iban Seiliez
  • Morgane Poulain
  • Maximilian Fürthauer
  • Sophie Dal-Pra
  • Jochen Holzschuh
  • Melinda D Mackereth
  • Muriel Rhinn
  • Su Jin Kwak
  • Benjamin M Hogan
  • Robert M Nissen
  • DEREK STEMPLE
  • James C Smith
  • Ian Sealy
  • Richard White
  • Ross Kettleborough
  • Fruzsina Fényes
  • Cencan Xing
  • Huihui He
  • Ying Wang
  • Xianxin Hua
  • Xin Hua Feng
  • Xia Lin
  • Mu Xiao
  • Anming Meng
  • Wei Wu
  • Biwei Guo
  • Fangyan Dai
  • Xin A Zhang
  • Di Wu
  • Wenqiao Tang
  • Yu Xue
  • Wuhan Xiao
  • Jing Xia Liu
  • Wolfgang Driever
  • Manuel Leichsenring
  • Karen Lunde
  • Bo Hu
  • Daria Onichtchouk
  • Björn Wendik
  • Rebecca Mössner
  • Fredericus J M van Eeden
  • Robert A Cornell
  • Stephen W Wilson
  • Elly M Sweet
  • Mikiko Tanaka

Detail Information

Publications49

  1. pmc Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:3581-92. 2004
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue...
  2. ncbi FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation
    Iban Seiliez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France
    Dev Biol 290:152-63. 2006
    ..Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a...
  3. ncbi Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
    Shun Kuo Sun
    Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 303:675-86. 2007
    ..However, the forkhead factor, Foxi1, is required for both otic and epibranchial placode development...
  4. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
    ..In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest-acting genes in this process...
  5. pmc Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 238:1582-94. 2009
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc...
  6. ncbi Zebrafish foxi1 mediates otic placode formation and jaw development
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 130:929-40. 2003
    ..Here, we identify a mutation in zebrafish, hearsay, which disrupts the initiation of placode formation...
  7. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all ..
  8. ncbi Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 294:376-90. 2006
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border...
  9. pmc The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure
    Jizhou Yan
    National Human Genome Research Institute, Genome Technology Branch, NIH, Bldg 50, Rm 5537, 50 South Dr, Bethesda, MD 20892, USA
    Mol Cell Biol 26:155-68. 2006
    ..We created a stable cell line expressing FoxI1-green fluorescent protein (GFP) or FoxI1-V5 fusion proteins under control of the reverse tetracycline-controlled ..
  10. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
    ..further provide evidence that pax8 expression and pax2a expression are regulated by two independent factors, Foxi1 and Dlx3b, respectively. Combined loss of both factors eliminates all indications of otic specification...
  11. pmc Mechanism of development of ionocytes rich in vacuolar-type H(+)-ATPase in the skin of zebrafish larvae
    Masahiro Esaki
    Department of Biological Sciences, Tokyo Institute of Technology, Midori ku, Yokohama, Japan
    Dev Biol 329:116-29. 2009
    ..In the present study, we analyzed a zebrafish mutant, quadro (quo), deficient in foxi1 gene expression and found that foxi1 is essential for development of an MRC ..
  12. ncbi Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling
    Muriel Rhinn
    Department of Genetics, University of Technology Dresden, c o Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Development 132:1261-72. 2005
    ..Our findings argue that graded Wnt8 activity mediates overall neuroectodermal posteriorization and thus determines the location of the MHB organizer...
  13. ncbi Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning
    Robert M Nissen
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 130:2543-54. 2003
    ..We identified foxi one (foo), the zebrafish ortholog of Foxi1 (FREAC6, FKHL10, HFH-3, Fkh10) and a member of the forkhead domain transcriptional regulator family, as the gene ..
  14. pmc Zebrafish as an animal model to study ion homeostasis
    Pung Pung Hwang
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan
    Pflugers Arch 465:1233-47. 2013
    ....
  15. doi Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage
    Stefan Hans
    Technische Universitat Dresden, Biotechnology Center and DFG Center for Regenerative Therapies Dresden Cluster of Excellence, Tatzberg 47 49, Dresden, Germany
    Development 140:1936-45. 2013
    ..In zebrafish, the otic-epibranchial progenitor domain (OEPD) is induced by Fgf signaling in a Foxi1- and Dlx3b/4b-dependent manner, but the functional differences of Foxi1 and Dlx3b/4b in subsequent cell fate ..
  16. doi Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression
    Heinz Georg Belting
    Developmental Biology, Faculty of Biology, University of Freiburg, Hauptstrasse 1, Freiburg, Germany
    Dev Biol 356:323-36. 2011
    ..Our data reveals a set of direct and indirect interactions of Pou5f1 with the BMP dorsoventral patterning network that serve to fine-tune dorsoventral patterning mechanisms and coordinate patterning with developmental timing...
  17. doi Conditions that influence the response to Fgf during otic placode induction
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 364:1-10. 2012
    ..Elevated Fgf also expands expression of the putative competence factor Foxi1, which is required for Fgf to expand other otic markers...
  18. pmc A gene network that coordinates preplacodal competence and neural crest specification in zebrafish
    Neha Bhat
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 373:107-17. 2013
    ..Elevated Bmp establishes preplacodal competence throughout the ventral ectoderm by coinducing Tfap2a, Tfap2c, Foxi1 and Gata3...
  19. doi Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos
    Shunji Jia
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Dev Cell 22:1065-78. 2012
    ..We conclude that Ppp4c is a critical positive regulator of BMP/Smad signaling during embryonic dorsoventral pattern formation in zebrafish...
  20. pmc Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw
    Xuelong Wang
    Institute for Marine Biosystems and Neurosciences, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai, China
    PLoS ONE 7:e45380. 2012
    ..These cells are transformed into two populations of blastemal progenitors: foxi1-expression and isl1-expression, before giving rise to cartilage, bone, and muscle...
  21. pmc Identification of the zebrafish maternal and paternal transcriptomes
    Steven A Harvey
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Development 140:2703-10. 2013
    ....
  22. pmc Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos
    Carlos Cruz
    School of Biosciences, University of Exeter, Devon EX4 4SP, UK
    Proc Natl Acad Sci U S A 107:3564-9. 2010
    ..We conclude that eve1 is crucial for the organization of the antero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting activity...
  23. pmc Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants
    Elizabeth E LeClair
    Department of Biological Sciences, DePaul University, Chicago, Illinois 60614, USA
    Dev Dyn 238:2550-63. 2009
    ..In contrast, gpc4(-/-) larvae never form these domains, suggesting a failure of chondrocyte orientation, though not differentiation. Our findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis...
  24. pmc Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle
    Katherine L Hammond
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Development 137:1361-71. 2010
    ....
  25. pmc Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis
    Michael J F Barresi
    Biological Sciences, Smith College, Northampton, Massachusetts 01063, USA
    Dev Dyn 239:2603-18. 2010
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS...
  26. pmc Identification of early requirements for preplacodal ectoderm and sensory organ development
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 6:e1001133. 2010
    ..Initially, Bmp is required before gastrulation to co-induce four transcription factors, Tfap2a, Tfap2c, Foxi1, and Gata3, which establish preplacodal competence throughout the nonneural ectoderm...
  27. pmc Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 351:90-8. 2011
    ..In zebrafish, both are initiated by localized Fgf signaling plus the ubiquitous competence factor Foxi1, and both express pax8 and sox3 in response...
  28. pmc Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis
    Xun Wei Xie
    Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    PLoS ONE 6:e24469. 2011
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis...
  29. pmc Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output
    Sunit Dutta
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3013-8. 2010
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  30. ncbi Mutations affecting development of the zebrafish ear
    J Malicki
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:275-83. 1996
    ..Embryos mutant at the quadro locus display abnormal specification of the otic placode...
  31. pmc Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva
    Leila Abbas
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Development 136:2837-48. 2009
    ..This exemplifies the use of morpholinos as potential therapeutic agents for genetic disease...
  32. pmc Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish
    Sarah Kucenas
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO, 63104, USA
    Purinergic Signal 5:395-407. 2009
    ..These data suggest that p2rx3.1 function in ectodermal cells is involved in purinergic signaling essential for proper craniofacial development and sensory circuit formation in the embryonic and larval zebrafish...
  33. ncbi Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity
    Sophie Dal-Pra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, CNRS INSERM ULP, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
    Dev Biol 298:514-26. 2006
    ....
  34. ncbi Expression and phylogenetic analyses of three zebrafish FoxI class genes
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 228:301-7. 2003
    ..We have reported previously the identification of zebrafish foxi1, which is required for otic placode and jaw development...
  35. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies...
  36. ncbi Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
    Melinda D Mackereth
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 132:371-82. 2005
    ..In contrast, the phenotype caused by disrupting foxi1, which is required for pax8 expression, was not enhanced by simultaneously disrupting pax8...
  37. ncbi Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 132:3717-30. 2005
    ..Surprisingly, ectodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endoderm-deficient embryos and ..
  38. ncbi Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish
    Jochen Holzschuh
    Department of Developmental and Cell Biology, University of California, 5438 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3731-42. 2005
    ..Our results show that the endoderm regulates the differentiation of cranial sensory ganglia, which coordinates the cranial nerves with the segments that they innervate...
  39. ncbi The genetics of hearing and balance in zebrafish
    Teresa Nicolson
    Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Annu Rev Genet 39:9-22. 2005
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish...
  40. ncbi Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling
    Morgane Poulain
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Development 133:2189-200. 2006
    ..These results identify a molecular mechanism whereby FGF attenuates Nodal-induced endodermal transcription factors and highlight a potential mechanism whereby mesoderm and endoderm fates could segregate from each other...
  41. ncbi A change in response to Bmp signalling precedes ectodermal fate choice
    Chris T Dee
    Institute of Genetics, University of Nottingham, QMC, Nottingham, UK
    Int J Dev Biol 51:79-84. 2007
    ..Hence, we have shown a dynamic change in the molecular machinery underlying the Bmp response in the ectoderm during gastrulation stages of development...
  42. ncbi Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..Here, we show that zebrafish embryos mutant for fgf3 and fgf8 do not express early EB placode markers, including foxi1 and pax2a...
  43. ncbi Changes in retinoic acid signaling alter otic patterning
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 134:2449-58. 2007
    ..Excess RA leads to ectopic foxi1 expression throughout the entire preplacodal domain. Foxi1 provides competence to adopt an otic fate...
  44. pmc Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
    Sergey Yaklichkin
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1110 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    BMC Genomics 8:201. 2007
    ..Defining conserved functional domains that mediate the transcriptional activity of Fox proteins will contribute to a comprehensive understanding of the biological function of Fox family genes...
  45. ncbi Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Development 134:2871-9. 2007
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects...
  46. pmc Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo
    Máté Varga
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mech Dev 124:775-91. 2007
    ....
  47. pmc Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins
    Jue Zeng
    Division of Hematology Oncology, Department of Medicine, University of California, Irvine, CA, USA
    Nucleic Acids Res 36:e8. 2008
    ..The experimental approach was validated with the tumor suppressor protein p53 and the forkhead protein FoxI1 using genomic libraries for zebrafish and mouse generated by shotgun cloning of short genomic fragments...
  48. pmc A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle
    Kirsten Dutton
    Department of Biology and Biochemistry, Centre for Regenerative Medicine, Developmental Biology Programme, University of Bath, Bath, UK
    Dis Model Mech 2:68-83. 2009
    ..We discuss the implication that the deafness in WS4 patients with SOX10 mutations might reflect a haploinsufficiency for SOX10 in the otic epithelium, resulting in patterning and functional abnormalities in the inner ear...
  49. ncbi Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons
    S Guo
    Department of Neuroscience, Genentech, Inc, 1 DNA Way, South San Francisco, California, 94080, USA
    Dev Biol 208:473-87. 1999
    ..The too few mutation leads to a specific reduction in the number of hypothalamic DA neurons. no soul lacks arch-associated NA cells and has defects in pharyngeal arches, and soulless lacks both arch-associated and ..

Research Grants7

  1. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
    ..This research will lead to a better understanding of events critical to establishing neural connections across the midline in the vertebrate brain. ..
  2. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009
    ..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..