Gene Symbol: foxc1b
Description: forkhead box C1b
Alias: foxc1.2, id:ibd5079, forkhead box C1-B
Species: zebrafish
Products:     foxc1b

Top Publications

  1. Skarie J, Link B. FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. Invest Ophthalmol Vis Sci. 2009;50:5026-34 pubmed publisher
    ..Genetic interactions between FOXC1 and basement membrane components influence vascular stability and may impact glaucoma development and increase stroke risk in FOXC1 patients. ..
  2. Acharya M, Huang L, Fleisch V, Allison W, Walter M. A complex regulatory network of transcription factors critical for ocular development and disease. Hum Mol Genet. 2011;20:1610-24 pubmed publisher
    ..We have therefore identified a functional link between three transcription factors, modulated by PAWR, which we propose underlies the similar ocular phenotypes and glaucoma pathology caused by mutations of these genes. ..
  3. Miesfeld J, Link B. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. Mech Dev. 2014;133:177-88 pubmed publisher
    ..These studies highlight the utility of this transgenic tool-suite for ongoing analysis into the mechanisms of Hippo pathway regulation and the consequences of signaling output. ..
  4. Kim A, Melick C, Clements W, Stachura D, Distel M, Panáková D, et al. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014;33:2363-73 pubmed publisher
  5. Miesfeld J, Gestri G, Clark B, Flinn M, Poole R, Bader J, et al. Yap and Taz regulate retinal pigment epithelial cell fate. Development. 2015;142:3021-32 pubmed publisher
  6. Qiu J, Fan X, Wang Y, Jin H, Song Y, Han Y, et al. Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. J Mol Cell Biol. 2016;8:288-301 pubmed publisher
    ..Therefore, the embryonic origin of dHSCs in adults is not restricted to the AGM. ..
  7. Chen X, Gays D, Milia C, Santoro M. Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Rep. 2017;18:1033-1047 pubmed publisher
    ..We also identify zebrafish foxc1b as a cilia-dependent Notch-specific target that is required within endothelial cells to drive vMC recruitment...
  8. Tamimi Y, Skarie J, Footz T, Berry F, Link B, Walter M. FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Hum Mol Genet. 2006;15:3229-40 pubmed
    ..This study reveals an important role for FOXC1 in the direct regulation of the FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. ..
  9. Veldman M, Lin S. Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast. Circ Res. 2012;110:220-9 pubmed publisher
    ..3 kb upstream of etsrp contains a consensus FOX binding site that binds Foxc1a and Foxc1b in vitro by EMSA and in vivo using ChIP...

More Information


  1. French C, Seshadri S, Destefano A, Fornage M, Arnold C, Gage P, et al. Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J Clin Invest. 2014;124:4877-81 pubmed publisher
    ..Together, these results extend the genetic etiology of stroke and demonstrate an increasing developmental basis for human cerebrovascular disease. ..
  2. Topczewska J, Topczewski J, Solnica Krezel L, Hogan B. Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mech Dev. 2001;100:343-7 pubmed
    ..Here, we report the cloning and expression of two zebrafish foxc1 homologues, foxc1a and foxc1b. During gastrulation and somitogenesis both genes have similar expression patterns in the hypoblast, paraxial and ..
  3. McMahon C, Semina E, Link B. Using zebrafish to study the complex genetics of glaucoma. Comp Biochem Physiol C Toxicol Pharmacol. 2004;138:343-50 pubmed
    ..With zebrafish, forward and reverse genetic approaches can be combined in order to identify critical genetic interactions required for normal and pathological events in the development and maintenance of the eye. ..
  4. Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
  5. De Val S, Chi N, Meadows S, Minovitsky S, Anderson J, Harris I, et al. Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell. 2008;135:1053-64 pubmed publisher
    ..Finally, we show that FOX:ETS motifs are present in many known endothelial-specific enhancers and that this motif is an efficient predictor of endothelial enhancers in the human genome. ..
  6. Eason J, Williams A, Chawla B, Apsey C, Bohnsack B. Differences in neural crest sensitivity to ethanol account for the infrequency of anterior segment defects in the eye compared with craniofacial anomalies in a zebrafish model of fetal alcohol syndrome. Birth Defects Res. 2017;109:1212-1227 pubmed publisher
    ..These studies explain the rarity of anterior segment dysgenesis despite the frequent craniofacial abnormalities in fetal alcohol syndrome. Birth Defects Research 109:1212-1227, 2017. © 2017 Wiley Periodicals, Inc. ..