foxb1a

Summary

Gene Symbol: foxb1a
Description: forkhead box B1a
Alias: cb114, fkd3, foxb1.2, mar, forkhead box protein B1, fork head domain protein 3, forkhead box B1.2, forkhead-3, mariposa
Species: zebrafish
Products:     foxb1a

Top Publications

  1. Cooke J, Kemp H, Moens C. EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish. Curr Biol. 2005;15:536-42 pubmed
  2. Amoyel M, Cheng Y, Jiang Y, Wilkinson D. Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development. 2005;132:775-85 pubmed
    ..The network of genes underlying the regulation of neurogenesis and lateral inhibition of boundary cell formation by Wnt1 has a striking similarity to mechanisms at the dorsoventral boundary in the Drosophila wing imaginal disc. ..
  3. Qiu X, Lim C, Ho S, Lee K, Jiang Y. Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries. Dev Genes Evol. 2009;219:339-51 pubmed publisher
  4. Moens C, Yan Y, Appel B, Force A, Kimmel C. valentino: a zebrafish gene required for normal hindbrain segmentation. Development. 1996;122:3981-90 pubmed
    ..These results provide genetic evidence for a two-segment periodicity in the hindbrain and suggest that this periodicity arises sequentially, through the specification and later subdivision of a two-rhombomere unit, or 'protosegment'. ..
  5. Nguyen V, Schmid B, Trout J, Connors S, Ekker M, Mullins M. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev Biol. 1998;199:93-110 pubmed
    ..Based on the alterations in tissue-specific gene expression, we propose a model whereby swirl/bmp2b acts as a morphogen to specify different cell types along the dorsoventral axis. ..
  6. Odenthal J, Nusslein Volhard C. fork head domain genes in zebrafish. Dev Genes Evol. 1998;208:245-58 pubmed
    ..Transcripts of fkd3 and fkd5 (class II) are mainly detected in the cells of the ectoderm which form neural tissues, as is the case for ..
  7. Varga Z, Wegner J, Westerfield M. Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops. Development. 1999;126:5533-46 pubmed
    ..cells contributed to both retinas, bordered posteriorly by diencephalic precursors expressing mariposa. Median mariposa-expressing cells moved anteriorly, separating the eyes, and formed ventral anterior diencephalon,..
  8. McClintock J, Carlson R, Mann D, Prince V. Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. Development. 2001;128:2471-84 pubmed
    ..We also find that an intriguing function 'shuffling' between paralogues has occurred, such that one of the zebrafish hoxb1 duplicates, hoxb1b, performs the role in hindbrain patterning played in mouse by the non-orthologous Hoxa1 gene. ..
  9. Cooke J, Moens C. Boundary formation in the hindbrain: Eph only it were simple. Trends Neurosci. 2002;25:260-7 pubmed
    ..We discuss the contributions of two mechanisms -- cell sorting and plasticity -- to the formation of rhombomere boundaries. ..

More Information

Publications48

  1. Cheng Y, Amoyel M, Qiu X, Jiang Y, Xu Q, Wilkinson D. Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Dev Cell. 2004;6:539-50 pubmed
    ..These findings reveal that Notch activation couples the regulation of location and differentiation in hindbrain boundary cells. Such coupling may be important for these cells to act as a stable signaling center. ..
  2. Mullins M, Hammerschmidt M, Kane D, Odenthal J, Brand M, van Eeden F, et al. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development. 1996;123:81-93 pubmed
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield. ..
  3. Tucker J, Mintzer K, Mullins M. The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev Cell. 2008;14:108-19 pubmed publisher
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously. ..
  4. Riley B, Chiang M, Storch E, Heck R, Buckles G, Lekven A. Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev Dyn. 2004;231:278-91 pubmed
    ..Similar feedback mechanisms operate in the Drosophila wing disc and vertebrate limb bud, suggesting coaptation of a conserved signaling module that spatially organizes cells in complex organ systems. ..
  5. Kaestner K, Knochel W, Martinez D. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 2000;14:142-6 pubmed
  6. Hammerschmidt M, Serbedzija G, McMahon A. Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev. 1996;10:2452-61 pubmed
    ..Together, these results provide genetic evidence in support of a mechanism of early dorsoventral patterning that is conserved among vertebrate and invertebrate embryos. ..
  7. Qiu X, Xu H, Haddon C, Lewis J, Jiang Y. Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe. Dev Dyn. 2004;231:621-30 pubmed
  8. Little S, Mullins M. Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development. 2004;131:5825-35 pubmed
    ..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning. ..
  9. Putiri E, Pelegri F. The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes. Dev Biol. 2011;353:275-89 pubmed publisher
    ..Maternal RNA helicases have long been known to be involved in the development of the animal germ line, but our findings add to growing evidence that these factors may also control specific gene expression programs in somatic tissues. ..
  10. Hong S, Dawid I. The transcriptional mediator component Med12 is required for hindbrain boundary formation. PLoS ONE. 2011;6:e19076 pubmed publisher
    ..The kto/med12 mutation results in specific defects of boundary cell formation in the zebrafish hindbrain. ..
  11. Kramer C, Mayr T, Nowak M, Schumacher J, Runke G, Bauer H, et al. Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev Biol. 2002;250:263-79 pubmed
    ..This indicates that maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry. ..
  12. Miyares R, Stein C, Renisch B, Anderson J, Hammerschmidt M, Farber S. Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo. Dev Cell. 2013;27:635-47 pubmed publisher
    ..Our results reveal a critical role for Acsl4a in modulating Bmp-Smad activity and provide a potential avenue for LC-PUFAs to influence a variety of developmental processes. ..
  13. Kapsimali M, Caneparo L, Houart C, Wilson S. Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development. 2004;131:5923-33 pubmed
  14. Wong L, Weadick C, Kuo C, Chang B, Tropepe V. Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Dev Biol. 2010;10:100 pubmed publisher
  15. Hammerschmidt M, Pelegri F, Mullins M, Kane D, van Eeden F, Granato M, et al. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 1996;123:95-102 pubmed
    ..Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo. ..
  16. Leskow F, Holloway B, Wang H, Mullins M, Kazanietz M. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006;103:5373-8 pubmed
    ..Our results reveal a crucial role for chn1 in early development and implicate Rac as a key regulator of morphogenetic movements during zebrafish epiboly. ..
  17. Varga M, Maegawa S, Weinberg E. Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Dev Biol. 2011;11:26 pubmed publisher
    ..We also show that the zebrafish embryo can form a radial diffuse neural sheath in the absence of both BMP signaling and the early organizer. ..
  18. Holloway B, Gomez de la Torre Canny S, Ye Y, Slusarski D, Freisinger C, Dosch R, et al. A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet. 2009;5:e1000413 pubmed publisher
    ..We postulate that a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses. ..
  19. Skromne I, Thorsen D, Hale M, Prince V, Ho R. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development. 2007;134:2147-58 pubmed
    ..We propose that by preventing the posterior-most region of the neural plate from following a hindbrain developmental program, Cdx factors help determine the size of the prospective hindbrain and spinal cord territories. ..
  20. Dutta S, Dietrich J, Aspöck G, Burdine R, Schier A, Westerfield M, et al. pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 2005;132:1579-90 pubmed
    ..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types. ..
  21. Yang J, Zeng Z, Wei J, Jiang L, Ma Q, Wu M, et al. Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish. Biochem Biophys Res Commun. 2013;433:213-9 pubmed publisher
    ..Collectively, these data suggest that sema4d plays an important role in the development of the hindbrain and skeletal muscle. ..
  22. Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
  23. Yan Y, Jowett T, Postlethwait J. Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos. Dev Dyn. 1998;213:370-85 pubmed
    ..The results suggest that hoxb2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish. ..
  24. Shen Q, Little S, Xu M, Haupt J, Ast C, Katagiri T, et al. The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest. 2009;119:3462-72 pubmed publisher
  25. Jurynec M, Grunwald D. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Dis Model Mech. 2010;3:733-42 pubmed publisher
    ..We suggest that modulation of FGF signaling may be a principal function of SHIP2 in mammals. ..
  26. Cavodeassi F, Carreira Barbosa F, Young R, Concha M, Allende M, Houart C, et al. Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron. 2005;47:43-56 pubmed
  27. Montero J, Carvalho L, Wilsch Bräuninger M, Kilian B, Mustafa C, Heisenberg C. Shield formation at the onset of zebrafish gastrulation. Development. 2005;132:1187-98 pubmed
  28. Förster D, Arnold Ammer I, Laurell E, Barker A, Fernandes A, Finger Baier K, et al. Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Sci Rep. 2017;7:5230 pubmed publisher
    ..Taken together, our study offers new tools for functional studies of specific neural circuits in zebrafish. ..
  29. Nakada C, Satoh S, Tabata Y, Arai K, Watanabe S. Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish. Mol Cell Biol. 2006;26:7246-57 pubmed
    ..In view of all of our data taken together, we propose zfoxl1 to be a novel regulator of neural development that acts by suppressing shh expression. ..
  30. Waskiewicz A, Rikhof H, Moens C. Eliminating zebrafish pbx proteins reveals a hindbrain ground state. Dev Cell. 2002;3:723-33 pubmed
  31. Wolf A, Ryu S. Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development. 2013;140:1762-73 pubmed publisher
  32. McFarland K, Warga R, Kane D. Genetic locus half baked is necessary for morphogenesis of the ectoderm. Dev Dyn. 2005;233:390-406 pubmed
  33. Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, et al. Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. J Cell Sci. 2012;125:1129-40 pubmed publisher
    ..This study identifies the importance of the syntenin-syndecan-PIP2-Arf6 complex for the progression of fish epiboly and establishes its key role in directional cell movements during early development. ..
  34. Staudt N, Houart C. The prethalamus is established during gastrulation and influences diencephalic regionalization. PLoS Biol. 2007;5:e69 pubmed
    ..This cell-non-autonomous property led us to propose that these committed prethalamic precursors may play an instructive role in the regionalization of the developing diencephalon. ..
  35. Little S, Mullins M. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol. 2009;11:637-43 pubmed publisher
  36. Ghiselli G, Farber S. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol. 2005;5:19 pubmed
    ..In particular Glce acts during gastrulation by affecting Bmp-mediated cell specification. The results obtained further corroborate the concept that HS encodes information that affect morphogenesis during early vertebrate development. ..
  37. Van de Peer Y, Frickey T, Taylor J, Meyer A. Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 2002;295:205-11 pubmed
    ..When trees are computed by omitting the saturated fraction of sites, most fish duplicates are sister sequences. ..
  38. Warga R, Kane D. One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling. Dev Biol. 2003;261:391-411 pubmed
    ..We conclude that, in addition to a role in Nodal signaling, One-eyed pinhead is required for aspects of cell movement, possibly by regulating cell adhesion. ..
  39. Formstone C, Mason I. Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev Biol. 2005;282:320-35 pubmed
    ..However, while we show that control over axial extension is autonomous, we find that Fmi1a is not required within lateral cells undergoing dorsal convergence. ..